Dr. Yasumasa Okada
Division of Internal Medicine
and Laboratory of Electrophysiology
Murayama Medical Center, Japan
Associate Professor
Email: yasumasaokada@1979.jukuin.keio.ac.jp
Qualifications
1987 Ph.D.,Keio University, Japan
1983 M.Sc., Keio
University, Japan
1979 B.Sc., Keio University, Japan
Publications(selected)
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Lal A,
Oku Y, Hülsmann S, Okada Y, Miwakeichi F, Kawai S, Tamura Y, Ishiguro M (2011)
Dual oscillator model of the respiratory neuronal network generating quantal
slowing of respiratory rhythm. Journal of Computational Neuroscience 30(2):
225-240.
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Miwakeichi
F, Oku Y, Okada Y, Kawai S, Tamura Y, Ishiguro M (2011) Detection and
visualization method of dynamic state transition for biological spatio-temporal
imaging data. IEEE Transactions on Medical Imaging (IEEE Trans Med Imaging)
30(3): 859-866.
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Koganezawa
T, Okada Y, Terui N, Paton JFR, Oku Y (2011) Aμ-opioid
receptor agonist DAMGO induces rapid breathing in the arterially-perfused in
situ preparation of rat. Respiratory Physiology and Neurobiology 177:207-211.
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Aoyama
R, Okada Y, Yokota S, Yasui Y, Fukuda K, Shinozaki Y, Yoshida H, Nakamura M,
Chiba K, Yasui Y, Kato F, Toyama Y (2011) Spatiotemporal and anatomical
analyses of P2X receptor-mediated neuronal and glial processing of sensory
signals in the rat dorsal horn. Pain 152: 2085-2097 [Epub ahead of print, June
11, 2011]
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Ishiguro
M, Kawai S, Okada Y, Oku Y, Miwakeichi F, Tamura Y, Lal A (2010) What does the
multi-peaked respiratory output pattern tell us about the respiratory pattern
generating neuronal network? Advances in Experimental Medicine and Biology 669:
235-238.
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Yokota
S, Shinozaki Y, Oku Y,Okada Y, Yasui Y (2010) Vesicular
glutamate transporter 2-immunoreactive synapses onto phrenic motoneurons in the
neonatal rat. Advances in Experimental Medicine and Biology 669: 189-192.
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Masumiya
H, Oku Y, Okada Y (2009).Inhomogeneous distribution of action potential
characteristics in the rabbit sino-atrial node revealed by voltage imaging.
Journal of Physiological Sciences 59: 227-241.
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Kawai
S, Oku Y, Okada Y, Miwakeichi F, Tamura Y, Ishiguro M (2009). A novel
statistical analysis of voltage-imaging data by structural time series modeling
and its application to the respiratory neuronal network. Neuroscience Research
63(3):165-171.
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Okada Y,
Yokota S, Shinozaki Y, Aoyama R, Yasui Y, Ishiguro M, Oku Y (2009).Anatomical
architecture and responses to acidosis of a novel respiratory neuron group in
the high cervical spinal cord (HCRG) of the neonatal rat. Advances in
Experimental Medicine and Biology 648: 387-394.
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Oku Y,
Kimura N, Masumiya H, Okada Y (2008).Spatiotemporal organization of
frog respiratory neurons visualized on the ventral medullary surface.
Respiratory Physiology and Neurobiology 161: 281-290.
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Aoki T,
Yamasawa F, Kawashiro T, Shibata T, Ishizaka A, Urano T, Okada Y (2008).Effects
of long-term low-dose oxygen supplementation on the epithelial function,
collagen metabolism and interstitial fibrogenesis in the guinea pig lung.
Respiratory Research 9:37 (e-publish only).
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Oyamada
Y, Murai M, Harada N, Ishizaka A, Okada Y (2008).Age-dependent involvement of
ATP-sensitive potassium channel Kir6.2 in hypoxic ventilatory depression of
mouse. Respiratory Physiology and Neurobiology 162: 80-84.
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Oku Y,
Okabe A, Hayakawa T, Okada Y (2008).Respiratory neuron group in
the high cervical spinal cord discovered by optical imaging. Neuroreport
19(17): 1739-1743.
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Nishii
Y, Okada Y, Yokoba M, Katagiri M, Yanaihara T, Masuda N, Easton PA, Abe T
(2008). Aminophylline increases parasternal intercostal muscle activity during
hypoxia in humans. Respiratory Physiology and Neurobiology 161: 69-75.
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Tsujita
M, Sakuraba S, Kuribayashi J, Hosokawa Y, Hatori E, Okada Y, Kashiwagi M,
Takeda J, Kuwana S (2008). Antagonism of morphine-induced central respiratory
depression by donepezil in anesthetized rabbit. Biological Research 40:
339-346.
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Umeda
A, Kawasaki K, Abe T, Watanabe M, Ishizaka A, Okada Y (2008). Hyperventilation
and finger exercise increase venous-arterial PCO2 and pH differences. American
Journal of Emergency Medicine 26: 975-980.
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Okada Y,
Masumiya H, Tamura Y, Oku Y (2007).Respiratory and metabolic
acidosis differentially affect the respiratory neuronal network in the ventral
medulla of neonatal rats. European Journal of Neuroscience 26: 2834-2843.
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Okada
Y, Kuwana S, Masumiya H, Kimura N, Chen Z, Oku Y (2007). Chemosensitive
neuronal network organization in the ventral medulla analyzed by dynamic
voltage-imaging. Advances in Experimental Medicine and Biology 605: 353-358.
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Oku Y,
Masumiya H, Okada Y (2007).Postnatal developmental changes in activation profiles
of the respiratory neuronal network in the rat ventral medulla. Journal of
Physiology 585(1):175-186.
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Fukuda
K, Okada Y, Yoshida H, Aoyama R, Nakamura M, Chiba K, Toyama Y (2006).
Ischemia-induced disturbance of neural network function in the rat spinal cord
analyzed by voltage-imaging. Neuroscience 140(4): 1453-1465.
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Kuwana
S, Tsunekawa N, Yanagawa Y, Okada Y, Kuribayashi J, Obata K (2006).
Electrophysiological and morphological characteristics of GABAergic respiratory
neurons in the mouse pre-Bötzinger complex. European Journal of Neuroscience
23(3): 667-674.
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Sakuraba
S, Kuwana S, Eriksson LI, Okada Y, Ochiai R, Kashiwagi M, Hatori E, Lindahl
SGE, Takeda J (2005). Effects of neuromuscular blocking agents on central
respiratory chemosensitivity in newborn rats. Biological Research 38(2-3):
225-233.
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Okada
Y, Kuwana S, Kawai A, Mückenhoff K, Scheid P (2005). Significance of
extracellular potassium in central respiratory control studied in the isolated
brainstem-spinal cord preparation of the neonatal rat. Respiratory Physiology
and Neurobiology 146(1): 21-32.