Xiao-Xin Yan

Department of Anatomy & Neurobiology
Central South University Xiangya School of Medicine, China




2013 Ph.D. in Neurobiology, Central South University, China

1990 Master’ s degree in Medicine, Hunan Medical University, China

1984 Bachelor of Medicine, Hunan Medical College, China

Publications (Selected)

  1. Yan XX, Ma C, Bao AM, Wang XM, Wei-Ping Gai (2015) Human brain banking as a cornerstone for neuroscience in China. Lancet Neurology, 14 (2): 136.
  2. Xue ZQ, He ZW, Yu JJ, Cai Y, Qiu WY, Pan A, Gai WP, Cai H, Luo XG, Ma C, Yan XX (2015) Non-neuronal and neuronal BACE1 elevation in association with angiopathic and leptomeningeal β-amyloid deposition in the human brain. BMC Neurol., 15(1): 71.
  3. Li JM, Cai Y, Liu F, Yan L, Hu X, Patrylo PR, Cai H, Luo XG, Xiao D, Yan XX (2015) Experimental microembolism induces localized neuritic pathology in guinea pig cerebrum. Oncotarget, 6(13): 10772-10785.
  4. Zhu HX, Xue ZQ, Qiu WY, Zeng ZJ, Dai JP, Ma C, Luo XG, Yan XX (2015) Age-related intraneuronal accumulation of αII-spectrin breakdown product SBDP-120 in the human cerebrum is enhanced in Alzheimer’s disease. Exp. Gerontol., 69: 43–52.
  5. Yan XX, Ma C, Gai WP, Cai H, Luo XG (2014): Can BACE1 Inhibition Mitigate Early Axonal Pathology in Neurological Diseases? J. Alzheimer’s Dis., 38: 705–718.
  6. Li JM, Liu C, Hu X, Cai Y, Ma C, Luo XG, Yan XX (2014) Inverse correlation between Alzheimer’s disease and cancer: Implication for a strong impact of regenerative propensity on neurodegeneration? BMC Neurology, 14 (1): 211.
  7. Deng XH, Li ML, Ai WM, He LX, Lu DH, Patrylo PR, Cai H, Luo XG, Li Z, Yan XX (2014) Lipolysaccharide-induced neuroinflammation is associated with Alzheimer-like amyloidogenic axonal pathology and dendritic degeneration in rats. Adv. Alzheimer’s Dis., 3(2): 78-93.
  8. Yang ZY, Li JM, Xiao L, Mou L, Cai Y, Huang H, Luo XG, Yan XX (2014) [3H]-L685,458 binding sites are abundant in multiple peripheral organs in rats: Implications for safety assessment of putative γ-secretase targeting drugs. Basic Clin. Pharmacol. Toxicol., 115 (6): 518-526.
  9. Liu F, Xue ZQ, Deng SH, Xiong K, Luo XG, Patrylo PR, Rose GM, Cai H, Struble RG, Cai Y, Yan XX (2013) γ-Secretase binding sites in aged and Alzheimer’s disease human cerebrum: The choroid plexus as a putative origin of CSF Aβ. Eur. J. Neurosci., 37 (10): 1714–1725.
  10. Li JM, Xue ZQ, Deng SH, Luo XG, Cai H, Cai Y, Yan XX (2013) Amyloid plaque pathogenesis in 5×FAD mouse spinal cord: Retrograde transneuronal modulation after peripheral nerve injury. Neurotox. Res., 24 (1): 1-14.
  11. Cai Y, Zhang XM, Macklin LN, Cai H, Luo XG, Oddo S, LaFerla FM, Struble RG, Rose GM, Patrylo PR, Yan XX (2012) BACE1 elevation is involved in amyloid plaque development in the triple transgenic model of Alzheimer’s disease: Differential Aβ antibody labeling of early-onset axonal terminal pathology. Neurotox. Res., 21 (2): 160-174.
  12. Yan XX, Cai Y, Zhang XM, Luo XG, Cai H, Rose GM, Patrylo PR (2012) BACE1 elevation is associated with aberrant limbic axonal sprouting in epileptic CD1 mice. Exp. Neurol., 235(1): 228-37.
  13. Cai Y, Xue ZQ, Zhang XM, Li MB, Wang H, Luo XG, Cai H, Yan XX (2012) An age-related axon terminal pathology around the first olfactory relay that involves amyloidogenic protein overexpression without plaque formation. Neuroscience, 215: 160–173.
