Dr. Xin-Fu Zhou

School of Pharmacy and Medical Sciences

University of South Australia, Adelaide, SA, 5000




1987-1990 Ph.D., University of Melbourne, Australia

1979-1982 M.S., Military General Hospital, Beijing, China

1973-1977 B.Sc., The Third Military Medical University, Chongqing, China

Research Fields


Medical Sciences

Publications (selected)

  1. Li CQ, Luo YW, Bi FF, Cui TT, Song L, Cao WY, Zhang JY, Li F, Xu JM, Hao W, Xing XW, Zhou FH,Zhou XF, Dai RP. Development of Anxiety-Like Behavior via Hippocampal IGF-2 Signaling in Offspring of Parental Morphine Exposure: Effect of Enriched Environment. Neuropsychopharmacology. 39(12):2777-87. 2014.
  2. Yang CR, Bai YY, Ruan CS, Zhou HF, Liu D, Wang XF, Shen LJ, Zheng HY, Zhou XF, Enhanced Aggressive Behaviour in a Mouse Model of Depression. Neurotox Res. 27: 129-142, 2015.
  3. Liu YH, Jiao SS, Wang YR, Bu XL, Yao XQ, Xiang Y, Wang QH, Wang L, Deng J, Li J, Zhou XF, Zhou HD, Wang YJ. Associations Between ApoEε4 Carrier Status and Serum BDNF Levels-New Insights into the Molecular Mechanism of ApoEε4 Actions in Alzheimer's Disease. Mol Neurobiol. 51(3):1271-7, 2015.
  4. Liu YH, Wang YR, Xiang Y, Zhou HD, Giunta B, Mañucat-Tan NB, Tan J, Zhou XF, Wang YJ. Clearance of Amyloid-Beta in Alzheimer's Disease: Shifting the Action Site from Center to Periphery. Mol Neurobiol. 51(1):1-7 2015.
  5. Zhou FH, Yu Y, Zhou XF, Xian CJ. Methotrexate chemotherapy triggers touch-evoked pain and increased CGRP-positive sensory fibres in the tibial periosteum of young rats. Bone 73:24-31, 2015.
  6. Ruan CS, Zhou FH, He ZY, Wang SF, Yang CR, Shen YJ, Guo Y, , Zhao HB, Chen L, D Liu, Liu J, Baune TB, Xiao ZC, Zhou XF. 2015, Mice deficient for wild type p53-induced phosphatase 1 display elevated anxiety- and depression-like behaviors. Neuroscience. 293:12-22., 2015.
  7. Jiao SS, Yao XQ, Liu YH, Wang QH, Zeng F, Lu JJ, Liu J, Zhu C, Shen LL, Liu CH, Wang YR, Zeng GH, Parikh A, Chen J, Liang CR, Yang Xiang Y, Bu XL, Deng J, Li J, Xu J, Zeng YQ, Xu X, Xu HW, Zhong JH, Zhou HD, Zhou XF#, Wang YJ# Edaravone alleviates Alzheimer’s disease-type pathologies and cognitive deficits. Proceedings of National Academy of Sciences, 112(16):5225-30, 2015. # equal contribution.
  8. Yao XQ, Jiao SS, Saadipour K, Zeng F, Wang Q-H, Zhu C, Shen LL, Gui-Hua Zeng1, Chun-Rong Liang1, Jin Wang2, Yu-Hui Liu1, Hua-Yan Hou3, Xu X, Su YP, Fan XT, Xiao HL, Lue LF, Zeng YQ, Giunta B, Zhong JH, Walker WG, Zhou HD, Tan J, Zhou XF#, Wang YJ#. p75NTR ectodomain is a physiological neuroprotective molecule against amyloid-beta toxicity in the brain of Alzheimer’s disease. Molecular Psychiatry Accepted on the 25th March, 2015. # Co-corresponding authors.
  9. LimY, Zhong JH and Zhou XF. Development of mature BDNF specific sandwich ELISA. J Neurochem. 134(1):75-85., 2015.
  10. Xiong J, Zhou LI, Lim Y, Yang M, Zhu YH, Li ZW, Fu DL, Zhou XF. Mature brain-derived neurotrophic factor and its receptor TrkB are upregulated in human glioma tissues. Oncol Lett. 2015 Jul;10(1):223-227.
  11. Jiao SS, Bu XL, Liu YH, Wang QH, Liu CH, Yao XQ, Zhou XF, Wang YJ. Differential levels of p75NTR ectodomain in CSF and blood in patients with Alzheimer's disease: a novel diagnostic marker. Transl Psychiatry. 2015 Oct 6;5:e650. doi: 10.1038/tp.2015.146.
