Prof. Hai Yan Zhang

Chinese Academy of Sciences





2003 Ph.D., Chinese Academy of Sciences

1998 B.S., Hangzhou University

Publications (selected)

  1. Wang Y, Tang XC, Zhang HY*. Huperzine A alleviates synaptic deficits and modulates amyloidogenic and nonamyloidogenic pathways in APPswe/PS1dE9 transgenic mice. J Neurosci Res. 2012; 90: 508-17.
  2. Jiang CS, Guo XJ, Gong JX, Zhu TT, Zhang HY*, Guo YW. Synthesis and biological evaluation of 21-arylidenepregnenolone derivatives as neuroprotective agents. Bioorg Med Chem Lett. 2012; 22: 2226-2229.
  3. Wang Y, Yang YS, Tang XC, Zhang HY*. T33, a novel peroxisome proliferator-activated receptor γ/α agonist, exerts neuroprotective action via its anti-inflammatory activities. Acta Pharmacol Sin. 2011 Sep; 32 (9): 1100-8.
  4. Wang Y, Huang LQ, Tang XC, Zhang HY*. Retrospect and prospect of active principles from Chinese herbs in the treatment of dementia. Acta Pharmacol Sin. 2010; 31: 649-64.
  5. Wang J, Zhang HY*, Tang XC. Huperzine A improves chronic inflammation and cognitive decline in rats with cerebral hypoperfusion. J Neurosci Res. 2010; 88: 807-15.
  6. Gao X, Zheng CY, Tang XC, Zhang HY*. Huperzine A Protects Isolated Rat Brain Mitochondria against β-Amyloid Peptide. Free Radical Biol & Med2009; 46: 1454-62.
  7. Wang J, Zhang HY, Tang XC.Cholinergic deficiency involved in vascular dementia: relevant therapeutic strategy and possible anti-inflammatory mechanisms. Acta Pharmacol Sin. 2009; 30: 879-88.
  8. Zhu YP, Xiao K, Ma LP, Xiong B, Fu Y, Yu HP, Wang W, Wang X, Hu DY, Peng HL, Li JY, Gong Q, Chai Q, Tang XC, Zhang HY*, Li J, Shen JK. Design, synthesis and biological evaluation of novel dual inhibitors of acetylcholinesterase and b-secretase. Bioorgan Med Chem. 2009; 17: 1600-13.
  9. Shi YF, Zhang HY*, Wang W, Fu Y, Xia Y, Tang XC, Bai DL, He XC. Novel 16-substituted bifunctional derivatives of huperzine B: multifunctional cholinesterase inhibitors. Acta Pharmacol Sin. 2009; 30: 1195-203.
  10. Wang ZF, Wang J, Zhang HY*, Tang XC.Huperzine A exhibits anti-inflammatory and neuroprotective effects in a rat model of transient focal cerebral ischemia. J Neurochem. 2008; 106: 1594-603.
  11. Zheng CY, Zhang HY*, Tang XC. Huperzine A attenuates mitochondrial dysfunction after middle cerebral artery occlusion in rats. J Neurosci Res. 2008; 86: 2432-40.
  12. Zhang HY, Zheng CY, Yan H, Wang ZF, Tang LL, Gao X, Tang XC. Potential therapeutic targets of huperzine A for Alzheimer's disease and vascular dementia. Chem Biol Interact. 2008; 175: 396-402.
  13. Zhang HY, Yan H, Tang XC. Non-cholinergic effects of huperzine A: beyond inhibition of acetylcholinesterase. Cell Mol Neurobiol. 2008; 28: 173-83.
  14. Zhang HY, Tang XC. Studies of natural products on treating neurological disorders in china. Cell Mol Neurobiol. 2008; 28: 9-12.
  15. Zhuo JM, Prescott SL, Murray ME, Zhang HY, Early discrimination reversal learning impairment and preserved spatial learning in a longitudinal study of Tg2576 APPsw mice. Neurobiol Aging. 2007; 28: 1248-57.
  16. Zhuo JM, Prakasam A, Murray ME, Zhang HY, Baxter MG, Sambamurti K, Nicolle MM. An Increase in Abeta42 in the Prefrontal Cortex is Associated with a Reversal-Learning Impairment in Alzheimer's Disease Model Tg2576 APPsw Mice. Curr Alzheimer Res. 2008; 5: 385-91.
  17. Zhou ZW, Yin S, Zhang HY, Fu Y, Yang SP, Wang XN, Wu Y, Tang XC, Yue JM. Walsucochins A and B with an unprecedented skeleton isolated from Walsura cochinchinensis. Org Lett. 2008; 10: 465-8.
  18. Zhang HY, Watson ML, Gallagher M, Nicolle MM. Muscarinic receptor-mediated GTP-Eu binding in the hippocampus and prefrontal cortex is correlated with spatial memory impairment in aged rats. Neurobiol Aging. 2007; 28: 619-26.
  19. Zhang HY, Tang XC. Neuroprotective effects of huperzine A: new therapeutic targets for neurodegenerative disease.Trends Pharmacol Sci. 2006; 27: 619-25.
  20. Yan H, Zhang HY, Tang XC. Involvement of M1-muscarinic acetylcholine receptors, protein kinase C and mitogen-activated protein kinase in the effect of huperzine A on secretory amyloid precursor protein-alpha. Neuroreport.2007; 18: 689-92.
  21. Zhang HY, Yan H, Tang XC. Huperzine A enhances the level of secretory amyloid precursor protein and protein kinase C-alpha in intracerebroventricular beta-amyloid-(1-40) infused rats and human embryonic kidney 293 Swedish mutant cells. Neurosci Lett. 2004; 360: 21-4.
  22. Zhang HY, Brimijoin S, Tang XC. Apoptosis induced by beta-amyloid25-35 in acetylcholinesterase-overexpressing neuroblastoma cells. Acta Pharmacol Sin. 2003; 24: 853-8.
  23. Zhang HY, Tang XC. Huperzine A attenuates the neurotoxic effect of staurosporine in primary rat cortical neurons. Neurosci Lett. 2003; 340: 91-4.
  24. Zhang HY, Liang YQ, Tang XC, He XC, Bai DL. Stereoselectivities of enantiomers of huperzine A in protection against beta-amyloid(25-35)-induced injury in PC12 and NG108-15 cells and cholinesterase inhibition in mice. Neurosci Lett. 2002; 317: 143-6.

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