Prof. Rob Krams

Imperial College London, UK



1990-1993 Post Doc, ErasmusMC Rotterdam, the Netherlands

1988-1990 Post Doc, John Hopkins Medical Institutions, USA

1984-1988 PhD, Free University Amsterdam, the Netherlands

Publications (Slected)

  1. van Bochove, G.S., et al., Contrast enhancement by differently sized paramagnetic MRI contrast agents in mice with two phenotypes of atherosclerotic plaque. Contrast Media Mol Imaging, 2010.
  2. Debernardi, N., et al., Microcalcifications in atherosclerotic lesion of apolipoprotein E-deficient mouse. Int J Exp Pathol, 2010.
  3. Plata, A.M., S.J. Sherwin, and R. Krams, Endothelial nitric oxide production and transport in flow chambers: The importance of convection. Ann Biomed Eng, 2010. 38(9): p. 2805-2816.
  4. Helderman, F., et al., Predicting patient-specific expansion of abdominal aortic aneurysms. Eur J Vasc Endovasc Surg, 2010. 40(1): p. 47-53.
  5. Friedman, M.H., R. Krams, and K.B. Chandran, Flow interactions with cells and tissues: cardiovascular flows and fluid-structure interactions. Sixth International Bio-Fluid Mechanics Symposium and Workshop, March 28-30, 2008, Pasadena, California. Ann Biomed Eng, 2010. 38(3): p. 1178-1187.
  6. van Bochove, G.S., et al., MRI-determined carotid artery flow velocities and wall shear stress in a mouse model of vulnerable and stable atherosclerotic plaque. MAGMA, 2010. 23(2): p. 77-84.
  8. Friedman, M.H., R. Krams, and K.B. Chandran, Flow Interactions with Cells and Tissues: Cardiovascular Flows and Fluid-Structure Interactions : Sixth International Bio-Fluid Mechanics Symposium and Workshop, March 28-30, 2008, Pasadena, California. Ann Biomed Eng, 2010.
  9. Chaudhury, H., et al., c-Jun N-terminal kinase primes endothelial cells at atheroprone sites for apoptosis. Arterioscler Thromb Vasc Biol, 2010. 30(3): p. 546-553.
  10. Krams, R., et al., Shear stress is associated with markers of plaque vulnerability and MMP-9 activity. EuroIntervention, 2006. 2(2): p. 250-256.
  11. Zakkar, M., et al., Activation of Nrf2 in endothelial cells protects arteries from exhibiting a proinflammatory state. Arterioscler Thromb Vasc Biol, 2009. 29(11): p. 1851-1857.
  12. Cheng, C., et al., Activation of MMP8 and MMP13 by angiotensin II correlates to severe intra-plaque hemorrhages and collagen breakdown in atherosclerotic lesions with a vulnerable phenotype. ATHEROSCLEROSIS, 2009. 204(1): p. 26-33.
  13. de Crom, R., et al., Large variations in absolute wall shear stress levels within one species and between species. ATHEROSCLEROSIS, 2009. 204(1): p. 16-17.
  14. Susa, D., et al., Donor pre-treatment with tacrolimus reduces transplant vasculopathy. PHARMACOL RES, 2009. 59(4): p. 273-278.
  15. Robbers-Visser, D., et al., Pulmonary Artery Size and Function After Fontan Operation at a Young Age. J MAGN RESON IMAGING, 2008. 28(5): p. 1101-1107.
  16. Segers, D., P. Weinberg, and R. Krams, Atherosclerosis: cell biology and lipoproteins--shear stress and inflammation in plaque formation: new evidence. Curr Opin Lipidol, 2008. 19(6): p. 627-628.
  17. Helderman, F., et al., A numerical model to predict abdominal aortic aneurysm expansion based on local wall stress and stiffness. MED BIOL ENG COMPUT, 2008. 46(11): p. 1121-1127.
  18. Segers, D., et al., A primer on the immune system in the pathogenesis and treatment of atherosclerosis. EuroIntervention, 2008. 4(3): p. 378-390.
  19. Krams, R., M. Breeuwer, and F. van de Vosse, Personalised imaging and biomechanical modelling of large vessels. Med Biol Eng Comput, 2008. 46(11): p. 1057-1058.
  20. Breeuwer, M., et al., Towards patient-specific risk assessment of abdominal aortic aneurysm. Med Biol Eng Comput, 2008. 46(11): p. 1085-1095.
  21. Ridger, V., et al., Hemodynamic parameters regulating vascular inflammation and atherosclerosis: a brief update. Biomed Pharmacother, 2008. 62(8): p. 536-540.
  22. Zakkar, M., et al., Increased endothelial mitogen-activated protein kinase phosphatase-1 expression suppresses proinflammatory activation at sites that are resistant to atherosclerosis. CIRC RES, 2008. 103(7): p. 726-732.
  23. Cheng, C., et al., Rapamycin modulates the eNOS vs. shear stress relationship. CARDIOVASC RES, 2008. 78(1): p. 123-129.
  24. da Silva, R.F., et al., Role of arginase pathway in response to shear stress: new potential therapeutic targets for atherosclerosis? EUR J CLIN INVEST, 2008. 38: p. 36-36.
