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Biography

Prof. Stephen C. Strom

Department of Laboratory Medicine

Karolinska Institutet, Sweden

Professor


Email: strom@pitt.edu


Qualifications

1978 Ph.D, University of Kansas Medical Center, Pharmacology

1974 B.A., Westmar College, Biol. & Chemistry


Publications (selected)

  1. Gross-Steinmeyer K, Stapleton PL, Tracy JH, Bammler TK, Strom SC, Eaton DL. (2010) Sulforaphane- and phenethyl isothiocyanate-induced inhibition of aflatoxin B1-mediated genotoxicity in human hepatocytes: role of GSTM1 genotype and CYP3A4 gene expression. Toxicol Sci 116: 422-32.
  2. Yang X, Zhang B, Molony C, Chudin E, Hao K, Zhu J, Gaedigk A, Suver C, Zhong H, Leeder JS, Guengerich FP, Strom SC, Schuetz E, Rushmore TH, Ulrich RG, Slatter JG, Schadt EE, Kasarskis A, Lum PY. (2010) Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver. Genome Res 20: 1020-36.
  3. Kamagate, AKim, DH Zhang, T, Sluser, S, Gramignoli, R, Bertera, S, Ringquist, S, Dong, HH (2010) FOXO1 links hepatic insulin action to endoplasmic reticulum stress. Endocrinology 151: 3521-3535.
  4. Sharma, S Venkataramanan, R, Caritis, S, Dorko, K, Strom, SC. (2010) Metabolism of 17α-hydroxyprogesterone caproate by fetal liver: A new agent for preventing pre-term labor. Drug Metabolism and Disposition: the biological fate of chemicals 38(5): 723-727.
  5. Shufeng Liu, Wayne Kuo, Wei Yang, Gregory A. Gibson, Kenneth Dorko, Simon C. Watkins, Stephen C. Strom, Tianyi Wang. (2010) The second extracellular loop dictates Occludin-mediates HCV entry. Virology 407(1): 160-170.
  6. Strom SC, Davila J, Grompe M. 2010. Chimeric mice with humanized liver: tools for the study of drug metabolism, excretion, and toxicity. Methods Mol Biol 640: 491-509.
  7. Soltys KA, Soto-Gutierrez A, Nagaya M, Baskin KM, Deutsch M, Ito R, Shneider BL, Squires R, Vockley J, Guha C, Roy-Chowdhury J, Strom SC, Platt JL, Fox IJ. (2010). Barriers to the successful treatment of liver disease by hepatocyte transplantation. J Hepatol 53: 769-74.
  8. Kim, DH, Perdomo, G, Zang, T, Slusher, S, Lee, S, Phillips, YF, Giannoukakis, N, Gramignoli, R., Strom, S, Rinquist, S, Dong, HH. Fox06 integrates insulin signaling with gluconeogenesis in the liver. Diabetes 60: 2763-2774.
  9. Singh, R, Bullard, J, Kalra, M, Assefa, S, Kaul, AK, Vonfeldt, K, Strom, SC, Conrad, RS, Sharp, HL, Kaul, R. (2011) Status of bacterial colonization, toll-like receptor expression and nuclear factor-kappaB activation in normal and diseased human livers. Clin. Immunol. 138: 41-40.
  10. Ou, Zhimin, Wada, T, Gramignoli, R, Li, S, Strom, SC, Huang, M, Xie, W. (2011) MicroRNA has-mir-613 targets the human LXRalpha gene and mediates a feedback loop of LXR autoregulation. Mol. Endocrinol. 25(4): 584-596.
  11. Soto-Gutierrez, A, Zhang, L, Medberry, C, Fukumitsu, K, Faulk, D, Jiang, H, Reing, J, Gramignoli, R, Komori, J, Ross, M, Herrera, B, Nagaya, M, Lagasse, E, Stolz, D, Strom, SC, Fox, IJ, Badylak, S. (2011) A whole organ regenerative medicine approach for liver replacement. Tissue Engineering, Part C Methods.17: 677-686.
  12. Marongiu, F Gramignoli, R, Dorko, K, Miki, T, Sharma, S, Tahan, V, Skvorak, KJ, Ellis, E, Davila, J, Laconi, E, Strom, SC (2011) Hepatic differentiation of human amnion epithelial cells. Hepatology 53: 1719-1725.