  12. Xiang Y, Bu XL, Liu YH, Zhu C, Shen LL, Jiao SS, Zhu XY, Giunta B, Tan J, Song WH, Zhou HD, Zhou XF, Wang YJ. Physiological amyloid-beta clearance in the periphery and its therapeutic potential for Alzheimer's disease. Acta Neuropathol. 2015 Oct;130(4):487-99.
  13. Rong R, Wang YC, Hu LQ, He QQ, Zhou XF, Wang TH, Bu PL. Role of endogenous PDGF-BB in cultured cardiomyocytes exposed to hypoxia. Neuropeptides. 2015 Apr;50:43-9.
  14. Wang XY, Ba YC, Xiong LL, Li XL, Zou Y, Zhu YC, Zhou XF, Wang TH, Wang F, Tian HL, Li JT. Endogenous TGFβ1 Plays a Crucial Role in Functional Recovery After Traumatic Brain Injury Associated with Smad3 Signal in Rats. Neurochem Res. 2015 40(8):1671-80.
  15. Su YW, Chung R., Dwivedi PP, Chim SM Kuek V, Foster BK, Ruan CS, Zhou XF, Xu J,. Xian CJ:2016. Neurotrophin-3 induces BMP-2 and VEGF activities and promotes the bony repair of injured growth plate cartilage and bone in rats, Journal of Bone and Mineral Research. 1331(6):1258-74.
  16. Johnson ME, Lim Y, Senthilkumaran M, Zhou XF, Bobrovskaya L. 2015. Investigation of tyrosine hydroxylase and BDNF in a low-dose rotenone model of Parkinson's disease. J Chem Neuroanat. 70:33-41.
  17. Li F, Cao WY, Huang FL, Kang WJ, Zhong XL, Hu ZL, Wang HT, Zhang J, Zhang JY, Dai RP, Zhou XF, Li CQ. 2016. Roles of NMDA and dopamine in food-foraging decision-making strategies of rats in the social setting. BMC Neurosci.17(1):3.
  18. Han YC, Lim Y, Duffieldl MD, Li H, Liu J, Abdul Manaph NP, Yang M, Keating DJ, Zhou XF, 2016. Direct Reprogramming of Mouse Fibroblasts to Neural Stem Cells by Small Molecules. Stem Cells Int. 2016:4304916.
  19. Fang Y, Yao L, Li C, Wang J, Wang J, Chen S, Zhou XF, Liao H. 2016, The blockage of the Nogo/NgR signal pathway in microglia alleviates the formation of Aβ plaques and tau phosphorylation in APP/PS1 transgenic mice. J Neuroinflammation. 13(1):56. Liao and Zhou are corresponding authors.
  20. Wang QH, Wang YR, Zhang T, Jiao SS, Liu YH, Zeng F, Li J, Yao XQ, Zhou HD, Zhou XF and Wang YJ. 2016, Intramuscular delivery of p75NTR ectodomain by an AAV vector attenuates cognitive deficits and AD-like pathologies in APP/PS1 transgenic mice, J Neurochem., J Neurochem. 138:163-73.
  21. Li C, Wang J, Fang Y, Liu Y, Chen T, Sun H, Zhou XF, Liao H. 2016, Nafamostat Mesilate Improves Function Recovery after Stroke by Inhibiting Neuroinflammation in Rats. Brain Behaviors and Immunity, 56:230-45.
  22. Ruan CS, Yang CR, Luo HY, Li JY, Bobrovskaya L, and Zhou XF, 2016. Mice with Sort1 deficiency display normal cognition but elevated anxiety-like behaviour. Exp. Neurology, 281:99-108.
  23. Luo C, Zhong XL, Zhou FH, Li JY, Zhou P, Xu JM, Song B, Li CQ, Zhou XF, Dai RP. 2016. Peripheral Brain Derived Neurotrophic Factor Precursor Regulates Pain as an Inflammatory Mediator. Sci Rep 6:27171.
  24. Bai YY, Ruan CS, Yang CR , Li JY, Kang ZL, Zhou L, Liu D, Zeng YQ, Wang TH, Tian CF, Liao H, Bobrovskaya L and Zhou XF: 2016, ProBDNF Signalling Regulates Depression-like Behaviours in Rodents under Chronic Stress. Neuropsychopharmcology accepted on the 11th of June, 2016.
  25. Liu Y, Li C, Wang J, Fang Y, Sun H, Tao X, Zhou XF, Liao H. Nafamostat Mesilate Improves Neurological Outcome and Axonal Regeneration after Stroke in Rats. Mol Neurobiol. 2016 Jun 22.

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Last Updated: 2016-09-22

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