Dr. Liqin Zhao

Department of Pharmacology & Toxicology

School of Pharmacy, University of Kansas, USA

Assistant Professor



2002-2013 Research Assistant Professor, Research Associate Professor, University of Southern California, Neuroscience

1999-2002 Postdoctoral Fellow, Beijing Institute of Pharmacology & Toxicology, Neuroscience

1989-1999 B.S., M.S., Ph.D., Shenyang Pharmaceutical University, Pharmaceutical Sciences

Publications (selected)

  1. Zhao, L., Wu,T-W. and Brinton, R.D. (2004)Estrogen Receptor Subtypes Alpha and Beta Contribute to Neuroprotection and Increased Bcl-2 Expression in Primary Hippocampal neurons. Brain Res 1010(1-2):22-34. PMID: 15126114.
  2. Zhao, L., O’Neill, K. and Brinton, R.D. (2005) Selective Estrogen Receptor Modulators (SERMs) for the Brain: Current Status and Remaining Challenges for Developing NeuroSERMs. Brain Res Rev 49(3):472-493. PMID: 16269315.
  3. Zhao, L. and Brinton, R.D. (2005) Structure-Based Virtual Screening for Plant-Based ER-selective Ligands as Potential Preventative Therapies Against Age-Related Neurodegenerative Diseases. J Med Chem 48(10):3463-3466. PMID: 15887952.
  4. Zhao, L. and Brinton, R.D. (2006) Select Estrogens within the Complex Formulation of Conjugated Equine Estrogens (Premarin) Are Protective Against Neurodegenerative Insults: Implications for a Composition of Estrogen Therapy to Promote Neuronal Function and Prevent Alzheimer’s Disease. BMC Neurosci 7:24(1-13). PMID: 16533397.
  5. Zhao, L., Liu, H., Hu, Y., Wang, L. and Li, S. (2006) Modeling and Synthesis of Non-Cyclic Derivatives of GPI-1046 as Potential FKBP12 Ligands with Neurotrophic Properties. Bioorg Med Chem Lett 16(16):4385-4390, 2006. PMID: 16753298.
  6. Zhao, L., Huang, W., Liu, H., Wang, L., Hu, Y., Xiao, J. and Li, S. (2006) FK506-Binding Protein Ligands: Structure-Based Design, Synthesis, and Neurotrophic/Neuroprotective Properties of Substituted 5,5-Dimethyl-2-(4-thiazolidine)carboxylates. J Med Chem 49(14): 4059-4071. PMID: 16821768.
  7. Zhao, L. and Brinton, R.D. (2006) Estrogen Receptor as a Therapeutic Target for Promotion of Neurogenesis and Prevention of Neurodegeneration. Drug Dev Res 66(2):103-117.
  8. Zhao, L., O’Neill, K. and Brinton, R.D. (2006) Estrogenic Agonist Activity of ICI 182,780 in Hippocampal Neurons: Implications for Basic Science Understanding of Estrogen Signaling and Development of Estrogen Modulators with a Dual Therapeutic Profile. J Pharmacol Exp Ther 319(3):1124-1132. PMID: 16951259.
  9. Zhao, L., Jin C., Mao, Z., Gopinathan, M.B., Rehder, K. and Brinton, R.D. (2007) Design, Synthesis, and Estrogenic Activity of a Novel Estrogen Receptor Modulator - A Hybrid Structure of 17-Estradiol and Vitamin E in Hippocampal Neurons. J Med Chem 50(18):4471-4481. PMID: 17696335.
  10. Zhao, L. and Brinton, R.D. (2007) Estrogen Receptor and Differentially Regulate Intracellular Ca2+ Dynamics Leading to ERK Phosphorylation and Estrogen Neuroprotection in Hippocampal Neurons. Brain Res 1172:48-59. PMID: 17803971.
  11. Zhao, L. and Brinton, R.D. (2007) WHI and WHIMS Follow-Up and Human Studies of Soy Isoflavones on Cognition. Expert Rev Neurotherapeutics 7(11):1549-1564. PMID: 17997703.
