Are Lipid Panels Altered by a Large Lunch Meal in Type 2 Diabetes?


Introduction: Recently, analyses of large heterogeneous databases have suggested that there are no differences whether “lipid panels” are drawn in the fed or fasted state, even in diabetic individuals. Whether this is true for individual diabetic patients is unknown. Methods: We studied eight type 2 diabetic individuals and measured serial lipid panels to determine the effect of a large lunch meal. A “Big Mac” equivalent meal was fed to each volunteer and blood for lipid assays was obtained at baseline and hourly for five hours following the meal. Results: The meal induced a significant elevation of glucose, insulin, and c-peptide in each volunteer. In addition, the following lipid parameters significantly changed from baseline concentration during the meal: total cholesterol, non-HDL cholesterol, LDL-cholesterol and triglycerides. Furthermore, the timing of the blood draw post meal also was a determinant of the lipid concentration. No significant concentration change occurred in HDL-cholesterol. Conclusions: In type 2 diabetic patients, lipid panels should be drawn in the fasting state unless the only lipid parameter of interest is HDL-cholesterol.

Share and Cite:

E. Duran-Valdez, A. Gutierrez and D. Schade, "Are Lipid Panels Altered by a Large Lunch Meal in Type 2 Diabetes?," Open Journal of Endocrine and Metabolic Diseases, Vol. 3 No. 2, 2013, pp. 99-102. doi: 10.4236/ojemd.2013.32015.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] B. Eliasson, J. Cederholm, K. Eeg-Olofsson, et al., “Clinical Usefulness of Different Lipid Measures for Prediction of Coronary Heart Disease in Type 2 Diabetes,” Diabetes Care, Vol. 35, No. 5, 2011, pp. 2095-2100. doi:10.2337/dc11-0209
[2] “American Diabetes Association 2012 Executive Summary: Standards of Medical Care in Diabetes,” Diabetes Care, Vol. 35, No. 1, 2012, pp. S4-S10.
[3] “Emerging Risk Factors Collaboration, Major Lipids, Apolipoproteins, and Risk of Vascular Disease,” Journal of the American Medical Association, Vol. 302, No. 18, 2009, pp. 1993-2000. doi:10.1001/jama.2009.1619
[4] S. Van Dieren, U. Nothlings, A. M. Van der Schouw, et al., “Non-Fasting Lipids and Risk of Cardiovascular Disease in Patients with Diabetes Mellitus,” Diabetologia, Vol. 54, No. 1, 2011, pp. 73-77. doi:10.1007/s00125-010-1945-z
[5] A. D. Gutierrez, E. Duran-Valdez, I. Robinson, D. Gonzalez de Serna and D. S. Schade, “Does Short-Term Vitamin C Reduce Cardiovascular Risk in Type 2 Diabetes?” Endocrine Practice, 2013, in press.
[6] S. Gregersen, D. Samocha-Bonet, L. K. Heilbronn and L. V. Campbell, “Inflammatory and Oxidative Stress Responses to High-Carbohydrate and High-Fat Meals in Healthy Humans,” Journal of Nutrition and Metabolism, Vol. 2012, 2012, Article ID: 238056. doi:10.1155/2012/238056
[7] M. F. Carroll and D. S. Schade, “The Dawn Phenomenon Revisited: Implications for Diabetes Therapy,” Endocrine Practice, Vol. 11, No. 1, 2005, pp. 55-64. doi:10.4158/EP.11.1.55
[8] R. J. Bondar and D. C. Mead, “Evaluation of Glucose-6-Phosphate Dehydrogenase from Leuconostoc Mesenteroides in the Hexokinase Method for Determining Glucose in Serum,” Clinical Chemistry, Vol. 20, No. 5, 1974, pp. 586-590.
[9] L. Andersen, B. Dinesen, P. N. Jorgensen, et al., “Enzyme Immunoassay for Intact Human Insulin in Serum or Plasma,” Clinical Chemistry, Vol. 39, No. 4, 1993, pp. 578-582.
[10] P. Fossati and L. Prencipe, “Serum Triglycerides Determined Colorimetrically with an Enzyme That Produces Hydrogen Peroxide,” Clinical Chemistry, Vol. 28, No. 10, 1982, pp. 2077-2080.
[11] C. C. Allain, L. S. Poon, C. S. Chan, et al., “Enzymatic Determination of Total Serum Cholesterol,” Clinical Chemistry, Vol. 20, No. 4, 1974, pp. 470-475.
[12] W. T. Friedewald, R. I. Levy and D. S. Fredrickson, “Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, without Use of the Preparative Ultracentrifuge,” Clinical Chemistry, Vol. 18, 1972, pp. 499-502.
[13] J. Hintze, “NCSS and PASS Number Cruncher Statistical System,” Jatsvukke Utah, 2001.
[14] M. R. Stoline, “The Status of Multiple Comparisons: Simultaneous Estimation of All Pairwise Comparisons in One-Way ANOVA Designs,” The American Statistician, Vol. 35, No. 3, 1981, pp. 134-141.
[15] S. Mora, N. Rifai, J. E. Buring, et al., “Fasting Compared with Nonfasting Lipids and Apolipoproteins for Predicting Incident Cardiovascular Events,” Circulation, Vol. 118, No. 10, 2008, pp. 993-1001. doi:10.1161/CIRCULATIONAHA.108.777334
[16] J. H. M. deVries, P. L. Zock, R. P. Mensink, et al., “Underestimation of Energy Intake by 3-d Records Compared with Energy Intake to Maintain Body Weight in 269 Nonobese Adults,” American Journal of Clinical Nutrition, Vol. 60, No. 6, 1994, pp. 855-860.

Copyright © 2023 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.