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Dr. Manmohan Singh

Novartis Vaccines


Email: manmohan.singh@novartis.com


1992 Ph.D., Pharmaceutics, National Institute of Immunology, India

1988 M.S., Pharmaceutics, Sagar University, India

1986 B.S., Pharmacy, Sagar University, India

Publications (selected)

  1. Goodsell A, Zhou F, Gupta S,Singh Manmohan, Malyala P, Kazzaz J, Greer C, Legg H, Tang T, Zur Megede J, Srivastava R, Barnett SW, Donnelly JJ, Luciw PA, Polo J, O'Hagan DT, Vajdy M. Beta7-integrin-independent enhancement of mucosal and systemic anti-HIV antibody responses following combined mucosal and systemic gene delivery.Immunology.2008 Mar;123(3):378-89.
  2. Helson R, Olszewska W, Singh Manmohan, Megede JZ, Melero J.A., O’Hagan D, Openshaw P.J. Polylactide-co-glycolide (PLG) microparticles modify the immune response to DNA vaccination.Vaccine(2008) 6;26(6):753-761.
  3. Padma Malyala, James Chesko, Mildred Ugozzoli, Amanda Goodsell, Fengmin Zhou, Michael Vajdy, Derek T. O’Hagan and Manmohan SinghThe potency of the adjuvant, CpG oligos, is enhanced by encapsulation in PLG microparticles.Journal of Pharmaceutical Sciences. (2008) 97 (3),1155-1164.
  4. James Chesko, Manmohan Singh, Jina Kazzaz, Nikin Patel and Derek O’Hagan Characterization of antigens adsorbed to anionic PLG microparticles by XPS and TOF-SIMS.Journal of Pharmaceutical Sciences(2008) 97 (4) 1443-1453.
  5. Padma Malyala and Manmohan Singh. Endotoxin limits in formulations for Preclinical Research. Journal of Pharmaceutical Sciences.(2008) 97 (6), 2041-2044.
  6. Wendorf J, Chesko J, Kazzaz J, Ugozzoli M, Vajdy M, O'Hagan D, Singh Manmohan. A comparison of anionic nanoparticles and microparticles as vaccine delivery systems.Human Vaccines2008, Jan 15;4(1).
  7. Andreas Wack,Barbara C. Baudner,Anne K. Hilbert, Ilaria Manini,Sandra Nutia, Simona Tavarini, Hanno Scheffczik, Mildred Ugozzoli, Manmohan Singh, Jina Kazzaz, Emanuele Montomoli, Giuseppe Del Giudice, Rino Rappuoli, Derek T. O’Hagan.Combination adjuvants for the induction of potent, long-lasting antibody and T-cell responses to influenza vaccine in mice.Vaccine(2008) 26 (4), 552-556.
  8. Janet Wendorf, Manmohan Singh, Mildred Ugozzoli, Jina Kazzaz, James Chesko, Elawati Soenawan, and Derek O’Hagan A Practical Approach to the Use of Nanoparticles for Vaccine Delivery. J. Pharm. Sciences.(2006) Vol. 95 No. 12, 2738-2750.
  9. Walter Reiss, A Kumar, G. Jiang, J williams, A Bostick, S Conteh, J Aguiar, Manmohan Singh, Derek O’Hagan, Jeff Ulmer, T.L. Richie. Protection of Rhesus Monkeys by a DNA Prime/Poxvirus Boost Malaria Vaccine Depends on Optimal DNA Priming and Inclusion of Blood Stage AntigensPLoSOne,Oct 2007 , Vol. 10, 1-13.
  10. Manmohan Singh, Jia-Hwa Fang, Jina Kazzaz, Mildred Ugozzoli, James Chesko, Padma Malyala, Raj Dhaliwal, Rebecca Wei, Maninder Hora and Derek O’Hagan. A modified process for preparing cationic polylactide-co-glycolide microparticles with adsorbed DNA.International Journal of Pharmaceutics.(2006) Vol. 327, Pages 1-5.
