Prof. Deepak Bastia
Department of Biochemistry and Molecular Biology
Medical University of South Carolina, USA
Email: bastia@musc.edu
Qualifications
1971 Ph.D., Biology, University of Chicago
1963 B.Sc., Biology, Mathematics and Chemistry, Utkal University
Publications (Selected)
-
Gautam, A. and Bastia, D. 2001. A replication terminus located at or near a replication checkpoint of Bacillus subtilis functions independently of stringent control. J. Biol. Chem. 276:8771-8777.
-
Mohanty, B.K., Bussiere, D.E., Sahoo, T., Pai, K.S., Meijer, W.J., Bron, S. and Bastia, D. 2001. Structural and functional analysis of a bipolar replication terminus. Implications for the origin of polarity of fork arrest. J. Biol. Chem. 276:13160-13168.
-
Guatam, A., Mulugu, S., Alexander, K. and Bastia, D. 2001. A single domain of the replication termination protein of Bacillus subtilis is involved in arresting both DnaB helicase and RNA polymerase. J. Biol. Chem. 276:23471-23479.
-
Mulugu, S., Potnis, A., Shamsuzzaman, Taylor, J., Alexander, K. and Bastia, D. 2001. Mechanism of termination of DNA replication of Escherichia coli involves helicase-contrahelicase interaction. Proc. Natl. Acad. Sci. USA 98:9569-9574.
-
Sharma, R., Kachroo, A. and Bastia, D. 2001. Mechanistic aspects of DnaA-RepA interaction as revealed by yeast forward and reverse two-hybrid analysis. EMBO J. 20:4577-4587.
-
Abhyankar, M. M, Reddy, J. M., Sharma, R., Bullesbach, E. and Bastia, D. (2004) Biochemical investigations of control of replication initiation of plasmid R6K. J. Biol. Chem. 279: 6711-6719.
-
Zzaman, S., Abhyankar, M. M. and Bastia, D. (2004) Reconstitution of F factor replication in vitro with purified proteins. J. Biol. Chem. 279: 17404-17410.
-
Mohanty, B. K. and Bastia, D. (2004) Binding of the replication terminator protein Fob1p to the Ter sites of yeast causes polar fork arrest. J. Biol. Chem. 279: 1932-1941.
-
Zzaman, S., Reddy, J. M. and Bastia, D. (2004) The DnaK-DnaJ-GrpE chaperone system activates inert wild type Pi initiator protein of R6K into a form active in replication. J. Biol. Chem. 279, 50886-50894.
-
Zzaman, S. and Bastia, D. (2005) Oligomeric Initiator protein-mediated DNA looping negatively regulates plasmid replication in vitro by preventing origin melting Mol. Cell 20, 833-843.
-
Bastia, D. (2005) Mechanism of initiation and termination of plasmid DNA replication in prokaryotes. Curr. Sci. 89: 329-334
-
Bastia, D. and Mohanty, B. K. (2006). Termination of DNA Replication, In DNA replication and human disease (ed. M.L. DePamphilis), pp. 155-174. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.
-
Krings, G. and Bastia, D. (2005) Sap1p binds to Ter1 at the ribosomal DNA of Schizosaccharomyces pombeand causes polar replication fork arrest. J. Biol. Chem. 280:39135-39142.
-
Mohanty, B. K., Bairwa, N. and Bastia, D. (2006) The Tof1p-Csm3p protein complex counteracts the Rrm3p hellicase to control replication termination of Saccharomyces cerevisiae. Proc. Nat. Acad. SciUSA103, 897-902.
-
Swan, M., Bastia, D. and Davies, C. (2006) Crystalstructure of the Pi-iteron complex of plasmid R6K: Implications for initiation of replication Proc. Natl. Acad. Sci. USA 103: 18481- 18486.
-
Krings, G. and Bastia, D.(2006) Molecular architecture of a eukaryotic DNA replication terminus-terminator protein complex. Mol. Cell. Biol. 26, 8061-8074.
-
Bastia, D., Zzaman, S., Krings, G., Saxena, M, Peng, X. and Greenberg, M.M. (2008) Mechanism of replication termination as revealed by Tus-mediated polar arrest of a sliding helicase. Proc. Natl. Acad. SciUSA105, 12831-12836.
-
Biswas, S. and Bastia, D. (2008) Mechanistic insights into termination of DNA replication obtained from Reb1p-Ter3 interaction inS. pombe. Mol. Cell. Biol. 28: 6844-6857.
-
Mohanty, B.K., Bairwa, N. K. and Bastia, D. (2009) Contrasting roles of checkpoint proteins as recombination modulators at Fob1-Ter complexes with or without fork arrest. Eucaryot. Cell 8: 487-495.
-
Kaplan, D. and Bastia, D. (2009) Mechanism of polar arrest of replication forks. Mol. Microbiol. 72; 279-285.
-
Saxena, M., Singh, S., Zzaman, S. and Bastia, D. (2010) Investigations of Pi initiator protein-mediated interactions between Replication origins and of the plasmid R6K. J. Biol. Chem 285: 5695-5694.
-
Saxena, M., Abhayankar, M., and Bastia, D. (2010) Replication initiation at a distance: determination of the cis and trans-acting elements of replication origin. J. Biol. Chem. 285:5705-5712.
-
Bairwa, N., Zzaman, S. Mohanty, B.K. and Bastia, D. (2010). Replication fork arrest and rDNA silencing are 2 independent and separable functions of the replication terminator protein Fob1 of S. cerevisiae. J. Biol. Chem. 285: 12612-12619.
-
Singh, S., Sabatinos, S., Forsburg, S. and Bastia, D. (2010) Regulation of replication termination in Schizosccharomyces pombe by Reb1 protein-mediated action at a distance. Cell 142, 868-878.
-
Bairwa, N.K., Mohanty, B. K. and Bastia, D. (2011) The intra-S phase checkpoint protein Tof1 collaborates with the helicase Rrm3 and the F-box protein Dia2 to maintain genome stability in Saccharomyces cerevisiae. J. Biol. Chem. 286: 2445-2554.
-
Bastia, D. and Singh, S. (2011) Chromosome kissing and modulation of replication termination. BioArchitecture. 1: 24-28.