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Dr. Christian Joukhadar

Harvard Medical School, USA

Email: christian.joukhadar@jp-medical-research.com

Associate Professor, Harvard Medical School, USA

Publications (Selected)

  1. Kielstein JT, Eugbers C, Bode-Boeger SM, Martens-Lobenhoffer J, Haller H,Joukhadar C, Traunmüller F, Knitsch W, Hafer C, Burkhardt O. Dosing ofdaptomycin in intensive care unit patients with acute kidney injuryundergoing extended dialysis--a pharmacokinetic study. Nephrol DialTransplant. 2009 Dec 22. [Epub ahead of print] [impact; 3.568]
  2. Joukhadar C, Pillai S, Wennersten C, Moellering RC Jr, Eliopoulos GM. Lackof Bactericidal Antagonism or Synergism In Vitro Between Oxacillin andVancomycin Against Methicillin-Susceptible Strains of StaphylococcusAureus. Antimicrob Agents Chemother. 2009 Nov 23. [Epub ahead of print][impact; 4.716]
  3. Popovic M, Steinort D, Pillai S, Joukhadar C. Fosfomycin: an old, newfriend? Eur J Clin Microbiol Infect Dis. 2009 Nov 14. [Epub ahead of print][impact; 2.866]
  4. Kovar FM, Marsik CL, Jilma B, Mannhalter C, Joukhadar C, Wagner OF,Endler G. The inflammatory response is influenced by FXIII VAL 34 LEUpolymorphism in a human LPS model. Wien Klin Wochenschr. 2009Aug;121(15-16):515-519. [impact; 0.857]
  5. Schintler MV, Traunmüller F, Metzler J, Kreuzwirt G, Spendel S, Mauric O,Popovic M, Scharnagl E, Joukhadar C. High fosfomycin concentrations inbone and peripheral soft tissue in diabetic patients presenting with bacterialfoot infection. J Antimicrob Chemother. 2009 Sep;64(3):574-8. Epub 2009Jul 3. [impact; 4.328]
  6. Khadzhynov D, Joukhadar C, Peters H. Plasma and peritoneal dialysatelevels during daptomycin therapy for peritonitis. Am J Kidney Dis. 2009May;53(5):911-2. [impact; 4.822]
  7. Traunmüller F, Fille M, Thallinger C, Joukhadar C. Multiple-dosepharmacokinetics of telithromycin in peripheral soft tissues. Int J AntimicrobAgents. 2009 Jul;34(1):72-5. Epub 2009 Apr 19. [impact; 3.067]
  8. Joukhadar C, Thallinger C, P?ppl W, Kovar F, Konz KH, Joukhadar SM,Traunmüller F. Concentrations of voriconazole in healthy and inflamed lungin rats. Antimicrob Agents Chemother. 2009 Jun;53(6):2684-6. Epub 2009Mar 30. [impact; 4.716]
  9. Traunmüller F, Thallinger C, Hausdorfer J, Lambers C, Tzaneva S,Kampitsch T, Endler G, Joukhadar C. Tigecycline has no effect on cytokinerelease in an ex vivo endotoxin model of human whole blood. Int JAntimicrob Agents. 2009 Jun;33(6):583-6. Epub 2009 Jan 25 [impact;3.067]
  10. Thallinger C, Skorjanec S, Soleiman A, Tzaneva S, Griss J, Rous W, PoepplW, Weinlich G, Karimian-Teherani D, Joukhadar C. Orally administeredrapamycin, dacarbazine or both for treatment of human melanomaevaluated in severe combined immunodeficiency mice. Pharmacology.2008;82(3):233-8. Epub 2008 Sep 23. [impact; 1.894]
  11. Burklein D, Heyn J, Kirchhoff C, Ozimek A, Traunmuller F, Joukhadar C,Rothenburger M, Mutschler W, Heindl B. Analysis of plasma and peritonealfluid concentrations of daptomycin in a patient with Enterococcus faeciumperitonitis. Int J Antimicrob Agents. 2008 Oct;32(4):369-71. [impact;3.067]
  12. Ehrlich HJ, Muller M, Oh HM, Tambyah PA, Joukhadar C, Montomoli E,Fisher D, Berezuk G, Fritsch S, L?w-Baselli A, Vartian N, Bobrovsky R,Pavlova BG, P?llabauer EM, Kistner O, Barrett PN; Baxter H5N1 PandemicInfluenza Vaccine Clinical Study Team. A clinical trial of a whole-virus H5N1vaccine derived from cell culture. N Engl J Med. 2008 Jun 12;358(24):2573-84. [impact; 50.017]
  13. Sauermann R, Mayer-Helm BX, Petsch M, Popovic M, Thallinger C,Joukhadar C. Is experimental endotoxaemia in humans suitable forsimulating antibiotic pharmacokinetics in sepsis and septic shock? A pilotstudy using the model compound fosfomycin. Int J Antimicrob Agents. 2008Mar;31(3):291-2. [impact; 3.067]