  25. Foin, N., P. Evans, and R. Krams, Atherosclerosis: cell biology and lipoproteins - new developments in imaging of inflammation of the vulnerable plaque. CURR OPIN LIPIDOL, 2008. 19(1): p. 98-100.
  26. Van der Heiden, K., et al., Endothelial primary cilia in areas of disturbed flow are at the base of atherosclerosis. ATHEROSCLEROSIS, 2008. 196(2): p. 542-550.
  27. Cheng, C., et al., Large variations in absolute wall shear stress levels within one species and between species. Atherosclerosis, 2007. 195(2): p. 225-235.
  28. Goertz, D.E., et al., Subharmonic contrast intravascular ultrasound for vasa vasorum imaging. Ultrasound Med Biol, 2007. 33(12): p. 1859-1872.
  29. Helderman, F., et al., Effect of shear stress on vascular inflammation and plaque development. Curr Opin Lipidol, 2007. 18(5): p. 527-533.
  30. Susa, D., et al., Donor pre-treatment with tacrolimus reduces transplant vasculopathy. TRANSPL INT, 2007. 20: p. 141-141.
  31. Jackson, C.L., et al., Assessment of unstable atherosclerosis in mice. Arterioscler Thromb Vasc Biol, 2007. 27(4): p. 714-720.
  32. Cheng, C., et al., Shear stress-induced changes in atherosclerotic plaque composition are modulated by chemokines. J CLIN INVEST, 2007. 117(3): p. 616-626.
  33. Segers, D., et al., Gelatinolytic activity in atherosclerotic plaques is highly localized and is associated with both macrophages and smooth muscle cells in vivo. CIRCULATION, 2007. 115(5): p. 609-616.
  34. Goertz, D.E., et al., Vasa vasorum and molecular imaging of atherosclerotic plaques using nonlinear contrast intravascular ultrasound. NETH HEART J, 2007. 15(2): p. 77-80.
  35. Kofflard, M.J., et al., Coronary flow reserve in hypertrophic cardiomyopathy: relation with microvascular dysfunction and pathophysiological characteristics. Neth Heart J, 2007. 15(6): p. 209-215.
  36. Cheng, C., et al., Response to letter regarding article, "Atherosclerotic lesion size and vulnerability are determined by patterns of fluid shear stress". CIRCULATION, 2006. 114(22): p. E615-E615.
  37. Frijlink, M.E., et al., Harmonic intravascular ultrasound imaging with a dual-frequency catheter. Ultrasound Med Biol, 2006. 32(11): p. 1649-1654.
  38. Frijlink, M.E., et al., Intravascular ultrasound tissue harmonic imaging in vivo. IEEE T ULTRASON FERR, 2006. 53(10): p. 1844-1852.
  39. Goertz, D.E., et al., Contrast harmonic intravascular ultrasound: a feasibility study for vasa vasorum imaging. Invest Radiol, 2006. 41(8): p. 631-638.
  40. Cheng, C., et al., Atherosclerotic lesion size and vulnerability are determined by patterns of fluid shear stress. CIRCULATION, 2006. 113(23): p. 2744-2753.
  41. Nette, R.W., et al., Norepinephrine-induced vasoconstriction results in decreased blood volume in dialysis patients. NEPHROL DIAL TRANSPL, 2006. 21(5): p. 1305-1311.
  42. Cheng, C., et al., Shear stress affects the intracellular distribution of eNOS: direct demonstration by a novel in vivo technique. BLOOD, 2005. 106(12): p. 3691-3698.
  43. Davies, P.F., J.A. Spaan, and R. Krams, Shear stress biology of the endothelium. Ann Biomed Eng, 2005. 33(12): p. 1714-1718.
  44. Ie, E.H., et al., Myocardial contractility does not determine the haemodynamic response during dialysis. Nephrol Dial Transplant, 2005. 20(11): p. 2465-2471.
  45. Krams, R., et al., In vivo temperature heterogeneity is associated with plaque regions of increased MMP-9 activity. EUR HEART J, 2005. 26(20): p. 2200-2205.
  46. Wentzel, J.J., et al., Geometry guided data averaging enables the interpretation of shear stress related plaque development in human coronary arteries. J BIOMECH, 2005. 38(7): p. 1551-1555.
  47. Krams, R., et al., Effect of vessel curvature on Doppler derived velocity profiles and fluid flow. Ultrasound Med Biol, 2005. 31(5): p. 663-671.
  48. Wentzel, J.J., R. Krams, and C.J. Slager, Letter regarding article by Korshunov and Berk, "Strain-dependent vascular remodeling: The 'Glagov phenomenon' is genetically determined". CIRCULATION, 2005. 111(9): p. E119-E119.
  49. Schaar, J.A., et al., Three-dimensional palpography of human coronary arteries - Ex vivo validation and in-patient evaluation. HERZ, 2005. 30(2): p. 125-133.
  50. Krams, R., et al., Diastolic coronary vascular reserve: a new index to detect changes in the coronary microcirculation in hypertrophic cardiomyopathy. J Am Coll Cardiol, 2004. 43(4): p. 670-677.
  51. Verheye, S., et al., Intravascular thermography: Immediate functional and morphological vascular findings. Eur Heart J, 2004. 25(2): p. 158-165.
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