Dr. Tatsuya Kin

Clinical Islet Laboratory

University of Alberta/ Alberta Health Services, Canada

Technical Director

Email: tkin@ualberta.ca

Qualifications

2003 Ph.D., Nara Medical University, Japan

1992 General Surgeon certified by Japanese Surgical Society, Japan

1988 Doctor of Medicine, Nara Medical University, Japan

Publications (selected)

1. Pepper AR, Gala-Lopez B, Pawlick R, Kin T, Shapiro AMJ. A prevascularized subcutaneous ‘Device-Less’ site for islet and cellular transplantation. Nat Biotechnol 2015; 33: 518-523.
2. Tsugata T, Nikoh N, Kin T, Saitoh I, Noguchi Y, Ueki H, Watanabe M, Shapiro AMJ, Hirofumi Noguchi H. Potential factors for the differentiation of ES/iPS cells into insulin-producing cells, Cell Medicine 2015; 7: 83-93.
3. Manning Fox JE, Lyon J, Dai XQ, Wright RC, Hayward J, van de Bunt M, Kin T, Shapiro AMJ, McCarthy MI, Gloyn AL, Ungrin MD, Lakey JR, Ryan E, Kneteman NM, Warnock GL, Korbutt GS, Rajotte RV, MacDonald PE. Preservation of human islet function following twenty years of cryogenic biobanking. Diabetologia 2015; 58: 1503-1512.
4. Gill A, Dicken B, Kin T, O’Gorman D, Rosolowsky E, Senior P, Bellin MD, Shapiro AMJ, Haqq AM. Autologous islet transplantation after resection due to trauma in a toddler, CellR4 2014; 2: e1299
5. Ziff OJ, Lawrence AJ, Al-Adra DP, O’Gorman D, Kin T, Shapiro AMJ. Pediatric islet autotransplantation after hereditary pancreatitis with defined genetic variants. CellR4 2014; 2: e1197.
6. Andres A, Kin T, O’Gorman D, Bigam D, Kneteman N, Senior P, Shapiro AMJ. Impact of adverse pancreatic injury at surgical procurement upon islet isolation outcome. Transplant Int 2014; 27: 1135-1142.
7. Balamurugan AN, Naziruddin B, Lockridge A, Tiwari M, Loganathan G, Takita M, Matsumoto S, Papas K, Trieger M, Rainis H, Kin T, Kay TWH, Wease S, Messinger S, Ricordi C, Alejandro R, Markmann J, Kerr-Conti J, Rickels MR, Liu C, Zhang X, Witkowski P, Posselt A, Maffi P, Secchi A, Berney T, O’Connell PJ, Hering BJ, Barton FB. Islet product characteristics and factors related to successful human islet transplantation from the Collaborative Islet Transplant Registry (CITR) 1999-2010. Am J Transplant 2014; 14: 2595-2606.
8. Al-Adra DP, Gill RS, Imes S, O’Gorman D, Kin T, Axford SJ, Shi X, Senior PA, Shapiro AMJ. Single donor islet transplantation and long-term insulin independence in select patients with type 1 diabetes mellitus. Transplantation 2014; 98: 1007-1012.
9. Kin T, AMJ Shapiro. Horseshoe shaped pancreas. JOP. J Pancreas 2014; 15: 78.
10. Kin T, Abu-Wasel B, AMJ Shapiro. Isolated cystic duct atresia, Dig Liver Dis 2013; 46: 385-386.
11. Yamashita S, Ohashi K, Utoh R, Kin T, Shapiro AMJ, Yamamoto M, Gotoh M, Okano T. Quality of air-transported human islets for single islet cells preparations. Cell Medicine 2013; 6: 33-38.
12. Priya MM, Mohan V, Ganthimathy S, Anjana RM, Vaz SG, Thiagarajan V, Churchill TA, Kin T, Shapiro AMJ, Lakey JRT. Human islet mass, morphology, and survival after cryopreservation using the Edmonton protocol, Islets 2013; 5: 188-195.
13. O’Gorman D, Kin T, Pawlick R, Imes S, Senior P, Shapiro AMJ. Clinical islet isolation outcomes with a highly purified neutral protease for pancreas dissociation, Islets 2013; 5: 111-115.
14. Gala-Lopez BL, Semlacher E, Manoucheri N, Kin T, Shapiro AMJ. Autologous islet transplantation after total pancreatectomy for renal cell carcinoma metastases, Am J Transplant 2013, 13: 2487-2491.
15. Kolic J, Spigelman AF, Plummer G, Leung E, Hajmrle C, Kin T, Shapiro AMJ. Manning Fox JE, MacDonald PE. Distinct and opposing roles for p110α and p110β in the regulation of insulin secretion from rodent and human beta cells. Diabetologia 2013; 56: 1339-1349.
16. Manning Fox JE, Seeberger K, Dai XQ, Lyon J, Spigelman AF, Kolic J, Hajmrle C, Joseph JW, Kin T, Shapiro AMJ, Korbutt G, MacDonald PE. Functional plasticity of human infant β-cell exocytotic phenotype, Endocrinology 2013; 154: 1392-1399.
17. Gala-Lopez B, Kin T, O’Gorman D, Pepper AR, Senior P, Humar A, Shapiro AMJ. Microbial contamination of clinical islet transplant preparations is associated with very low risk of infection. Diabetes Technol Ther 2013; 15: 323-327.
18. Kin T, Korbutt GS, Shapiro AMJ., Possible link between ectopic pancreas and holoprosencephaly, Islets 2012; 4: 207-209.
19. Senior P, Kin T, Shapiro AMJ, Koh A. Islet transplantation at the University of Alberta: status update and review of progress over the last decade. Can J Diabetes 2012; 36: 32-37.
20. McCall M, Maciver AM, Kin T, Emamaullee J, Pawlick R, Edgar R, Shapiro AMJ. The caspase inhibitor IDN6556 facilitates marginal mass islet engraftment in a porcine islet autotransplant model. Transplantation 2012; 94: 30-35.
21. Dai XQ, Manning Fox JE, Chikvashvili D, Casimir M, Plummer G, Hajmrle C, Spigelman AF, Kin T, Singer-Lahat D, Kang Y, Shapiro AMJ, Gaisano HY, Lotan I, MacDonald PE. The Kv2.1 channel regulates insulin secretion from rodent and human islets independent of its electrical function. Diabetologia 2012; 55: 1709-1720.
22. McCall M, Pawlick R, Kin T, Shapiro AM. Anakinra potentiates the protective effects of etanercept in transplantation of marginal mass human islets in immunodeficient mice. Am J Transplant 2012; 12: 322-329.
23. Westermark GT, Davalli AM, Secchi A, Folli F, Kin T, Toso C, Shapiro AMJ, Korsgren O, Tufveson G, Andersson A, Westermark P. Further evidence for amyloid deposition in clinical pancreatic islet grafts. Transplantation 2012; 93: 219-223.
24. Kawahara T, Kin T, Shapiro AMJ. A comparison of islet autotransplantation and allotransplantation and factors elevating acute portal pressure in clinical islet transplantation. J Hepatobiliary Pancreat Sci 2012; 19: 282-288.
25. Merani S, McCall MD, Pawlick RL, Edgar RL, Davis J, Toso C, Emamaullee JA, Kin T, Shapiro AMJ. AEB-071 (sotrastaurin) does not exhibit toxic effects on human islets nor transplantation into immunodeficient mice. Islets 2011; 3: 338-343.