Dr. Georgi V. Petkov

Department of Pharmaceutical and Biomedical Sciences

South Carolina College of Pharmacy (SCCP)

University of South Carolina (USC), Columbia

Associate Professor



1997 Ph.D., Physiology, University of Sofia, Sofia, Bulgaria

1992 M.Sc., Biochemistry and Microbiology, University of Sofia, Bulgaria

Publications (selected)

  1. Petkov, G.V., Duridanova, D., Gagov, H. and Boev, K. (1994) Effects of sodium nitroprusside on the electrical and contractile activity of cat gastric antrum.Comp Rend Bulg Acad Sci,47, (9), 61-64.
  2. Duridanova, D., Gagov, H.,Petkov, G.V.,Shkodrov, G. and Boev, K. (1995) Cyclic GMP activation of potassium currents by sarcoplasmic reticulum Ca2+pump-dependent mechanism.Gen Physiol Biophys,14, 139-151.
  3. Petkov, G.V., Fusi, F., Boev, K. (1995). Effects of cyclopiazonic acid on the phasic and tonic contractions in the smooth muscles of the guinea pig and cat stomach.Comp Rend Bulg Acad Sci,48, (8), 57-60
  4. Petkov, G.V.and Boev, K. (1996). Participation of extracellular calcium in the cyclopiazonic acid-induced contraction of the cat gastric fundus.Comp Rend Acad Bulg Sci,49, (3), 75-78.
  5. Petkov, G.V.and Boev, K.K. (1996). The role of sarcoplasmic reticulum and sarcoplasmic reticulum Ca2+-ATPase in the smooth muscle tone of the cat gastric fundus.Pflugers Arch – Eur J Physiol., 431, 928-935.
  6. Petkov, G.V.and Boev, K. (1996). Cyclopiazonic acid-induced changes in contractile activity of smooth muscle strips isolated from cat and guinea-pig stomach.European Journal of Pharmacology,318, 109-115.
  7. Petkov, G.V.(1997). Function of sarcoplasmic reticulum as a buffer barrier to calcium in gastric fundus smooth muscles.Annu Univ Sofia,88(4), 248-252.
  8. Petkov, G.V., Ivanov R., Boev K. (1997).Effects of nitric oxide releasing sodium nitroprussibe and 3-morpholino-sydnonimine in gastric smooth muscles from guinea-pig.Annu Univ Sofia,88(4), 243-247.
  9. Petkov, G.V., Spassov, G.D., Boev, K.K. (1998). Role of sarcoplasmic reticulum in the myorelaxant activity of nitric oxide donors in guinea pig gastric fundus.European Journal of Pharmacology,354, 59-66.
  10. Petkov, G.V., Boev, K.K. (1998). The role of a ryanodine-sensitive Ca2+-store in the regulation of smooth muscle tone of the cat gastric fundus.General Physiology and Biophysics,17(3), 225-237.
  11. Fusi, F., Valoti, M.,Petkov, G.V., Boev, K.K., Sgaragli, G.P. (1998). Myorelaxant activity of 2-t-butyl-methoxyphenol (BHA) in guinea pig gastric fundus.European Journal of Pharmacology,360, (1), 43-50.
  12. Petkov, G.V.and Boev, K.K. (1999). Control of the phasic and tonic contractions of guinea pig stomach by a ryanodine-sensitive Ca2+ store.European Journal of Pharmacology,367(2-3): 335-341.
  13. Petkov, G.V.,Heppner, TJ, Bonev, AD, Herrera, GM, and Nelson, MT. (2001). Low Levels of KATPChannel Activation Decrease Excitability and Contractility of Urinary Bladder.Am J Physiol.,280,R1427-R1433.
  14. Petkov, G.V.,Fusi, F., Saponara, S., Gagov, H.S., Sgaragli G. and Boev, K.K. (2001). Characterization of plasma membrane calcium currents in freshly isolated smooth muscle cells from rat tail main artery.Acta Physiologica Scandinavica, 173 (3), 257-265.
  15. Petkov, G.V.,Bonev, A.D., Heppner, T.J., Brenner, R, Aldrich, RW, Nelson, M.T. (2001)b1-subunit of the Ca2+-activated K+channel regulates contractile activity of mouse urinary bladder smooth muscle.Journal of Physiology, 537 (2), 443-452.
  16. Herrera GM, Pozo MJ, Zvara P,Petkov, G.V.,Bond CT, Adelman JP, Nelson MT. (2003). Urinary bladder instability induced by selective suppression of the murine small conductance calcium-activated potassium (SK3) channel.Journal of Physiology,551(3), 893-903.
  17. Heppner, TJ, Bonev, AD, Eckman, DM, Gomez MF,Petkov, G.V.,Nelson, MT. (2005). Novel PPARgamma agonists GI 262570, GW 7845, GW 1929 and pioglitazone decrease calcium channel function and myogenic tone in rat mesenteric arteries.Pharmacology73 (1), 15-22.
  18. Petkov, G.V.and Nelson, M.T. (2005). Differential regulation of Ca2+-activated K+(BK)channelsbyb-adrenoceptors in guinea pig urinary bladder smooth muscle.Am J Physiology - Cell Physiology, 288 (6), C1255-C1263.
  19. Petkov, G.V.,Balemba O., Nelson, M.T. and G. M. Mawe (2005).Identification of a spontaneouslyactive, Na+-permeable channel in guinea pig gallbladder smooth muscle.Am J Physiology, Gastrointestinal & Liver Physiology289(3): G501-507
  20. Brown SM, Bentcheva-Petkova LM, Lei L,Hristov KL,Chen M,Kellett WF, Meredith A, Aldrich RW, Nelson MT &Petkov GV.(2008).Beta-adrenergic relaxation of mouse urinary bladder smooth muscle in the absence of large-conductance Ca2+-activated K+ channel.Am J Physiol—Renal Physiol.,295 (4): F1149-F1157
  21. Hristov, KL., Cui, XL., Brown, SM., Lei, L., Kellett, WF., &Petkov, GV.(2008).Stimulation of β3-adrenoceptors relaxes rat urinary bladder smooth muscle via activation of the large conductanceCa2+-activated K+(BK) channels.Am J Physiol—Cell Physiol.,295(5):C1344-C1353
  22. Chen, M.Y., andPetkov GV(2009).Identification of large conductance Ca2+-activated K+channel accessoryb4 subunit in rat and mouse urinary bladder smooth muscle.J. Urology182(1): 374-381.
  23. Chen, M.Y., Kellett, W.F., andPetkov GV(2010).Voltage-gated K+ channels sensitive to stromatoxin-1 regulate myogenic and neurogenic contractions of rat urinary bladder smooth muscle.Am J Physiol –Regul. Integr. Comp.Physiol.299 (1): R177-184
  24. Hristov, K.L., Chen, M., Kellett, W.F, Rovner, E.S.,Petkov, G.V.(2011).Large conductance voltage- and Ca2+-activated K+channels regulate human detrusor smooth musclefunction.Am. J. Physiol. –CellPhysiol.301 (4): C903-C912
  25. Soder, R.P. andPetkov, G.V.(2011).Large conductance Ca2+-activated K+channel activation with NS1619 decreases myogenic and neurogenic contractions of rat detrusor smooth muscle.Eur. J. Pharmacol.670 (1): 252-259

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