  14. Marsik C, Kazemi-Shirazi L, Schickbauer T, Winkler S, Joukhadar C,Wagner OF, Endler G. C-reactive protein and all-cause mortality in a largehospital-based cohort. Clin Chem. 2008 Feb;54(2):343-9. [impact; 5.579]
  15. Stolle LB, Plock N, Joukhadar C, Arpi M, Emmertsen KJ, Buerger C,Riegels-Nielsen P, Kloft C. Pharmacokinetics of linezolid in bone tissueinvestigated by in vivo microdialysis. Scand J Infect Dis. 2008;40(1):24-9.[impact; 1.678]
  16. Kaehler S, Marsik C, Heinisch B, Thallinger C, Sauermann R, Kazemi-ShiraziL, Wagner O, Joukhadar C. S-ibuprofen effectively inhibits thromboxaneB2 levels and platelet function in an experimental model oflipopolysaccharide-stimulated and non-stimulated whole blood.Pharmacology. 2008;81(2):181-6. [impact; 1,894]
  17. Burkhardt O, Joukhadar C, Traunmüller F, Hadem J, Welte T, Kielstein JT, Elimination of daptomycin in a patient with acute renal failure undergoingextended daily dialysis. J Antimicrob Chemother. 2008 Jan;61(1):224-5.[impact; 4.328]
  18. Thallinger C, Buerger C, Plock N, Kljucar S, Wuenscher S, Sauermann R,Kloft C, Joukhadar C. Effect of severity of sepsis on tissue concentrationsof linezolid. J Antimicrob Chemother. 2008 Jan;61(1):173-6. Epub 2007 Nov13. [impact; 4.328]
  19. Sauermann R, Rothenburger M, Graninger W, Joukhadar C. Daptomycin: areview 4 years after first approval. Pharmacology. 2008;81(2):79-91. Epub2007 Oct 16. [impact; 1.894]
  20. Thallinger C, Rothenburger M, Marsik C, Wuenscher S, Popovic M, Endler G,Wagner O, Joukhadar C. Daptomycin does not exert immunomodulatoryeffects in an experimental endotoxin model of human whole blood.Pharmacology. 2008;81(1):57-62. Epub 2007 Sep 11. [impact; 1.894]
  21. Abrahim A, Luurtsema G, Bauer M, Karch R, Lubberink M, Pataraia E,Joukhadar C, Kletter K, Lammertsma AA, Baumgartner C, Müller M,Langer O. Peripheral metabolism of (R)-[(11)C]verapamil in epilepsypatients. Eur J Nucl Med Mol Imaging. 2008 Jan;35(1):116-23. Epub 2007Sep 11. [impact; 4.532]
  22. Sacher J, Mossaheb N, Spindelegger C, Klein N, Geiss-Granadia T,Sauermann R, Lackner E, Joukhadar C, Muller M, Kasper S. Effects ofOlanzapine and Ziprasidone on Glucose Tolerance in Healthy Volunteers
  23. Neuropsychopharmacology. 2007 Aug 22; [Epub ahead of print] [impact;6.157]
  24. Plock N, Buerger C, Joukhadar C, Kljucar S, Kloft C. Does Linezolid inhibitits own metabolism? - Population pharmacokinetics as a tool to explain theobserved nonlinearity in both healthy volunteers and septic patients. DrugMetab Dispos. 2007 Oct;35(10):1816-23. Epub 2007 Jul 16. [impact;3.907]
  25. Traunmuller F, Zeitlinger M, Zeleny P, Muller M, Joukhadar C, Pharmacokinetics of single- and multiple-dose oral clarithromycin in softtissues determined by microdialysis. Antimicrob Agents Chemother. 2007Sep;51(9):3185-9. Epub 2007 Jul 2. [impact; 4.309]
  26. Thallinger C, Werzowa J, Poeppl W, Kovar FM, Pratscher B, Valent P,Quehenberger P, Joukhadar C. Comparison of a Treatment StrategyCombining CCI-779 Plus DTIC Versus DTIC Monotreatment in HumanMelanoma in SCID Mice. J Invest Dermatol. 2007 May 17; [Epub ahead ofprint] [impact; 4.829]
  27. Langer O, Bauer M, Hammers A, Karch R, Pataraia E, Koepp MJ, Abrahim A,Luurtsema G, Brunner M, Sunder-Plassmann R, Zimprich F, Joukhadar C,Gentzsch S,Dudczak R, Kletter K, Muller M, Baumgartner C, Pharmacoresistance in Epilepsy: A Pilot PET Study with the P-GlycoproteinSubstrate R-[C]verapamil. Epilepsia. 2007 May 1; [Epub ahead of print][impact; 3.569]
  28. Chaurasia CS, Muller M, Bashaw ED, Benfeldt E, Bolinder J, Bullock R,Bungay PM, Delange EC, Derendorf H, Elmquist WF, Hammarlund-UdenaesM, Joukhadar C, Kellogg DL Jr, Lunte CE, Nordstrom CH, Rollema H,Sawchuk RJ, Cheung BW, Shah VP, Stahle L, Ungerstedt U, Welty DF, YeoH. AAPS-FDA Workshop White Paper: Microdialysis Principles, Applicationand Regulatory Perspectives. J Clin Pharmacol. 2007 May;47(5):589-603.[impact; 2.993]

Profile Details

Last Updated: August, 2012.

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