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Dr. Lisa B. Signorello
International Epidemiology Institute, USA
E-mail: Lisa.Signorello@intepi.org
1998 D.Sc., Harvard University, School of Public Health (Epidemiology)
1996 M.Sc., Harvard University, School of Public Health (Epidemiology)
1990 B.S., University of Pennsylvania (Engineering)
Publications (Selected) 
  1. Garidou A, Tzonou A, Lipworth L, Signorello LB, Kalapothaki V, Trichopoulos D. Lifestyle factors and medical conditions in relation to esophageal cancer by histologic type in a low-risk population. Int J Cancer 1996;68:295-9.
  2. Tzonou A, Lipworth L, Garidou A, Signorello LB, Lagiou P, Hsieh C-c, Trichopoulos D. Diet and risk of esophageal cancer by histologic type in a low-risk population. Int J Cancer 1996;68:300-4.
  3. Signorello LB, Harlow BL, Cramer DW, Spiegelman D, Hill JA. Epidemiologic determinants of endometriosis: A hospital-based case-control study. Ann Epidemiol 1997;7:267-74.
  4. Katsouyanni K, Signorello LB, Lagiou P, Egan K, Trichopoulos D. Evidence that adult life risk factors influence the expression of familial propensity to breast cancer. Epidemiol 1997;8:592-5.
  5. Signorello LB, Tzonou A, Mantzoros CS, Lipworth L, Lagiou P, Hsieh C-c, Stampfer M, Trichopoulos D. Serum steroids in relation to prostate cancer risk in a case-control study (Greece). Cancer Causes Control 1997;8:632-6.
  6. Seretakis D, Lagiou P, Lipworth L, Signorello LB, Rothman K, Trichopoulos D. Changing seasonality of mortality from coronary heart disease. JAMA 1997;278:1012-4.
  7. Mantzoros CS, Tzonou A, Signorello LB, Stampfer M, Trichopoulos D, Adami H-O. Insulin-like growth factor 1 in relation to prostate cancer and benign prostatic hyperplasia. Brit J Cancer 1997;76:1115-8.
  8. Lagiou P, Mantzoros CS, Tzonou A, Signorello LB, Lipworth L, Trichopoulos D. Serum steroids in relation to benign prostatic hyperplasia. Oncology 1997;54:497-501.
  9. Lagiou P, Signorello LB, Trichopoulos D, Tzonou A, Trichopoulou A, Mantzoros CS. Leptin in relation to prostate cancer and benign prostatic hyperplasia. Int J Cancer 1998;76:25-8.
  10. Wolk AM, Mantzoros CS, Andersson S-O, Signorello LB, Lagiou P, Bergstrom R, Trichopoulos D, Adami H-O. Insulin-like growth factor 1 in relation to prostate cancer - A population-based case-control study in Sweden. J Nat Cancer Inst 1998;90:911-5.
  11. Hsieh C-c, Signorello LB, Lipworth L, Lagiou P, Mantzoros CS, Trichopoulos D. Predictors of sex hormone levels among the elderly. A study in Greece. J Clin Epidemiol 1998;51:837-41.
  12. Mirhashemi R, Harlow BL, Ginsburg ES, Signorello LB, Berkowitz R, Feldman S. Predicting risk of complications after gynecological laparoscopic surgery. Obstet Gynecol 1998;92:327-31.
  13. Signorello LB, Harlow BL, Wang S, Erick M. Saturated fat intake and the risk of severe hyperemesis gravidarum. Epidemiol 1998;9:636-40.
  14. Mantzoros CS, Signorello LB, Trichopoulos D. Insulin-like growth factor 1 in relation to prostate cancer and benign prostatic hyperplasia – reply. (Letter) Br J Cancer 1998;78:555-6.
  15. Harlow BL, Signorello LB, Hall JE, Dailey C, Komaroff AL. Reproductive correlates and risk of chronic fatigue syndrome. Am J Med 1998;105:94S-99S.
  16. Signorello LB, Trichopoulos D. Perinatal determinants of adult cardiovascular disease and cancer. (Editorial) Scand J Soc Med 1998;26:161-5.
  17. Trichopoulos D, Signorello LB, Adami H-O. Towards a coherent model for breast cancer etiology. (Review) Sem Cancer Biol 1998;8:255-62.
