Dr. Antoine
Malek
University
Hospital Zurich, Switzerland
Email:
antoine.malek1@gmail.com
Qualifications
1986 Ph.D.,
University of Zurich, Cairo
1971 B.Sc.,
Ain Shams University, Cairo
Publications (selected)
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Menezes V, Malek A and Keelan JA. Nanoparticulate
drug delivery in pregnancy: placental passage and fetal exposure. Prepared for:
Current Pharmaceutical Biotechnology, Special issue on Drugs and Pregnancy.
Editor: Professor Zaneta Kimber-Trojnar, Bentham Science Publishers, accepted
2011.
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Malek A. and
Mattison DR. Drugs and medicines in pregnancy: placental disposition of
opioids. Prepared for: Current Pharmaceutical Biotechnology, Special issue on
Drugs and Pregnancy. Editor: Professor Zaneta Kimber-Trojnar, Bentham Science
Publishers, accepted 2011.
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Semenov O,
Bersinger NB and Malek A. Human Placental Stem Cells: Biomedical Potential and
Clinical Relevance. Nova Publishers, accepted 2011.
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Semenov O, Koestenbauer S, Riegel M, Zech N, Zimmermann R, Zisch A, Malek
A.Multipotent mesenchymal stem cells from human placenta: critical
parameters for isolation and maintenance of 'stemness' after isolation. Am J
Obstet Gynecol, 2010, 2010; 202: 193.e1-193.e13.
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Wick P, Malek
A, Manser P, Meili D, Maeder-Althaus X, Diener L, Diener P, Zisch A, Harald F.
Krug HF and von Mandach U. Barrier capacity of human placenta for nanosized
materials. Environ Health Perspect, 2010; 118: 432-6.
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Malek A. and
Mattison DR. Drug development for use during pregnancy: impact of the placenta.
Expert Rev. Obstet. Gynecol, 2010; 5(4), 437–454.
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Malek A. In
vitro studies of ferric carboxymaltose on placental permeability using the dual
perfusion model of human placenta. Arzneimittelforschung/Drug Research, 2010;
60(6a): 354–361.
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Malek A,
Leiser R. Influence of the magnesium aspartate hydrochloride administration to
the maternal circuit on the aspartate concentration of the fetal circuit under
in vitro perfusion of human placenta. Eur J Obstet Gynecol Reprod Biol, 2009; 142: 12-17.
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Heinzelmann J, Enke U, Seyfarth L, Schleussner E, Malek A, Markert UR. Development of a human model to study homing behavior of immune cells into
decidua and placental villi under ex vivo conditions. Am J Reprod Immunol, 2009; 61: 19-25.
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Semenov OV, Malek A, Bittermann AG, Vörös J, Zisch AH. Engineered polyelectrolyte multilayer substrates for adhesion,
proliferation, and differentiation of human mesenchymal stem cells.Tissue Eng
Part A, 2009; 15: 2977-2990.
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Malek A,
Obrist C, Wenzinger S, von Mandach U. The impact of cocaine and heroin on the
placental transfer of methadone. Reprod Biol Endocrinol, 2009; 7: 61.
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Guller S, Ma
Y, Malek A, Di Santo S, Schneider H. Differential release of plasminogen
activator inhibitors (PAIs) during dual perfusion of human placenta:
implications in preeclampsia. Placenta, 2007; 28: 278-285.
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Malek A,
Bersinger NA, Di Santo S, Mueller MD, Sager R, Schneider H, Ghezzi F, Karousou
E, Passi A, De Luca G, Raio L. C-Reactive Protein Production in Term Human
Placental Tissue. Placenta, 2006; 27: 619-625.
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Portmann-Lanz
CB, Schoeberlein A, Huber A, Sager R, Malek A, Holzgreve W, Surbek DV.
Placental mesenchymal stem cells as potential autologous graft for pre- and
perinatal neuroregeneration. Am J Obstet Gynecol, 2006; 194: 664-673.
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Gupta AK,
Rusterholz C, Huppertz B, Malek A, Schneider H, Holzgreve W, Hahn S. A
comparative study of the effect of three different syncytiotrophoblast
micro-particles preparations on endothelial cells. Placenta, 2005; 26: 59-66.
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Gupta AK,
Holzgreve W, Huppertz B, Malek A, Schneider H, Hahn S. Detection of fetal DNA
and RNA in placenta-derived syncytiotrophoblast microparticles generated in
vitro. Clin Chem, 2004; 50: 2187-2190.
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Raio L, Ghezzi
F, Mueller MD, McDougall J, Malek A. Evidence of fetal C-reactive protein
urinary excretion in early gestation. Obstet Gynecol, 2003; 101: 1062-1063.
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Malek A. Ex
vivo human placenta models: transport of immunoglobulin G and its subclasses.
Vaccine, 2003; 21: 3362-3364.
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Guller S, Ma
Y, Raju U, Kadner S, Thung SF, Colasacco L, Malek A, Schneider H. Release of
oncofetal fibronectin from human placenta. Placenta, 2003; 24: 843-850.
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Di Santo S,
Malek A, Sager R, Andres A-C and Schneider H. Trophoblast viability in perfused
term placental tissue and explant cultures limited to 7-24 hours. Placenta, 2003; 24: 882-894.