Prof. Mahvash Zakikhani

McGill University, Canada

Email: mahvash.zakikhani@mail.mcgill.ca

Qualifications

1999 Ph.D., McGill University, Parasitology

1990 M.Sc., University of Tehran, Entomology and Epidemiology

1988 B.Sc., National University, Biology

Publications (selected)

1. Mahvash Zakikhani, Miguel Bazile, Sina Hashemi, Shiva Javeshghani, Daina Avizonis, Julie St Pierre, Michael N. Pollak. (submitted). Alterations in cellular energy metabolism associatedwiththe antiproliferative effects of the ATM inhibitor KU-55933 and with metformin.
2. Carly Dool, Haider Mashhedi, Mahvash Zakikhani,Stéphanie David, Yunhua Zhao, Elena Birman, Joan M Carboni, Marco Gottardis, Marie-Jose Blouin and Michael N Pollak. 2011.
3. IGF-1/insulin receptor kinase inhibition by BMS-536924 is better tolerated than alloxan-induced hypoinsulinemia and more effective than metformin in the treatment of experimental insulin responsive breast cancer.Endocrine-Related Cancer, 18 699–709.
4. Haider Mashhedi, Marie-José Blouin, Mahvash Zakikhani, Stéphanie David, Yunhua Zhao, Miguel Bazile, Elena Birman, Carolyn Algire, Antonio Aliaga, Barry J. Bedell and Michael Pollak.2011. Metformin abolishes increased tumor 18F-2-Fluoro-2-Deoxy-D-Glucose uptake associated with a high-energy diet. Cell Cycle, 10: 2770-2778.
5. Carolyn Algire, Lilian Amrein, Miguel Bazile, Stephanie David, Mahvash Zakikhani and Michael Pollak. 2011. Diet and tumor LKB1 expression interact to determine sensitivity to anti-neoplastic effects of metformin in vivo. Oncogene. 30: 1174–1182.
6. T Inoue, M Zakikhani, S David, C Algire, MJ Blouin, M Pollak. (2010) Effects of castration on insulin levels and glucose tolerance in the mouse differ from those in man. Prostate, 70: 1628-35.
7. Carolyn Algire, Lilian Amrein, Mahvash Zakikhani, Lawrence Panasci and Michael Pollak. 2010. Metformin blocks the stimulative effect of a high energy diet on colon carcinoma growth in vivo and is associated with reduced expression of fatty acid synthase. Endocrine-Related Cancer. 17(2):351-60.
8. Zakikhani Mahvash, Blouin Marie-José, Piura Esther,Pollak Michael. 2010. Metformin and rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells. Breast Cancer Research Treatment123: 271-9.
9. Marie-José Blouin, Yunhua Zhao, Mahvash Zakikhani, Carolyn Algire, Esther Piura, Michael Pollak. 2010. Loss of function of PTEN alters the relationship between glucose concentration and cell proliferation, increases glycolysis, and sensitizes cells to 2-deoxyglucose. Cancer Letters 289(2): 246-253.
10. Avnet S, Sciacca L, Salerno M, Gancitano G, Cassarino MF, Longhi A, Zakikhani M, Carboni JM, Gottardis M,Giunti A, Pollak M, Vigneri R, Baldini N. 2009. Insulin Receptor Isoform A and Insulin-like Growth Factor II as Additional Treatment Targets n Human Osteosarcoma.Cancer Research 69 (6): 2443-2452.
11. Michael E. Cox, Martin E. Gleave, Mahvash Zakikhani, Robert H. Bell, Esther Piura, Elaine Vickers, Matthew Cunningham, Ola Larsson, Ladan Fazli, and Michael Pollak. 2009. InsulinReceptor ExpressionbyHuman Prostate 69(1): 33-40.
12. Zakikhani M, Dowling R, Sonenberg N, Pollak M. 2008. Effects of adiponectin and metformin on prostate and colon neoplasia involve activation of AMP-activated protein kinase. Cancer Prevention Research 1(5): 369-375.
13. Algire C, Zakikhani M, Blouin, MJ, Shuai JH and Pollak M. 2008. Metformin Attenuates the Stimulatory Effect of a High Energy Diet on in vivo H59 Carcinoma Growth. Endocrine-Related Cancer 15: 849-855.
14. Dowling RJ, Zakikhani M, Fantus IG, Pollak M, Sonenberg N. 2007.Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells. Cancer Research 67 (22): 10804-12.
15. Zakikhani M, Dowling R, Fantus G, Sonenberg N, Pollak M. 2006. Metformin is an AMP Kinase-dependent growth inhibitor for breast cancer cells. Cancer Research. 66 (21): 10269-10273.
16. Camirand A, Zakikhani M, Young F, Pollak M. 2005. Inhibition of insulin-like growth factor-1 receptor signaling enhances growth-inhibitory and proapoptotic effects of gefitinib (Iressa) in human breast cancer cells. Breast Cancer Research. 7(4): R570-R579.
17. Putrenko I, Zakikhani M, Dent JA. 2004. A family of acetylcholine-gated chloride channel subunits in Caenorhabditis elegans. Journal of Biological Chemistry. 280 (8): 6392-6398.
18. Zakikhani M, Smith JM, Rau ME. 2003. Effect of Plagiorchis elegans (Digenea: Plagiorchiidae) infections of Biomphalaria glabrata (Pulmonata: Planorbidae) on a challenge infection withSchistosoma mansoni (Digenea: Schistosomatidae). Journal of Parasitology 89(1): 70-75.
19. Zakikhani M, Rau ME. 1999. Plagiorchis elegans (Digenea: Plagiorchiidae) infections in Stagnicola elodes (Pulmonata: Lymnaeidae): host susceptibility, growth, reproduction, mortality and cercarial production. Journal of Parasitology. 85(3): 454-463.
20. Zakikhani M, Rau ME. 1998. Effects of Plagiorchis elegans(Digenea: Plagiorchiidae) infection on the reproduction ofBiomphalaria glabrata (Pulmonata: Planorbidae). Journal of Parasitology. 84(5): 927-930.