Author(s)

Ahmed M. Soliman^1*, Mahmoud Sedeik²

¹Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.
²Department of Poultry and Fish Diseases, Faculty of Veterinary Medicine, Alexandria University, Alexandria, Egypt.

The pharmacokinetics and tissue residue of tylosin in broiler chickens were studied after I.V. and oral administrations in a dose of 50 mg tylosin/kg.b.wt. Tylosin was obeyed a two-compartment open model following I.V. administration at a dose of 50 mg/kg.b.wt. The disposition kinetics of tylosin following I.V. administration revealed that tylosin was highly distributed with V_d(area) of 6 L/kg and eliminated with half-life (t_1/2β) equal to 7.29 hours. The disposition kinetics of tylosin following oral administration revealed that the maximum blood concentration (C_max) was 3.40 μg/ml attained at (t_max) of 1.08 hour. Tylosin was eliminated with half-life (t_1/2β) equal to 5.78 hours. The mean systemic bioavailability of tylosin after oral administration was 90.29%. Following repeated oral administration of 50 mg tylosin base/kg.b.wt once daily for 5 consecutive days, the blood (μg/ml) and tissue (μg/g) residues of tylosin showed that liver, kidney and lung contained the highest tylosin residues and completely disappeared from those tissues at 6 days after the last oral dose. Chickens should not be slaughtered for human consumption within the treatment and 6 days after the last oral administrations of tylosin.

Pharmacokinetics, Tylosin, Broiler Chickens, Bioavailability, Tissue Residue

Soliman, A. and Sedeik, M. (2016) Pharmacokinetics and Tissue Residues of Tylosin in Broiler Chickens. Pharmacology & Pharmacy, 7, 36-42. doi: 10.4236/pp.2016.71006.