The University of British Columbia, Canada

Email: caigan@mail.ubc.ca

1990 M.Phil., School of Biological Sciences, University of Wales, UK

1984 B.Sc., Department of Biology, Jiangxi University, China

Publications

1. Caigan Du: Transforming growth factor-beta in kidney transplantation: A double-edged sword (Chapter 13). In: Magdalene Trzcinska (ed.), Kidney Transplantation – New Perspectives. Intech, Croatia, pp223-234.
2. Christopher Y.C. Nguan and Caigan Du: Renal tubular epithelial cells as immunoregulatory cells in renal allograft rejection. Transplant Rev (Orlando). 2009 Jul;23(3):129-38.
3. Qiunong Guan, Shuyuan Li, Gordon Yip, Martin E. Gleave, Christopher YC Nguan and Caigan Du. Decrease in donor heart injury by recombinant clusterin protein in cold preservation with University of Wisconsin solution. Surgery. 151(3): 364-71. 2012.
4. Hao Wang, Qiunong Guan, Zhu Lan, Shuyuan Li, Wei Ge, Huifang Chen, Christopher YC Nguan, and Caigan Du. Prolonged renal allograft survival by donor interleukin-6 deficiency: Association with decreased alloantibodies and increased intragraft T regulatory cells. Am J Physiol Renal Physiol 302(2): F276-83. 2012.
5. Shuyuan Li, Qiunong Guan, Zhishui Chen, Martin E. Gleave, Christopher YC Nguan and Caigan Du. Reduction of cold ischemia-reperfusion injury by graft-expressing clusterin in heart transplantation. J Heart Lung Transplant. 2011 Jul;30(7):819-26. Epub 2011 Apr 22.
6. Qiunong Guan, Christopher Y.C. Nguan and Caigan Du. Expression of transforming growth factor-beta1 limits renal ischemia-reperfusioninjury. Transplantation. 2010 Jun 15;89(11):1320-7.
7. Wenjun Zhou, Qiunong Guan, Chris C.H. Kwan, Huifang Chen, Martin E. Gleave, Christopher Y.C. Nguan and Caigan Du: Loss of Clusterin Expression Worsens Renal Ischemia Reperfusion Injury. Am J Physiol Renal Physiol. 2010 Mar;298(3):F568-78. Epub 2009 Dec 9..
8. Shuang Wang, Jifu Jiang, Qiunong Guan, Hao Wang, Christopher YC Nguan, Anthony M. Jevnikar and Caigan Du. Reduction of chronic allograft nephropathy by inhibition of extracellular signal-regulated kinases1/2 signaling. Am J Physiol Renal Physiol. 2008, 295:F672-679.
9. Kanishka Mohibi, Shuang Wang, Qiunong Guan, Andrew Mellor, Hangtao Sun, Caigan Du and Anthony M Jevnikar. Indoleamine 2,3-dioxygenase (IDO) activity promotes renal ischemia reperfusion injury. Am. J. Physiol. Renal Physiol. 2008, 295: F226-234.
10. Shuang Wang, Jifu Jiang, Qiunong Guan, Zhu Lan, Hao Wang, Christopher YC Nguan, Anthony M. Jevnikar and Caigan Du. Reduction of Foxp3-expressing Regulatory T Cell Infiltrates During the Progression of Renal Allograft Rejection in a Mouse model. Transplant Immunol. 2008, 19: 93-102.
11. Shuang Wang, Hong Diao, Qiunong Guan, William W, Cruikshank, Terry L. Delovitch, Anthony M. Jevnikar and Caigan Du. Decreased renal ischemia-reperfusion injury by IL-16 inactivation. Kidney Int. 2008, 73: 318-326.
12. Kanishka Mohibi, Qiunong Guan, Hong Diao, Caigan Du and Anthony M Jevnikar. Pro-apoptotic activity of indoleamine 2,3-dioxygenase (IDO) expressed in renal tubular epithelial cells. Am. J. Physiol. Renal Physiol. 2007, 293: F801-F812.
13. Shuang Wang, Hong Diao, Qiunong Guan, Anthony M. Jevnikar and Caigan Du. Enhanced cardiac allograft survival by Vav1-Rac signaling blockade in a mouse model. Transplant Immunol. 2007, 18: 53-61.
14. Shuang Wang, Qiunong Guan, Hong Diao, Dameng Lian, Robert Zhong, Anthony M. Jevnikar and Caigan Du. Prolongation of cardiac allograft survival by inhibition of ERK1/2 signaling in a mouse model. Transplantation 2007, 83: 323-332.
15. Caigan Du, Jifu Jiang, Qiunong Guan, Hong Diao, Ziqin Yin, Robert Zhong and Anthony M Jevnikar*. NOS2 (iNOS) deficiency in kidney donor accelerates allograft loss in a murine model. Am. J. Transplant. 2007, 7: 17-26.
16. Caigan Du, Shuang Wang, Hong Diao, Qiunong Guan, Robert Zhong and Anthony M. Jevnikar*. Increasing Resistance of Tubular Epithelial Cells to Apoptosis by shRNA Therapy Ameliorates Renal Ischemia-Reperfusion Injury. Am. J. Transplant. 2007, 6: 2256-2267.
17. Caigan Du, Qiunong Guan, Hong Diao, Ziqin Yin and Anthony M. Jevnikar*. Nitric oxide induces apoptosis in renal tubular epithelial cells (TEC) through activation of caspase-8. Am. J. Physiol. Renal Physiol. 2006, 290: F1044-F1054.
18. Caigan Du, Qiunong Guan, Ziqin Yin, Robert Zhong and Anthony M. Jevnikar*. IL-2 mediated apoptosis of renal tubular epithelial cells (TEC) is regulated by the endogenous caspase-8 inhibitor c-FLIP. Kidney Int. 2005, 67:1397-1409.
19. Caigan Du, Jifu Jiang, Qiunong Guan, Ziqin Yin, Mark Masterson, Robert Zhong,Anthony M. Jevnikar. Renal tubular epithelial cell (TEC) self-injury through Fas/Fas ligand (FasL) interaction promotes renal allograft injury. Am. J. Transplant. 2004, 4: 1583-1594.