  18. Signorello LB, Wuu J, Hsieh C-c, Tzonou A, Trichopoulos D, Mantzoros CS. Hormones and hair patterning in men: a role for insulin-like growth factor 1? J Am Acad Dermatol 1999;40:200-3.
  19. Tzonou A, Signorello LB, Lagiou P, Wuu J, Trichopoulos D, Trichopoulou A. Diet and cancer of the prostate: a case-control study in Greece. Int J Cancer 1999;80:704-8.
  20. Ekstrom AM, Signorello LB, Hansson L-E, Bergstrom R, Lindgren A, Nyren O. Evaluating gastric cancer misclassification: a potential explanation for the rise in cardia cancer incidence. J Nat Cancer Inst 1999;91:786-90.
  21. Lagiou P, Signorello LB, Mantzoros CS, Trichopoulous D, Hsieh C-c, Trichopoulou A. Hormonal, lifestyle, and dietary factors in relation to leptin among elderly men. Ann Nut Metab 1999;43:23-9.
  22. Pinto AP, Signorello LB, Crum CP, Harlow BL, Abrao F, Villa LL. Squamous cell carcinoma of the vulva in Brazil: prognostic importance of host and viral variables. Gynecol Oncol 1999;74:61-7.
  23. Signorello LB, Tzonou A, Lagiou P, Samoli E, Zavitsanos X, Trichopoulos D. The epidemiology of benign prostatic hyperplasia: A study in Greece. Br J Urol 1999;84:286-91.
  24. Signorello LB, Brismar K, Bergstrom R, Andersson SO, Wolk A, Trichopoulos D, Adami HO. Insulin-like growth factor binding protein-1 and prostate cancer. J Natl Cancer Inst 1999;91:1965-7.
  25. Ekstrom AM, Eriksson M, Hansson LE, Lindgren A, Signorello LB, Nyren O, Hardell L. Occupational exposures and risk of gastric cancer in a population-based case-control study. Cancer Res 1999;59:5932-7.
  26. Signorello LB, Harlow BL, Chekos AK, Repke JT. Midline episiotomy and anal incontinence: retrospective cohort study. BMJ 2000;320:86-90.
  27. Ekstrom AM, Hansson L-E, Signorello LB, Lindgren A, Bergstrom R, Nyren O. Decreasing incidence of both major histologic subtypes of gastric adenocarcinoma: A population-based study in Sweden. Br J Cancer 2000;83:391-6.
  28. Signorello LB, Kuper HE, Lagiou P, Wuu J, Mucci LA, Trichopoulos D, Adami H-O. Lifestyle factors and insulin-like growth factor 1 levels among elderly men. Eur J Cancer Prev 2000;9:173-8.
  29. Fryzek JP, Weiderpass E, Signorello LB, Hakelius L, Lipworth L, Blot WJ, McLaughlin JK, Nyren O. Characteristics of women with cosmetic breast augmentation surgery compared with breast reduction surgery patients and women in the general population of Sweden. Ann Plastic Surg 2000;45:349-56.
  30. Moradi T, Weiderpass E, Signorello LB, Persson I, Nyrén O, Adami HO. Physical activity and postmenopausal endometrial cancer risk (Sweden). Cancer Causes Control 2000;11:829-37.
  31. Harlow BL, Signorello LB. Factors associated with early menopause. (Review) Maturitas 2000;35:3-9.
  32. Akre K, Signorello LB, Engstrand L, Bergstrom R, Larsson S, Eriksson B, Nyren O. Risk for gastric cancer after antibiotic prophylaxis in patients undergoing hip replacement. Cancer Res 2000;60:6376-80.
  33. Cnattingius S, Signorello LB, Anneren G, Clausson B, Ekbom A, Ljunger E, Blot WJ, McLaughlin JK, Peterson G, Rane A, Granath F. Caffeine intake and the risk of first trimester spontaneous abortion. New Engl J Med 2000;343:1839-45.
  34. Fryzek JP, Signorello LB, Hakelius L, Feltelius N, Ringberg A, Blot WJ, McLaughlin JK, Nyren O. Self-reported symptoms among women after cosmetic breast implant and breast reduction surgery. Plast Reconstruc Surg 2001;107:206-13.
  35. Fryzek JP, Signorello LB, Hakelius L, Lipworth L, McLaughlin JK, Blot WJ, Nyren O. Local complications and subsequent symptom reporting among women with cosmetic breast implants. Plast Reconstruc Surg 2001;107:214-21.
