Dr. Yanming Wang
Case Western Reserve University, USA

Email: yanming.wang@case.edu

Qualifications

1990-1995    Ph.D., Swiss Federal Institute of Technology, Organic Chemistry

1986-1989    M.Sc., Nankai University, Organic Chemistry

1982-1986    B.Sc., Nankai University, Chemistry

Publications (Selected)

1. Wang YM, Klunk WE, Debnath ML, Huang GF, Holt DP, Shao L., Mathis CA, Development of A PET/SPECT Agent for Amyloid Imaging in Alzheimer’s Disease, J. Molecular Neuroscience, 24:61-68 (2004).
2. Wei JJ, Wu CY, Lankin D, Gulrati A, Valyi-Nagy T, Cochran E, Pike VW, Kozikowski A, Wang YM, Development of Novel Amyloid Imaging Agents Based Upon Thioflavin S, Current Alzheimer Research, 2:109-114 (2005).
3. Wu CY, Pike VW, Wang YM,  Amyloid Imaging –From Bench to Bedside,  Current Topics in Developmental Biology, 70: 171-213 (2005).
4. Wu, Chunying, Cai, L., Wei, J., Pike, VW, Wang, YM,  Lipophilic Analogs of Thioflavin S as Novel Amyloid-Imaging Agents, Current Alzheimer Research, 2006 3:259-266.
5. Wu C, Tian D, Feng Y, Polak P, Wei JJ, Sharp A, Stankoff B, Lubetzki C, Zalc B, Mufson EJ, Gould RM, Feinstein DL, Wang YM, A Novel Myelin Probe that Readily Enter the Brain and Selectively Binds to Meylin Sheaths, J. Histochemistry and Cytochemistry. 2006, 54: 997 - 1004.
6. Stankoff B, Wang YM, Bottlaender M, Aigrot M-S,  Dolle F,  Wu C, Feinstein DL, Huang GF, Semah F, Mathis CA, Klunk WE, Gould RM, Lubetzki C, Zalc B,  Imaging of CNS myelin by positrons emission tomography (PET), Proceedings of the National Academy of Sciences, 2006, 103: 9304-9309.
7. Wu C, Wei J, Gao K, Wang YM (2007) Dibenzothiazoles as Novel Amyloid Imaging Agents, Bioorganic and Medicinal Chemistry, 15:2789-96.
8. Wu C-Y, Wei J-J,  Tian D-H, Feng Y, Miller R.H, Wang YM. Molecular Probes for Imaging Myelinated White Matter in CNS. J. Medicinal Chemistry, (2008) 51 (21) 6682-6688.
9. Tang Z, Du R, Jiang S, Wu C,  Barkauskas DS, Richey J, Molter J,  Lam M, Flask C, Gerson S, Dowlati A, Liu L, Halmos B, Lee Z, Wang YM, Kern JA, Ma PC (2008), Optimized MET Targeted Inhibition as Treatment Strategy for EGFR Inhibitor-Resistant Lung Cancer, British Journal of Cancer, 99:911-922.
10. Spring-Robinson C, Chandramouli V, Schumann WC, Faulhaber PF, Wang YM, Wu C-Y, Faramarz I-B, Muzic RF Jr. (2009) Uptake of [18F]6FDG by Skeletal Muscle is Responsive to Insulin Stimulation, Journal of  Nuclear Medicine  50:912-919.
11. Wang, YM, Wu C, Caprariello A.V, Somoza E, Zhu W, Wang C, Miller R. H, (2009) Direct Quantification of Myelin Changes in the Vertebrate Nervous System, Journal of Neuroscience, 29(46):14663–14669
12. Wang YM, Liu L, Wu C, Alina B, Somoza E, Zhu W, Gerson SL. (2009) Direct Quanification of Abasic Site for In Vivo Studies of DNA Damage and Repair. Nuclear Medicine Biology 36:975-983.
13. Wu C, Tang Z, Fan W, Zhu W, Wang C, Somoza E, Owino N, Ma PC, Wang YM, (2010) Radiosynthesis and Evaluation of [11C]SU11274 for In Vivo PET Imaging of MET Receptors, Journal of Medicinal Chemistry 53 (1):139–146.
14. Salem N, Kuang Y, Corn D, Erokwu B, Kolthammer JA, Tian H, Wu C, Wang F, Wang YM, Lee Z, (2011) [(Methyl)1-11C]-Acetate Metabolism in Hepatocellular Carcinoma, Molecular Imaging and Biology, 13:140-151.
15. Wang C, Popescu D, Wu C, Zhu J, Macklin W, Wang YM, In Situ Fluorescence Imaging of Myelination, (2010) Journal of Histochemistry and Cytochemistry, 58(7): 611–621.
16. Wu C, Popescu D, Wang C, Zhu W, Somoza E. A, Zhu J, Flask C. A, Miller R. H, Macklin W, Wang YM, (2010) A novel PET Marker for In Vivo Quantification of Myelination, Bioorganic and Medicinal Chemistry, 18:8592–8599.
17. Kuang Y, Salem, N, Tian H, Kolthammer JA, Corn DJ, Wu C, Wang, F, Wang YM, Lee Z, (2010) Imaging Lipid Synthesis in Hepatocellular Carcinoma with [Methyl-11C]Choline Correlated with Metabolites Study in vivo, J. Nuclear Medicine, 52: 98-106.
18. Wang C, Wu C, Popescu D, Zhu J, Macklin W, Miller R.H, Wang YM, Longitudinal Optical Imaging of Myelination Based on Near Infrared Fluorescence, (2011) Journal of Neuroscience  in press.
19. Muzic RF, Chandramouli C, Huang HM, Wu C, Wang YM, Ismail-Beigi F,(2011) Analysis of Metabolism of 6FDG: A PET Glucose Transport Tracer, Nuclear Medicine and Biology, in press.
20. Frullano L, Wang C, Miller, RH, Wang YM,  (2011) A Myelin-Specific MR-Contrast Agent for Imaging of Myelination, Journal of American Chemical Society, in press.