Prof. Yves Mély

Faculty of Pharmacy

Louis Pasteur University, France

Professor

Email: yves.mely@unistra.fr

Qualifications

2011 Honorary Doctor, University of Kiev

1993-2009 Research and doctoral directory bonus

Publications (Selected)

1. V.J. GREINER, C. EGELE, S. ONCUL, F. RONZON, C. MANIN, A. KLYMCHENKO, & Y. MELY. Characterization of the lipid and protein organization in HBsAg viral particles by steady-state and time resolved fluorescence spectroscopy. Biochimie, 2010, 92, 994-1002. IF=3.5.
2. C. BOUDIER, R. STORCHAK, P. DIDIER, A. FOLLENIUS-WUND, S. MULLER, J.-L. DARLIX and Y. MELY. Investigating the annealing activity of the HIV-1 trans-activator of transcription TAT. J. Mol. Biol., 2010, 400, 487-501. IF = 4.3.
3. J.V. FRITZ, L. BRIANT, Y. MELY, S. BOUAZIZ, & H. de ROCQUIGNY. HIV-1 Viral Protein R : from structure to function. Future Virology. 2010, 5, 607-625. IF=0.7.
4. K. AMARI, E. BOUTANT, C. HOFMANN, C. SCHMITT-KEICHINGER, L. FERNANDEZ-CALVINO, P. DIDIER, A. LERICH, J. MUTTERER, C. THOMAS, Y. MELY, A. MAULE, & C. RITZENTHALER. Plasmodesmal proteins with receptor-like properties for plant viral movement proteins. Plos Pathogens. 2010., 6, e1001119 (10 pages) IF = 9.7. Cited in the Faculty of 1000 Biology.
5. J. GODET, & Y. MELY. Biophysical studies of the nucleic acid chaperone properties of the HIV-1 nucleocapsid protein. RNA Biology, 2010, 7, 48-60. IF=5.6.
6. V. Y. POSTUPALENKO, V. V. SHVADCHAK, G. DUPORTAIL, V. G. PIVOVARENKO, A. S. KLYMCHENKO, & Y. MELY. Monitoring membrane binding and insertion of peptides by two-color fluorescent label. Biochim Biophys Acta- Biomembranes, 2011, 1808, 424-32. IF = 4.4.
7. N. JAIN, Y. ARNTZ, V. GOLDSCHMIDT, G. DUPORTAIL, Y. MELY, & A.S. KLYMCHENKO. New unsymmetrical bolaamphiphiles: synthesis, assembly with DNA and application for gene delivery. Bioconjug Chem. 2010, 21, 2110-2118. IF=4.8.
8. A. PERRINO, A. KLYMCHENKO, A. MORERE, E CONTAL, A RAMEAU, J.M. GUENET, Y MELY, & A. WAGNER. Insight into the structure and behaviour of polydiacetylene-based micelles. Macromol. Chem. Phys., 2010, 212, 111-117. IF=2.6.
9. Y. SATO, N. RAMALANJAONA, T. HUET, N. POTIER, J. OSZ, P. ANTONY, C. PELUSO-ILTIS, P. POUSSIN-COURMONTAGNE, E. ENNIFAR, Y. MELY, A. DEJAEGERE, D. MORAS, & N. ROCHEL. The “Phantom Effect” of the Rexinoid LG100754: Structural and Functional Insights. PLoS ONE 2010, 5, e15119.
10. S. LECAT, M. OUEDRAOGO, T. CHERRIER, F. NOULET, P. RONDE, N. GLASSER, J.L. GALZI, Y. MELY, K. TAKEDA, & B. BUCHER. Contribution of a tyrosine-based motif to cellular trafficking of wild type and truncated NPY Y1 receptors. Cell Signal. 2011, 23, 228-238. IF=4.1.
11. A. BAZZI, L. ZARGARIAN, F. CHAMINADE, C. BOUDIER, H. de ROCQUIGNY, B. RENE, Y. MELY, P. FOSSE, & O. MAUFFRET. Structural insights into the cTAR DNA recognition by the HIV-1 Nucleocapsid protein: role of sugar deoxyriboses in the binding polarity of NC. Nucleic Acids Res, 2011, 39, 3903-3916. IF=7.5.
12. O. ZAMOTAIEV, V. POSTUPALENKO, V. SHVADCHAK, V. PIVOVARENKO, A. KLYMCHENKO, & Y. MELY. Improved hydration-sensitive dual-fluorescence labels for monitoring peptide-DNA interactions. Bioconjug. Chem. 2011, 22, 101-107. IF=4.8.
13. E. CONTAL, A. KLYMCHENKO, Y. MELY, S. MEUNIER, & A. WAGNER. Core functionalization of polydiacetylene micelles by « click » reaction. Soft matter, 2011, 7, 1648-1650. IF=5.4
14. N. ROCHEL, F. CIESIELSKI, J. GODET, E. MOMAN, M. ROESSLE, C. PELUSO-ILTIS, Y. MELY, D. I. SVERGUN, & D. MORAS. Solution structures of 3 nuclear receptors heterodimers RXR/RAR, RXR/VDR and RXR/PPAR on DNA. Nat. Struct. Mol. Biol. 2011, 18, 564-570. IF=12.3.
15. R. V. RODIK, A.S. KLYMCHENKO, N. JAIN, S.I. MIROSHNICHENKO, L. RICHERT, V.I. KALCHENKO, & Y. MELY. Virus-sized DNA nanoparticles for gene delivery based on micelles of cationic calixarenes. Chemistry- A European Journal. 2011, 17, 5526-5538. IF =5.56.
16. B. GRIGOROV, A. BOCQUIN, C. GABUS, S. AVILOV, Y. MELY, A. AGOPIAN, G. DIVITA, M. GOTTIKH, M. WITVROUW, & J.L. DARLIX. Identification of a methylated oligoribonucleotide as a potent inhibitor of HIV-1 reverse transcription. Nucleic Acids Res., 2011, 39, 5586-96. IF=7.5.
17. J.L. DARLIX, J. GODET, R. IVANYI-NAGY, P. FOSSE, O. MAUFFRET, & Y. MELY. Flexible nature and specific functions of the HIV-1 Nucleocapsid protein. J. Mol. Biol. 2011, 410, 565-81. IF=4.3
18. J. GODET, N. RAMALANJAONA, K.K. SHARMA, L. RICHERT, H. de ROCQUIGNY, J.L. DARLIX, G. DUPORTAIL, & Y. MELY. Specific implications of the HIV-1 nucleocapsid zinc fingers in the annealing of the Primer Binding Site complementary sequences during the obligatory plus strand transfer. Nucleic Acids Res., 2011, 39, 6633-6645. IF=7.5.
19. V. GREINER, V. SHVADCHAK, Y. ARNTZ, J FRITZ, P. DIDIER, B. FRISCH, C. BOUDIER, Y. MELY, & H. DE ROCQUIGNY. Characterization of the mechanisms of Vpr(52-96) internalization in cells. Biochimie, 2011, 93, 1647-58. IF=3.2. Adrerus thesis prize in 1990.