  12. Yao, J., Irwin, R., Zhao, L., Nilsen, J., Hamilton, R. and Brinton, R.D. (2009) Mitochondrial Bioenergetic Deficit Precedes Alzheimer’s Pathology in Female Mouse Model of Alzheimer’s Disease. PNAS 106(34):14670-14675. PMID: 19667196.
  13. Zhao, L., Mao, Z. and Brinton, R.D. (2009) A Select Combination of Clinically Relevant Phytoestrogens Enhances Estrogen Receptor-Binding Selectivity and Neuroprotective Activities In Vitro and In Vivo. Endocrinology 150(2):770-783. PMID: 18818291.
  14. Liu, L., Wang, J., Zhao, L., Nilsen, J., McClure, K., Wong, K. and Brinton, R.D. (2009) Progesterone Increases Rat Neural Progenitor Cell Cycle Gene Expression and Proliferation via Extracellularly Regulated Kinase and Progesterone Receptor Membrane Components 1 and 2. Endocrinology 150(7):3186-3196. PMID: 19359388.
  15. Liu, L., Zhao, L., She, H., Chen, S., Wang, J., Wong, C., McClure, K., Sitruk-Ware, R. and Brinton, R.D. (2010) Clinically Relevant Progestins Regulate Neurogenic and Neuroprotective Responses In Vitro and In Vivo. Endocrinology 151(12):5782-5794. PMID: 20943809.
  16. Zhao, L., Yao, J., Mao, Z., Chen, S., Wang, Y. and Brinton, R.D. (2011) 17-Estradiol Regulates Insulin-Degrading Enzyme Expression via ER/PI3-K Pathway in Hippocampus: Relevance to Alzheimer’s Prevention. Neurobiol Aging 32:1949-1963. PMID: 20053478.
  17. Zhao, L., Mao, Z., Schneider, L.S. and Brinton, R.D. (2011) Estrogen Receptor-Selective Phytoestrogenic Formulation Prevents Physical and Neurological Changes in a Preclinical Model of Human Menopause. Menopause 18(10):1131-1142. PMID: 21738079.
  18. Bali, N., Arimoto, J.M., Iwata, N., Lin, S.W., Zhao, L., Brinton, R.D., Morgan, T.E. and Finch, C.E. (2012) Differential Responses of Progesterone Receptor Membrane Component-1 (Pgrmc1) and the Classical Progesterone Receptor (Pgr) to 17ß-Estradiol and Progesterone in Hippocampal Subregions that Support Synaptic Remodeling and Neurogenesis. Endocrinology 153(2):759-769. PMID: 22147012.
  19. Jayaraman, A., Carroll, J.C., Morgan, T.E., Lin, S., Zhao, L., Arimoto, J.M., Murphy, M.P., Beckett, T.L., Finch, C.E., Brinton, R.D. and Pike, C.J. (2012) 17-Estradiol and Progesterone Regulate Expression of -Amyloid Clearance Factors in Primary Neuron Cultures and Female Rat Brain. Endocrinology 153(11):5467-5479. PMID: 22962256.
  20. Zhao, L., Morgan, T.E., Mao, Z., Lin, S., Cadenas, E., Finch, C.E., Pike, C.J., Mack, W.J. and Brinton, R.D. (2012) Continuous versus Cyclic Progesterone Exposure Differentially Regulates Hippocampal Gene Expression and Functional Profiles. PLoS ONE 7(2): e31267. PMID: 22393359.
  21. Ding, F., Yao, J., Zhao, L., Mao, Z., Chen, S. and Brinton, R.D. (2013) Ovariectomy Induces a Shift in Fuel Availability and Metabolism in the Hippocampus of the Female Transgenic Model of Familial Alzheimer's. PLoS ONE 8(3):e59825. PMID: 23555795.
  22. Zhao, L., Mao, Z., Chen, S., Schneider, L.S. and Brinton, R.D. (2013) Early Intervention with an Estrogen Receptor-Selective Phytoestrogenic Formulation Prolongs Survival, Improves Spatial Recognition Memory, and Slows Progression of Amyloid Pathology in a Female Mouse Model of Alzheimer’s Disease. J Alzheimer Dis 37(2):403-419. PMID: 23428542.

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