Dr. Qingming Dong
Department of Pharmacology
The University of Tennessee Health Science Center, USA
Research Associate
Email: qdong4@uthsc.edu
Qualifications
2005-2008 Ph.D., Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, China
1998-2001 M.S., Department of Microbiology, Peking University Health Science Center, China
1993-1998 M.D., Clinical Medicine, North China Coal Medical University, China
Publications (Selected)
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Deng X, Zhang W, O-Sullivan I, Williams JB, Dong Q, Park EA, Raghow R, Unterman TG, and Elam MB. FoxO1 Inhibits Sterol Regulatory Element Binding Protein-1c gene expression via the transcription factors Sp1 and SREBP-1c. J Biol Chem, 287 (24): 20132-20143 2012
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Li NL, Dong Q, Wei D, Pfeffer SR, Fan M, Pfeffer LM, Li K.. Activation of chemokine and inflammatory cytokine response in hepatitis C virus-infected hepatocytes depends on toll-like receptor 3 sensing of hepatitis C virus double-stranded RNA intermediates. Hepatology, 55(3):666-75 2012
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Zhou Z, Wang N, Woodson SE, Dong Q, Wang J, Liang Y, Rijnbrand R, Wei L, Nichols JE, Guo JT, Holbrook MR, Lemon SM, Li K. Antiviral activities of ISG20 in positive-strand RNA virus infections. Virology, 409 (2):175-88 2011
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Wang N, Dong Q, Li J, Jangra RK, Fan M, Brasier AR, Lemon SM, Pfeffer LM, Li K. Viral induction of the zinc-finger antiviral protein is IRF3-dependent but NF-{kappa}B-independent. J Biol Chem, 285(9):6080-90 2010
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Dong Q, Liu Z, Chen Y, Chan CY, Lin MC, Kung HF, Chan HL, Sung JJ, He ML. High level virion production and surface antigen expression with 1.5 copies of hepatitis B viral genome. J Virol Methods, 159:135-40 2009
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Dong Q, Xu B, Tan Y, Liu Z, Tian L, Zhang B, Lin CK, Kung HF, Sung JJ, He ML. The genetic variability of MDR1 C3435T polymorphisms in four Southern Chinese populations. Biomed Pharmacother, 63:658-62 2009
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Li Z, He ML, Yao H, Dong QM, Chen YC, Chan CY, Zheng BJ, Yuen KY, Peng Y, Sun Q, Yang X, Lin MC, Sung JJ, Kung HF. Inhibition of HBV replication and gene expression in vitro and in vivo with a single AAV vector delivering two shRNA molecules. BMB Rep, 42:59-64 2009
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Dong Q, Liu Z, Chan DP, Zhang B, Kung HF, Chan HL, Sung JJ, He ML. A1762T and G1764A mutations of hepatitis B virus, associated with increased risk of hepatocellular carcinoma, reduce the enhancer II/basal core promoter activities. Biochem Biophys Res Commun, 374: 773-776 2008
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Li Z, Yao H, Ma Y, Dong Q, Chen Y, Peng Y, Zheng BJ, Huang JD, Chan CY, Lin MC, Sung JJ, Yuen KY, Kung HF, He ML. Inhibition of HBV gene expression and replication by stably expressed interferon-alpha1 via adeno-associated viral vectors. J Gene Med, 10(6):619-27 2008
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Liu Z, Sun Y, Dong Q, He M, Cheng CH, Fan F. A novel TSHR gene mutation (Ile691Phe) in a Chinese family causing autosomal dominant non-autoimmune hyperthyroidism. J Hum Genet, 53(5):475-478 2008
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Xu BY, Guo LP, Lee SS, Dong QM, Tan Y, Yao H, Li LH, Lin CK, Kung HF, He ML. Genetic variability of CYP2B6 polymorphisms in four southern Chinese populations. World J Gastroenterol, 13(14):2100-3 2007
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He Z, Zhuang H, Zhao C, Dong Q, Peng G, Dwyer DE. Using patient-collected clinical samples and sera to detect and quantify the severe acute respiratory syndrome coronavirus (SARS-CoV). Virol J, 27(4):32 2007,
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Du H, Li T, Zhang HY, He ZP, Dong QM, Duan XZ, Zhuang H. Correlation of hepatitis B virus (HBV) genotypes and mutations in basal core promoter/precore with clinical features of chronic HBV infection. Liver Int, 27:240-246 2007
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He Z, Zhao C, Dong Q, Zhuang H, Song S, Peng G, Dwyer DE. Effects of severe acute respiratory syndrome (SARS) coronavirus infection on peripheral blood lymphocytes and their subsets. Int J Infect Dis, 9(6):323-30 2005
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He Z, Dong Q, Zhuang H, Song S, Peng G, Luo G, Dwyer DE. Kinetics of severe acute respiratory syndrome (SARS) coronavirus-specific antibodies in 271 laboratory-confirmed cases of SARS. Clin Diagn Lab Immunol, 11(4): 792-794 2004
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He Z, Zhuang H, Wang X, Song S, Dong Q, Yan J, Buehring GC, Luo G. Retrospective analysis of non-A-E hepatitis: possible role of hepatitis B and C virus infection. J Med Virol, 69:59-65 2003