  11. Manmohan Singh, Mildred Ugozolli, E. Soenawan, Amarjit Pannu, E. Pushnova. Judith Allen and Derek O’Hagan.Extent of Supercoiling in Plasmid DNA Vaccines: Should Restrictions Be RelaxedAmerican Journal of Drug Delivery(2006) Vol. 4 (4), 195-199.
  12. Michael Vajdy, Doris Coit, Angelica Medina-Selby, Mark Selby, John Hall, Celine Hu, Domenico Rosa, Manmohan Singh, Jina Kazzaz, Steve Nguyen, Steve Coates, Sergio Abrignani, Michael Houghton and Derek T. O’Hagan. Hepatitis C virus polyprotein vaccine formulations capable of inducing antibody and broad cellular immune responses.Journal of General Virology (2006) Vol. 87 2253-2262.
  13. Manmohan Singh, Mildred Ugozzoli, Jina Kazzaz, James Chesko, Elawati Soenawan, Mannucci Donatella, Mario Controni, Giuseppe del Guidice and Derek O’Hagan .Evaluation of Alternative Delivery Systems For Antigens and their comparison to Alum.Vaccine(2006) Vol.24 No.10, 1680-1686.
  14. Jina Kazzaz, Manmohan Singh, Mildred Ugozzoli, James Chesko and Derek O’Hagan.Encapsulation of theImmune PotentiatorsMPL and RC529 in PLG Microparticles Enhances Their Potency.Journal of Controlled Release.(2006) Vol.110 No.3, 566-573.
  15. James Chesko, Jina Kazzaz, Mildred Ugozzoli, Derek O’Hagan and Manmohan Singh.An investigation of the factors controlling the adsorption of protein antigens to anionic PLG microparticles.Journal of Pharmaceutical Sciences.Vol. 94, No. 11 (2005) 2510-2519.
  16. Gib Otten, M. Schafer, barbara Doe, Hong liu, Indresh srivastava, jan zur megede, Jina Kazzaz, Ying Lian, Manmohan Singh, Mildred Ugozolli, david Montefiori, Mark Lewis, David Driver, Thomas Dubensky, John Polo, John Donnelly, Derek O'Hagan, Susan Barnett and Jeff Ulmer. Enhanced Potency of Plasmid DNA Microparticle HIV Vaccines in Rhesus Macaques Using a Prime-Boost Regimen with Recombinant Proteins,Journal of Virology, Vol. 79 (2005) 8189-8200.
  17. Hang, Xie, Ihsan Gursel, B. Ivins, Manmohan Singh, Derek O’Hagan, Jefferey Ulmer and Derek O’Hagan. CpG oligodeoxynucleotides adsorbed onto PLG microparticles improve the immunogenicity and protective activity of the licensed anthrax vaccine. Infection and Immunity,Vol. 73, No. 2 (2005), 828-830.
  18. Manmohan Singh, James Chesko, Jina Kazzaz, Mildred Ugozzoli, Elaine Kan, Indresh Srivastava and Derek T. O’HaganAdsorption of a novel recombinant glycoprotein from HIV (Env gp120dV2SF162) to anionic PLG microparticles retains the structural integrity of the protein, while encapsulation in PLG microparticles does not.Pharmaceutical Research. Vol. 21 No. 12 (2004) 2156 – 2160.
  19. O’Hagan, D.T., Manmohan Singh, Ugozzoli, M., Paliard, X., Coates, S., Dong C. and Houghton, M. Cationic microparticles are a potent delivery system for a HCV DNA vaccine.VaccineVol. 23 (2004) 672-680.
  20. Michael Vajdy, Manmohan Singh, Jina Kazzaz, Elawati Soenawan, Mildred Ugozzoli, Fengmin Zhou, Indresh Srivastava, Qian Bin, Susan Barnett, John Donnelly, Paul Luciw, Lou Lourdes, David Montefiori and Derek T. O'Hagan. Mucosal and systemic anti-HIV responses in rhesus macaques following combinations of intra-nasal and parenteral immunizations.AIDS Research and Human Retorviruses. Vol. 20. No. 11 (2004) 1269-1281.

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