Dr. Meiqing Shi
Virginia-Maryland Regional College of Veterinary Medicine
University of Maryland, College Park, Maryland, USA
Assistant Professor

Email: mshi@umd.edu

Qualifications

1995–2000   Ph.D., Faculty of Veterinary Medicine, JustusLiebig University of Giessen, Germany
1985–1988   M.Sc., College of Veterinary Medicine, South China Agricultural University, China
1981-1985   B.Sc., College of Veterinary Medicine, Hunan Agricultural University, China

Publications (Selected)

1. Liu, G., Xu, J., Wu, H., Sun, D., Zhang X., Zhu, X., Magez, S.,Shi, M.IL-27 signaling is crucial for survival of mice infected with African trypanosomes via preventing lethal effects of CD4+T cells and IFN-γ. PLOS Pathogens, in press, 2015
2. Liu, G., Sun, D., Wu, H., Zhang, M., Huan, H., Xu, I., Zhang X., Zhou, H.,Shi, M.Distinct contributions of CD4+and CD8+T cells to pathogenesis of Trypanosoma brucei infection in the context of gamma interferon and Interleukin-10. Infection and Immunity, 83: 2785-2795, 2015
3. Wu, F., Zhao, Y., Jiao, T., Shi, D., Zhu, X., Zhang, M., Shi, M., Zhou, H. CXCR2 is essential for cerebral endothelial activation and leukocyte recruitment during neuroinflammation. Journal of Neuroinflammation, 12:98, 2015
4. Li, S.S., Kyei, S.K., Timm-McCann, M., Ogbomo, H., Jones, G.J.,Shi, M., Xiang, R.F., Oykhman, P., Huston, S.M., Gill, M.J., Robbins, S.M., & Mody, C.H. The NK Receptor NKp30 Mediates Direct Fungal Recognition and Killing and Is Diminished in NK Cells from HIV-Infected Patients. Cell Host Microbe, 14: 387-397, 2013
5. Moriarty, T.J.,Shi, M., Lin Y.P., Ebady, R., Zhou, H., Odisho, T., Hardy, P.O., Salman-Dilgimen, A., Wu, J., Weening, E.H., Skare, J.T., Kubes, P., Leong, J., & Chaconas, G. Vascular binding of a pathogen under shear force through mechanistically distinct sequential interactions with host macromolecules. Molecular Microbiology, 86: 1116-1131, 2012
6. Shi, M., Calaruso P. & Mody, C.H. Real-time in vivo imaging of fungal migration to the CNS. Cellular Microbiology, 14: 1819-1827, 2012
7. Shi M.,Wang A, Prescott D, Waterhouse C, Zhang S, McDougall JJ, Sharkey KA, McKay DM. Infection with an intestinal helminth parasite reduces Freund’s complete adjuvant-induced mono-arthritis in mice. Arthritis & Rheumatism, 63: 434-444, 2011
8. Shi M., Li SS, Zheng CF, Jones GJ, Kim KS, Zhou, Z, Kubes P,  Mody CH.  Real-time imaging of trapping and urease-dependent transmigration ofCryptococcus neoformansin mouse brain. Journal of Clinical Investigation, 120: 1683-1693, 2010
9. Tabel H, Wei G,Shi M.T cells and immunopathogenesis of experimental African trypanosomiasis. Immunological Reviews,225: 128-139, 2008
10. Zheng CF, Jones GJ,Shi M., Wiseman JC, Marr KJ, Berenger BM, Huston SM, Gill MJ, Krensky AM, Kubes P, Mody CH.Late expression of granulysin by microbicidal CD4+T cells requires PI3K- and STAT5-dependent expression of IL-2Rbeta that is defective in HIV-infected patients. Journal of Immunology,180: 7221-7229, 2008
11. Shi M., Ye Z, Umeshappa KS, Moyana T, Xiang J. (2007) Alpha tumor necrosis factor contributes to CD8+T cell survival in the transition phase. Biochemical and Biophysical Research Communications, 360: 702-707, 2007
12. Shi M., Wei G, Tabel H.Trypanosoma congolenseInfections: MHC class II-restricted immune responses mediate either protection or disease, depending on IL-10 function. Parasite Immunology, 29: 107-111, 2007
13. Shi M., Wang CR, Wei G., Pan P, Appleyard G, Tabel H.Experimental African trypanosomiasis: lack of effective CD1d-restricted antigen presentation.Parasite Immunology,28: 643-647, 2006
14. Shi, M., Hao, S., Chan, T. & Xiang, J. CD4+T cells stimulate memory CD8+T cell expansion via acquired pMHC I complexes and costimulatory molecules, and IL-2 secretion. Journal of Leukocyte Biology, 80: 1354-1363, 2006
15. Shi, M. & Xiang, J. CD4+T cell-independent maintenance and expansion of memory CD8+T cells derived from in vitro dendritic cell activation. International Immunology,18: 887-895, 2006
16. Shi M, Wei G, Pan W, Tabel H.Experimental African trypanosomiasis: a subset of pathogenic, IFN-g-producing, MHC-II-restricted CD4+T cells mediates early mortality in highly susceptible mice.Journal of Immunology,176: 1724-1732, 2006
17. Pan W, Ogunremi O, Wei G,Shi M, Tabel H. CR3 (CD11b/CD18) is the major macrophage receptor for IgM antibody-mediated phagocytosis of African trypanosomes: diverse effect on subsequent synthesis of TNF-α and nitric oxide. Microbes and Infection,8: 1209-1218, 2006
18. Shi M, Wei G., Pan W, Tabel H. Impaired Kupffer cells in highly susceptible mice infected withTrypanosoma congolense.Infection and Immunity,73: 8393-8396, 2005
19. Shi M., Wei G., Pan P, Tabel H.Trypanosoma congolenseinfections: antibody-mediated phagocytosis by Kupffer cells. Journal of Leukocyte Biology, 76: 399-405, 2004
20. Shi M., Pan W, Tabel H. Experimental African trypanosomiasis: IFN-gmediates early mortality. European Journal of Immunology, 33: 108-118, 2003
21. Shi M., Hirzmann J, Dafaalla TH, Zahner H. In vivo expression profiles of cytokine and iNOS mRNAs in rats infected withEimeria separata. Veterinary Parasitology, 97: 131-140 2001
22. Shi M., Huther S, Burkhardt E, Zahner H. Lymphocyte subpopulations in the caecum mucosa of rats after infections withEimeria separata: early responses in naïve and immune animals to primary and challenge infections. International Journal for Parasitology, 31: 49-55 2001