  13. Meyer zu Schwabedissen, HE, Ware, JA, Finkelstein, D., Chaudhry, AS, Mansell, S, Leon-Ponte, M, Strom, SC, Zaher, H, Schwartz, UI, Freeman, DJ, Schuetz, EG, Triona, RG, Kim, RB. (2011) Hepatic organic anion transporting polypeptide transporter and thyroid hormone receptor interplay determine cholesterol and glucose hemostasis. Hepatology 54: 644-654.
  14. Duncan, AW, Hanlon-Newell, AE, Smith, L, Wilson, EM, Olson, SB, Thayer, MJ, Strom, SC, Grompe, M. (2012) Frequent aneuploidy among normal human hepatocytes. Gastroenterology (2012) 142: 25-28.
  15. Gramignoli, R, Green, M, Tahan, V. Dorko, K, Skvorak, K, Marongiu, F, Zao, W, Venkataramanan, R, Ellis, ECS, Geller, D, Breite, A, Dwulet, F, McCarthy, R, Strom, SC. Development and application of purified tissue dissociation enzyme mixtures for human hepatocyte isolation, Cell Transplantation (2012) 21: 1245-1260.
  16. Puppi, J, Strom, SC, Hughes, RD, Bansal, S, Castell, JV, Dagher, I, Ellis, EC, Nowak, G., Ericzon, B-G , Fox, IJ, Gómez-Lechón, MJ, Guha, C, Gupta, S, Mitry R, Ohashi, K Ott, M, Reid, M, Roy-Chowdhury, J, Sokal, E, Weber, A Dhawan, A. (2011) Improving the Techniques for Human Hepatocyte Transplantation: Report from a Consensus Meeting in London . Cell Transplantation 21: 1-10.
  17. Jorns, C, Ellis, EC, Nowak, G, Fischler, B, Nemeth, A, Strom, SC, Ericzon, BG (2012) Hepatocyte transplantation for inherited metabolic diseases of the liver. J. Internal Medicine 272: 201-223
  18. Metukuri, MR, Zhang, P, Basantani, MK, Chin, C., Stamateters, RE, Alonso, LC, Takane, K, Gramignoli, R, Strom, SC, O’Doherty, RM, Stewart, AF, Vasavada, RC, Garcia-Ocana, A, Scott, DK. ChREBP mediates glucose-stimulated pancreatic beta cell proliferation. Diabetes 61: 2004-2015.
  19. Noreault-Conti, TL, Fellows, A, Jacobs, J, Trask, H, Strom, SC, Evans, RA, Wrighton, S, Sinclair, P, Sinclair, J, Nichols. R. (2012) Arsenic decreases RXR±-dependent transcription of CYP3A and suppresses immune regulators in hepatocytes. Intl. Immunopharmacology 4: 651-656.
  20. Zang, S, Pillai, VC, Mada, SR, Strom, S, Venkataramanan, R. (2012) Effects of voriconazole and other azole antifungal agents on CYP3A activity and metabolism of tacrolimus in human liver microsomes. Xenobiotica 42: 409-416.
  21. Skvorak, K, Dorko, K, Marongiu, F, Tahan, V, Hansel, MC, Gramignoli, R, Gibson, KM, Strom, SC. (2012) Placental stem cell correction of murine intermediate maple syrup urine disease. Hepatology.
  22. Hansel, MC, Gramignoli, R, Blake, W, Davila, J, Skvorak, KJ, Dorko, K, Tahan, V, Brian R. Lee, B, Tafaleng E, Guzman-Lepe, JG, Soto-Gutierrez, A, Fox, IJ, Strom, SC. Increased reprogramming of human fetal hepatocytes compared to adult hepatocytes under feeder-free conditions. Cell Transplantation (In Press).
  23. Ou, Z, Shi, X, Gilroy, RK, Kirisci, L, Romkes, M, Lynch, C, Wang, H, Xu, M, Jiang, M, Ren, S, Gramignoli, R, Strom, SC, Huang, M, Xie, W. (2012) Regulation of human hydroxysteroid sulfotransferase SUL2A1 by ROR-alpha and ROR-gamma and its potential relevance in human liver diseases. Molecular Endocrinology (In press).
  24. Sharma, S, Ellis, EC, Venkataramanan, R, Cretis, S, Dorko, K, Strom, SC. Hepatobiliary disposition of 17-OHPC and taurocholate in fetal human hepatocytes: a comparison with adult human hepatocytes. Drug Metabolism and Disposition (2012) epub, 5 November 2012.

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