Email: olli.pentikainen@jyu.fi

Qualifications

2003 Ph.D., Biochemistry, Åbo Akademi University, Finland

Publications (Selected)

1. Koivunen JT, Nissinen L, Käpylä J, Jokinen J, Pihlavisto M, Marjamäki A, Heino J, Huuskonen J, Pentikäinen OT. Fluorescent small molecule probe to modulate and explore alpha2beta1 integrin function. Journal of the American Chemical Society, 133, 14558-14561.
2. Koivunen JT, Nissinen L, Juhakoski A, Pihlavisto M, Marjamäki A, Huuskonen J, Pentikäinen OT. Blockage of Collagen Binding to Integrin alpha2beta1: Structure-activity Relationship of Protein-protein Interaction Inhibitors, Medicinal Chemistry Communications, 2, 764-770.
3. Niinivehmas SP, Virtanen SI, Lehtonen JV, Postila PA, Pentikäinen OT. Comparison of Virtual High-throughput Screening Methods for the Identification of Phosphodiesterase-5 Inhibitors, Journal of Chemical Information and Modeling, 51:1353-1363.
4. Postila PA, Ylilauri M, Pentikäinen OT. Full and Partial Agonism of Ionotropic Glutamate Receptors.
5. Indicated by Molecular Dynamics Simulations, Journal of Chemical Information and Modeling, 2011, 51:1037–1047.
6. Nurminen EM, Pihlavisto M, Lázár L, Pentikäinen U, Fülöp F, Pentikäinen OT. Novel hydrazine molecules as tools to understand the flexibility of vascular adhesion protein-1 ligand-binding site towards more selective inhibitors, Journal of Medicinal Chemistry, 2011, 54: 2143–2154.
7. Nurminen EM, Pihlavisto M, Lazar L, Szakonyi Z, Pentikäinen, U, Fulop, F, Pentikäinen, OT. Synthesis, in vitro activity, and three-dimensional quantitative structure-activity relationship of novel hydrazine inhibitors of human Vascular Adhesion Protein-1, Journal of Medicinal Chemistry, 2010, 53: 6301–6315.
8. Virtanen SI, Pentikäinen OT. Efficient Virtual Screening Using Multiple Protein Conformations Described as Negative Images of the Ligand-Binding Site. Journal of Chemical Information and Modeling, 2010, 50: 1005–1011.
9. Postila P, Swanson GT, Pentikäinen OT. Exploring kainate receptor pharmacology using molecular dynamics simulations. Neuropharmacology, 2010, 58: 515-527.
10. Nissinen L, Pentikäinen OT, Jouppila A, Käpylä J, Ojala M, Nieminen J, Lipsanen A, Lappalainen H, Eckes B, Johnson MS, Lassila R, Marjamäki A, Heino J. A small molecule inhibitor of integrin alpha2beta1 introduces a new strategy for antithrombotic therapy. Thrombosis and Haemostasis, 103: 387-397.