  36. Signorello LB, Blot WJ, McLaughlin JK, Fryzek JP, Nyren O. Offspring health risk after cosmetic breast implantation in Sweden. Ann Plastic Surg 2001;46:279-86.
  37. Akre K, Ekstrom AM, Signorello LB, Hansson L-E, Nyren O. Aspirin and risk for gastric cancer: A population-based case-control study in Sweden. Br J Cancer 2001;84:965-8.
  38. Signorello LB, Kennedy JA, Richmond R, Sieu K, Blot WJ, Harrison DC. Self-reported quality of life and health among Bjork-Shiley convexo-concave prosthetic heart valve patients. J Heart Valve Dis 2001;10:210-8.
  39. Signorello LB, Harlow BL, Chekos AK, Repke JT. Postpartum sexual functioning and its relationship to perineal trauma: A retrospective cohort study of primiparas. Am J Obstet Gynecol 2001;184:881-90.
  40. Signorello LB, Ye W, Fryzek JP, Lipworth L, Fraumeni JF Jr, Blot WJ, McLaughlin JK, Nyrén O. Nationwide study of cancer risk among hip replacement patients in Sweden. J Natl Cancer Inst 2001;93:1405-10.
  41. Signorello LB, Nordmark A, Granath F, Blot WJ, McLaughlin JK, AnnerénG,Lundgren S, Ekbom A, Rane A, Cnattingius S. Caffeine metabolism and the risk of spontaneous abortion of normal karyotype fetuses. Obstet Gynecol 2001;98:1059-66.
  42. Fored CM, Ejerblad E, Lindblad P, Fryzek JP, Dickman PW, Signorello LB, Lipworth L, Elinder C-G, Blot WJ, McLaughlin JK, Zack MM, Nyrén O. Acetaminophen, aspirin, and chronic renal failure: A nationwide case-control study in Sweden. New Engl J Med 2001;345:1801-8.
  43. Kjoller K, Friis S, Signorello LB, McLaughlin JK, Blot WJ, Lipworth L, Mellemkjaer L, Winther JF, Olsen JH. Health outcomes in offspring of Danish mothers with cosmetic breast implants. Ann Plast Surg 2002;48:238-45.
  44. Clausson B, Granath F, Ekbom A, Lundgren S, Nordmark A, Signorello LB, Cnattingius S. Effect of caffeine exposure during pregnancy on birthweight and gestational age. Am J Epidemiol 2002;155:429-36.
  45. Fryzek JP, Lipworth L, Signorello LB, McLaughlin JK. The reliability of dietary data for self and next-of-kin respondents. Ann Epidemiol 2002;12:278-83.
  46. Fryzek JP, Ye W, Signorello LB, Lipworth L, Blot WJ, McLaughlin JK, Nyrén O. Incidence of cancer among patients with knee implants in Sweden, 1980-1994. Cancer 2002;94:3057-62.
  47. Signorello LB, McLaughlin JK, Lipworth L, Friis S, Sorensen HT, Blot WJ. Confounding by indication in epidemiologic studies of commonly used analgesics. (Review) Am J Ther 2002;9:199-205.
  48. Signorello LB, Ye W, Fryzek JP, Blot WJ, Lipworth L, McLaughlin JK, Nyrén O. A nationwide follow-up study of autoimmune and connective tissue disease among hip and knee implant patients. J Long Term Eff Med Implants 2002;12:255-62.
  49. Lipworth L, Friis S, Mellemkjaer L, Signorello LB, Johnsen SP, Nielsen GL, McLaughlin JK, Blot WJ, Olsen JH. A population-based cohort study of mortality among adults prescribed paracetamol in Denmark. J Clin Epidemiol 2003;56:796-801.
  50. Signorello LB, McLaughlin JK, Lipworth L, Friis S, Sorensen HT, Blot WJ. Confounding by indication: implications for implant research. (Review) J Long Term Eff Med Implants 2003;13:63-8.
  51. Buchowski MS, Schlundt DG, Hargreaves MK, Hankin JH, Signorello LB, Blot WJ. Development of a culturally sensitive food frequency questionnaire for use in the Southern Community Cohort Study. Cell Mol Biol 2003;49:1295-304.
