Prof. Ming Zhan
The Methodist Hospital Research Institute, USA

Email: mzhan@tmhs.org

Qualifications

Ph.D., Molecular Biology, the University of Western Ontario, Canada

Publications (Selected)

1. Zhan M (editor) (2011). Computational biology of embryonic stem cells. Bentham Science Publishers Swistowska AM, Bettencourt da Cruz A, Han Y, Swistowski A, Liu Y, Shin S, Zhan M, Rao M, Zeng X (2010). Stage-specific role for Shh in dopaminergic differentiation of human embryonic stem cells induced by stromal cells. Stem CellDev19(1):71-82.
2. Han Y, Miller A, Mangada J, Liu Y, Swistowski A, Zhan M, Rao MS, Zeng X (2009). Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not Dopamine neurons. Plos One4(9):e7155.
3. Li H, Zhan M (2009). Identifying conserved and divergent transcriptional modules by cross-species matrix decomposition on microarray data. J Proteomics Bioinformatics 2(3):117-125.
4. Sun Y, Li H, Liu Y, Mattson MP, Rao MS, Zhan M (2008). Evolutionarily conserved transcriptional co-expression guiding embryonic stem cell differentiation. Plos One 3(10): e3406.
5. Li H, Zhan M (2008). Unraveling transcriptional regulatory programs by integrative analysis of microarray and transcription factor binding data. Bioinformatics 24(17):1874-1880.
6. Zhan M (2008). Genomic studies to explore self-renewal and differentiation properties of embryonic stem cells. Front Biosci 13:276-283.
7. Li H, Xuan J, Wang Y, Zhan M (2008). Inferring gene regulatory network. Front Biosci 13:263-275.
8. Zhan M (2007). Deciphering modular and dynamic behaviors of transcriptional networks. Genomic Medicine 1:19-28.
9. Li H, Sun Y, Zhan M (2007). The discovery of transcriptional modules by a two-stage decomposition approach. Bioinformatics 23(4):473-9.
10. Sun Y, Li H, Liu Y, Shin S, Mattson MP, Rao MS, Zhan M (2007). Cross-species transcriptional profiles establish a functional portrait of embryonic stem cells. Genomics89:22–35.
11. Li H, Sun Y, Zhan M (2007). Analysis of gene coexpression by B-spline based CoD estimation. J Bioinformatics & Systems Biol27:1-10.
12. Shin S, Sun Y, Liu Y, Khaner H, Svant S, Cai J, Xu XQ, Davidson BP, Stice SL, Smith AK, Goldman SA, Reubinoff BE, Zhan M, Rao MS, Chesnut JD (2007). Whole genome analysis of human neural stem cells derived from embryonic stem cells and stem and progenitor cells isolated from fetal tissue. Stem Cells25(5):1298–1306.
13. Li H, Zhan M (2006). Systematic intervention of transcription for identifying network response to disease and cellular phenotypes. Bioinformatics22(1):96–102.
14. Sun Y, Li H, Yang H, Rao MS, Zhan M (2006). Mechanisms controlling embryonic stem cell self-renewal and differentiation. Critical Rev Mammal Gene Expr. 16(3):211-32.
15. Li H, Liu Y, Shin S, SunY, LoringJ, Mattson MP, Rao MS, Zhan M (2006). Transcriptomeco expression map of human embryonic stem cells. BMC Genomics7(1):103.
16. Zhan M, Miura T, XuX, Rao MS (2005). Conservation and variation of gene regulation in embryonic stem cells assessed by comparative genomics. Cell BiochemBiophys 43(3):379-406.