Dr. Lei Xue

School of Life Science and Technology
Tongji University, Shanghai, China

Professor for Developmental Biology & Genetics



1998 Ph.D., Molecular Biology and Genetics, University of Zürich, Switzerland

1990 M.S., Developmental Biology, Chinese Academy of Science, China

1980 B.S., Cell Biology, Beijing University, China Research Fields Alzheimer’s Disease (AD) Cell Death and Migration Tumor Metastasis

Publications (selected)

  1. X Ma, Y Chen, W Xu, N Wu, M Li, Y Cao, S Wu, Q Li and L Xue* (2015) Impaired Hippo signaling promotes Rho1-JNK-dependent growth. Proc. Natl. Acad. Sci. USA 112: 1065-70.
  2. X Ma, Y Chen, S Zhang, W Xu, Y Shao, Y Yang, W Li, M Li and L Xue* (2015) Rho1–Wnd signaling regulates loss-of-cell polarity-induced cell invasion in Drosophila. Oncogene 34, doi: 10.1038/onc.2015.137.
  3. X Ma, W Xu, D Zhang, Y Yang, W Li and L Xue* (2015). Wallenda regulates JNK-mediated cell death in Drosophila. Cell Death Disease 6, e1737.
  4. S Zhang, C Chen, C Wu, Y Yang, W Li and L Xue* (2015) The canonical Wg signaling modulates Bsk-mediated cell death in Drosophila. Cell Death Disease 6, e1713.
  5. Y Hu, Y Han, Y Shao, X Wang, Y Ma, E Ling and L Xue* (2015) Gr33a Modulates Drosophila Male Courtship Preference. Scientific Reports 5: 7777.
  6. L Li, P Li and L Xue* (2015) The RED domain of Paired is specifically required for Drosophila accessory gland maturation. Open Biology 5: 140179.
  7. X Wang, Y Ma, Y Zhao, Y Chen, Y Hu, C Chen, Y Shao and L Xue* (2015) APLP1 promotes dFoxO-dependent cell death in Drosophila. Apoptosis 20: 778-786.
  8. X Wang, Z Wang, Y Chen, X Huang, Y Hu, R Zhang, M S Ho and L Xue* (2014)FoxO Mediates APP-Induced AICD-Dependent Cell Death. Cell Death Disease 5, e1233.
  9. Y Hu, Y Han, X Wang and L Xue* (2014) Aging-related Neurodegeneration Eliminates Male Courtship Choice in Drosophila. Neurobiology of Aging 35, 2174-2178.
  10. X Ma, W Li, H Yu, Y Yang, M Li, L Xue* and T Xu* (2014) Bendless modulates JNK-mediated cell death and migration in Drosophila. Cell Death Diff. 21, 407-415.
  11. X Ma, Y Shao, H Zheng, M Li, W. Li and L. Xue* (2013) Src42A modulates tumor invasion and cell death via Ben/dUev1a-mediated JNK activation in Drosophila. Cell Death Disease 4, e864.
  12. H. Yang, W. Li, H. Yu, R. Yuan, Y. Yang, K. Pung, P. Li and L. Xue* (2013) Physiological Effects of L-Theanine on Drosophila melanogaster. Molecules 18, 13175-13187.
  13. X. Ma, L. Yang, Y. Yang, M. Li, W. Li* and L. Xue* (2013) dUev1a Modulates TNF-JNK Mediated Tumor Progression and Cell Death in Drosophila. Dev. Biol. 380, 211-221.
  14. X. Ma, J. Huang, Y. Yang, W. Li and L. Xue* (2012) NOPO Modulates Egr- induced JNK- independent cell death in Drosophila. Cell Research 22, 425-431.
  15. J. Liu*, M. Ghanim*, L. Xue* et al., (2009) Analysis of Drosophila Segmentation Network Identifies a JNK Pathway Factor Overexpressed in Kidney Cancer. Science 323: 1218-1222. (* Equal contribution).
  16. L. Xue, T. Igaki, E. Kuranaga, H. Kanda, M. Miura and T. Xu (2007) Tumor suppressor CYLD regulates JNK-induced cell death in Drosophila. Dev. Cell 13: 446-454.
  17. L. Xue and M. Noll. (2002) Dual role of the Pax gene paired in accessory gland development of Drosophila. Development 129: 339-46.
  18. L. Xue, X. Li and M. Noll. (2001) Multiple protein functions of paired in Drosophila development and their conservation in the Gooseberry and Pax3 homologs. Development 128: 395-405.
  19. L. Xue and M. Noll. (2000) Drosophila female sexual behavior induced by sterile males showing copulation complementation. Proc. Natl. Acad. Sci. USA 97: 3272-3275.
  20. L. Xue and M. Noll. (1996) The functional conservation of proteins in evolutionary alleles and the dominant role of enhancers in evolution. EMBO. J., 15: 3722-3731.

Profile Details

Last Updated: 2015-07-06

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