  52. Signorello LB, McLaughlin JK. Maternal caffeine consumption and spontaneous abortion: A review of the epidemiologic evidence (Review) Epidemiology 2004;15:229-39.
  53. Signorello LB, Hargreaves MK, Steinwandel MD, Zheng W, Cai Q, Schlundt DG, Buchowski MS, Arnold CW, McLaughlin JK, Blot WJ. Southern Community Cohort Study: Establishing a cohort to investigate health disparities. J Natl Med Assoc 2005;97:972-9.
  54. Fowke JH, Schlundt D, Signorello LB, Ukoli FAM, Blot WJ. Prostate cancer screening between among low-income African-American and Caucasian men. Urol Oncol 2005;23:333-40.
  55. McLaughlin JK, Signorello LB, Lipworth L. Bias in epidemiologic studies of analgesics and disease. Family Practice Recertification 2005;27:23-9.
  56. Fowke JH, Signorello LB, Underwood W, Ukoli FAM, Blow WJ. Obesity and prostate cancer screening among African-American and Caucasian men. Prostate 2006;66:1371-80.
  57. Fowke JH, Signorello LB, Chang SS, Matthews CE, Buchowski, MS, Cookson MS, Ukoli FM, Blot WJ. Effects of obesity and height on prostate-specific antigen (PSA) and percentage of free PSA levels among African-American and Caucasian men. Cancer 2006;107:2361-7.
  58. Signorello LB, Cohen SS, Bosetti C, Stovall M, Kasper CE, Weathers RE, Whitton JA, Green DM, Donaldson SS, Mertens AC, Robison LL, Boice JD, Jr. Female survivors of childhood cancer: preterm birth and low birth weight among their children. J Natl Cancer Inst 2006;98:1453-61.
  59. Schlundt DG, Buchowski MS, Hargreaves MK, Hankin JH, Signorello LB, Blot WJ. Separate estimates of portion size were not essential for energy and nutrient estimation: Results from the Southern Community Cohort Food Frequency Questionnaire Pilot Study. Public Health Nutr 2007;10:245-51.
  60. Cohen SS, Signorello LB, Gammon MD, Blot WJ. Obesity and recent mammography use among black and white women in the Southern Community Cohort Study (United States). Cancer Causes Control 2007;18:765-73.
  61. Signorello LB, Schlundt DG, Cohen SS, Steinwandel MD, Buchowski MS, McLaughlin JK, Hargreaves MK, Blot WJ. Comparing diabetes prevalence between African Americans and Whites of similar socioeconomic status. Am J Public Health 2007;97:2260-7.
  62. Blot WJ, Signorello LB, Cohen SS, Ibrahim MA. Single leg separation prevalence among explanted Bjork-Shiley prosthetic heart valves. J Heart Valve Dis 2007;16:657-61.
  63. Cui Y, Peterson NB, Hargreaves MK, Wen W, Patel K, Drake J, Munro HM, Signorello LB, Blot WJ. Mammography use in the Southern Community Cohort Study (United States). J Health Care Poor Underserved 2007;18:102-17.
  64. Signorello LB, Tarone RE. A decline in breast cancer incidence. (Letter) N Engl J Med 2007;357:512-3.
  65. Fowke JH, Matthews CM, Buchowski MS, Signorello LB, Chang SS, Cookson MS, Blot WJ. Association between prostate-specific antigen and leptin, adiponectin, HbA1c or C-peptide among African-American and Caucasian men. Prostate Cancer Prostatic Dis 2008;11:264-9.
  66. Peterson NB, Murff H, Fowke JH, Cui Y, Hargreaves MK, Signorello LB, Blot WJ. Use of colonoscopy and flexible sigmoidoscopy among African-Americans and Whites in a low income population. Prev Chronic Dis 2008;5:A28.
  67. Egan KM, Signorello LB, Munro HM, Hargreaves MK, Hollis B, Blot WJ. Vitamin D insufficiency among African-Americans in the southeastern United States: Implications for cancer disparities (United States). Cancer Causes Control 2008;19:527-35
  68. Murff HJ, Peterson NB, Fowke JH, Hargreaves M, Signorello LB, Dittus RS, Zheng W, Blot WJ. Colonoscopy screening in African-Americans and Whites with affected first-degree relatives. Arch Int Med 2008;168:625-31.