  14. Cai Y, Zhu HX, Li JM, Luo XG, Patrylo PR, Rose GM, Streeter J, Hayes R, Wang KKW, Yan XX, Jeromin A (2012) Age-related intraneuronal elevation of αII-spectrin breakdown product SBDP-120 in rodent forebrain accelerates in the 3×Tg-AD mice. PLoS-ONE, 7 (6): e37599.
  15. Yan XX, Cai Y, Shelton J, Deng SH, Luo XG, Oddo S, LaFerla FM, Cai H, Rose GM & Patrylo PR (2012) Chronic temporal lobe epilepsy is associated with enhanced Alzheimer-like neuropathology in 3×Tg-AD mice. PLoS-ONE, 7 (11): e48782.
  16. Zhang XM, Xiong K, Cai Y, Cai H, Luo XG, Feng JC, Clough RW, Patrylo PR, Struble RG, Yan XX (2010) Functional deprivation promotes amyloid plaque pathogenesis in Tg2576 mouse olfactory bulb and piriform cortex. Eur. J. Neurosci., 31 (4): 710-721.
  17. Cai Y, Xiong K, Zhang XM, Cai H, Luo XG, Feng JC, Struble RG, Clough RW, Patrylo PR, Chu Y, Kordower JH, Yan XX (2010) β-Secretase-1 elevation in aged monkey and Alzheimer's disease human cerebral cortex occurs around vasculature in partnership with multisystem axon terminal pathogenesis and β-amyloid accumulation. Eur. J. Neurosci., 32 (7): 1223-1238.
  18. Struble RG, Ala A, Patrylo PR, Brewer GJ, Yan XX (2010) Is brain amyloid production a cause or a result of dementia of the Alzheimer type? J. Alzheimer’s Dis., 22(2): 393-399.
  19. Zhang XM, Cai Y, Cai H, Xiong K, Luo XG, Feng JC, Clough RW, Struble RG, Patrylo PR, Yan XX (2009) β-Secretase-1 elevation in transgenic mouse models of Alzheimer's disease is associated with synaptic/axonal pathology and amyloidogenesis: implications for neuritic plaque development. Eur. J. Neurosci., 30 (12): 2271-2283.
  20. Zhang XM, Cai Y, Chu Y, Chen EY, Feng JC, Luo XG, Xiong K, Clough RW, Patrylo PR, Kordower JH & Yan XX (2009) Doublecortin-expressing cells persist in the associative cerebral cortex and amygdala in aged nonhuman primates. Front. Neuroanat., 3:17.
  21. Xiong K, Luo DW, Patrylo PR, Luo XG, Struble RG, Clough RW, Yan XX (2008) Doublecortin-expressing cells are present in layer II across the adult guinea pig cerebral cortex: Partial colocalization with mature interneuron markers. Exp. Neurol., 211(1): 271-282.
  22. Yan XX, Xiong K, Luo XG, Struble RG, Clough RW (2007) β-secretase expression in normal and functionally deprived rat olfactory bulbs: Inverse correlation with oxidative metabolic activity. J. Comp. Neurol., 501(1): 52-69.
  23. Xiong K, Cai H, Luo XG, Struble RG, Clough RW, Yan XX (2007) Mitochondrial respiratory inhibition and oxidative stress elevate β-secretase (BACE1) proteins and activity in vivo in the rat retina. Exp. Brain Res., 181(3): 435-46.
  24. Xiong K, Clough RW, Luo XG, Struble RG, Li YM, Yan XX (2007) [3H]-L-685,458 as a radiotracer that maps gamma-secretase complex in the rat brain: Relevance to Abeta production and presence of active presenilin-1 components. Brain Res., 1157: 81-91.
  25. Yan XX, Li T, Rominger C, Prakash SR, Olson RE, Wong P, Zaczek R, Yu-Wen Li (2004) Binding sites of γ-secretase inhibitors in rodent brain: Distribution, postnatal development and effect of deafferentation. J. Neurosci., 24(12): 2942-2952.

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Last Updated: 2015-07-06

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