University of Virginia, USA

Professor

Email: rhk5i@virginia.edu

Qualifications

1964 Ph.D., Biophysics, Massachusetts Institute of Technology, USA

Publications (Selected)

1. Permyakov, E.A. and Kretsinger, R.H. "Cell Signaling, Beyond Cytosolic Calcium in Eukaryotes" J. Inorg. Biochem. (2009) 103 77-86.
2. Matsushima, N., Tanaka, T., and Kretsinger R.H. "Non-Globular Structures of Tandem Repeats in Proteins" Prot. Pept. Lett. (2009) 16 1297-1322.
3. Matsushima, N., Yoshida, H., Kumaki, Y., Kamiya, M., Tanaka, T., Izumi, Y. and Kretsinger, R.H. "Flexible Structures and Ligand Interactions of Tandem Repeats Consisting of Proline, Glycine, Asparagine, Serine, and/or Threonine Rich Oligopeptides in Proteins" Curr. Prot. Pept. Sci. (2008) 9 591-610.
4. Solodukhin, A.S., Kretsinger, R.H. and Sando, J.J. "Initial three-dimensional Reconstructions of Protein Kinase C delta from two-dimensional Crystals on Lipid Monolayers" Cellular Signalling (2007) 19 2033-2045.
5. Enkhbayar, P., Hikichi, K., Osaki, M. Kretsinger, R.H. and Matsushima, N. "310-Helices in Proteins Are Parahelices" Proteins-Structure Function and Bioinformatics (2006) 64 691-699.
6. Kretsinger, R.H. "Proteins and the Flow of Information in Cellular Function” in Molecular Imaging: FRET Microscopy and Spectroscopy pp 1 - 15 eds. A. Perisasamy and R.N. Day Oxford University Press (2005).
7. Ison, R.I., Hovmöller, S. and Kretsinger, R.H. "Proteins and their Shape Strings" IEEE Eng. Med. Biol. (2005) 24 41-49.
8. Matsushima, N., Enkhbayar, P., Kamiya, M., Masakatsu, O. and Kretsinger, R.H. "Leucine-rich Repeats (LRRs): Structure, Function, Evolution and Interaction with Ligands" Drug Design Reviews (2005) 2 305-322.
9. Matsushima, N., Tachi, N., Kuroki, Y., Enkhbayar, P., Osaki, M., Kamiya, M. and Kretsinger, R.H. "Structural analysis of leucine rich repeat (LRR) variants in proteins associated with human diseases" Cell. Mol. Life Sci. (2005) 62 2771-2791.
10. Nakayama, S., Kawasaki, H., and Kretsinger, R.H. "Parvalbumin" in A. Messerschmidt, M. Cygler and W. Bode (eds.) Handbook of Metalloproteins, vol 3 (John Wiley & Sons, Ltd.) (2004) 42 501-508.
11. Kretsinger, R.H., Hovmöller, S., and Ison, R.E. "Prediction of Protein Structure" Meth. Enz. (2004) 383 1-27.
12. Shumilin, I.A., Bauerle, R., Wu, J., Woodard, R.W., and Kretsinger, R.H. "Crystal structure of the reaction complex of 3-deoxy-D-arabino-heptulosonate-7-phosphate Synthase from Thermotoga maritima Refines the Catalytic Mechanism and Indicates a New Mechanism of Allosteric Regulation" J. Mol. Biol. (2004) 341 455-466.
13. Freye-Minks, C., Kretsinger, R.H., and Creutz, C.E. "Crystal Structure and Functional Characteristics of the T356D Mutant of Annexin VI" Biochemistry (2003) 42 620-630.
14. Shumilin, I.A. Bauerle, R., and Kretsinger, R.H. " High resolution structure of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase reveals a twist in the plane of bound phosphoenolpyruvate" Biochemistry (2003) 42 3766-3776.
15. Shumilin, I.A. Bauerle, R., Zhao, C., and Kretsinger, R.H. "Phospho-enol-pyruvate bound to 3-deoxy-D-arabino-heptulosonate-7-phosphate Synthase Flips upon Binding of the Feedback Inhibitor, Phenylalanine" J. Mol. Biol. (2002) 320 1147-1156.