Method for Improving the Lateral Resolution of Near-Infrared (NIR) Single Optods: Application to Subcutaneous Vein Detection and Localization
Yasser S. Fawzy
Inovia Technologies Ltd., Vancouver, Canada.
DOI: 10.4236/opj.2012.24044   PDF    HTML     4,254 Downloads   6,568 Views  

Abstract

NIR backscattering measurements using single source-detector optical probe (optods) can detect absorption areas within deep tissue layer. However, such optods, are characterized by large separation distance between the source and detectors (>2 cm) and poor lateral resolution (>1 cm), which limits its usage for the localization of small absorption volumes embedded deep within the tissue such as subcutaneous veins. In this work a method to improve the accuracy of locating such absorption volumes (areas) using backscattered NIR measurements is suggested and investigated with the aim of developing an optical sensor for detecting and localizing large subcutaneous veins. The method is based on measuring the differential signal from three overlapping source-detector pairs arranged within the probe such that the total photon sensitivity profile of the probe is maximized along a narrow width area (within the central of the probe) and minimized along its sides. The location of the absorption areas is then determined when a peak maximum of the measured signal is detected. Monte Carlo simulation and light transport modeling was used to determine the optimum arrangement of each source-detector pair within the probe to create the required spatial sensitivity profile and demonstrate the validity of the method. The results showed that the differential optode has more than two times improvement in the lateral resolution compared to the standard optode. The result also showed that the differential probe can locate subcutaneous veins with diameter ~5 mm and embedded at ~1.5 cm depth. The method could have a potential for designing and developing an optical backscattering sensors for detecting and localizing large subcutaneous veins embedded <2 cm depths

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Y. Fawzy, "Method for Improving the Lateral Resolution of Near-Infrared (NIR) Single Optods: Application to Subcutaneous Vein Detection and Localization," Optics and Photonics Journal, Vol. 2 No. 4, 2012, pp. 352-357. doi: 10.4236/opj.2012.24044.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1] T. Vaithianathan, I. D. Tullis, N. Everdell, T Leung, A. Gibson, J. Meek and D. T. Delpy “Design of a Portable Near-Infrared System for Topographic Imaging of the Brain in Babies,” Review of Scientific Instruments, Vol. 75, No. 10, 2004, p. 3276. doi:10.1063/1.1775314
[2] M. A. O’Leary, D. A. Boas and B. Chance, “Experimental Images of Heterogeneous Turbid Media by Frequency-Domain Diffusing-Photon Tomography,” Optics Letters, Vol. 20, No. 5, 1995, pp. 426-428. doi:10.1364/OL.20.000426
[3] H. Eda, I. Oda, Y. Ito, Y. Wada, Y. Oikawa, Y. Tsunazawa, M. Takada, Y. Tsuchiya, Y. Yamashita, M. Oda, A. Sassaroli, Y. Yamada and M. Tamura, “Multichannel TimeResolved Optical Tomographic Imaging System,” Review of Scientific Instruments, Vol. 70, No. 9, 1999, p. 3595. doi:10.1063/1.1149965
[4] J. M. Murkin and M. Arango, “Near-Infrared Spectroscopy as an Index of Brain and Tissue Oxygenation,” British Journal of Anaesthesia, Vol. 103, Suppl. 1, 2009, pp. 3-13. doi:10.1093/bja/aep299
[5] N. Subhash, J. R. Mallia, S. S. Thomas, A. Mathews, P. Sebastian and J. Madhavan, “Oral Cancer Detection Using Diffuse Reflectance Spectral Ratio R540/R575 of Oxygenated Hemoglobin Bands,” Journal of Biomedical Optics, Vol. 11, No. 1, 2006, Article ID: 014018. doi:10.1117/1.2165184
[6] M. L. Flexman, M. A. Khalil, R. Al Abdi, H. K. Kim, C. J. Fong, E. Desperito, D. L. Hershman, R. L. Barbour and A. H. Hielscher, “Digital Optical Tomography System for Dynamic Breast Imaging,” Journal of Biomedical Optics, Vol. 16, No. 7, 2011, Article ID: 076014. doi:10.1117/1.3599955
[7] M. Ferrari, V. Cettolo and V. Quaresima, “Light SourceDetector Spacing of Near-Infrared-Based Tissue Oximeters and the Influence of Skin Blood Flow,” Journal of Applied Physiology, Vol. 100, No. 4, 2006, pp. 14261427. doi:10.1152/japplphysiol.01207.2005
[8] M. S. Patterson, S. Anderson, B. C. Wilson and E. K. Osei, “Absorption Spectroscopy in Tissue-Simulating Materials: A Theoretical and Experimental Study of Photon Paths,” Applied Optics, Vol. 34, No. 1, 1995, pp. 22-30. doi:10.1364/AO.34.000022
[9] E. Okada, M. Firbank and D. T. Delpy, “The Effect of Overlying Tissue on the Spatial Sensitivity Profile of Near-Infrared Spectroscopy,” Physics in Medicine and Biology, Vol. 40, No. 12, 1995, pp. 2093-2108. doi:10.1088/0031-9155/40/12/007
[10] D. A. Boas, K. Chen, D. Grebert and M. A. Franceschini, “Improving the Diffuse Optical Imaging Spatial Resolution of the Cerebral Hemodynamic Response to Brain Activation in Humans,” Optics Letters, Vol. 29, No. 13, 2004, pp. 1506-1508.
[11] H. Kawaguchi and E. Okada, “Evaluation of Image Reconstruction Algorithm for Near-Infrared Topography by Virtual Head Phantom,” Progress in Bimedical Optics and Imaging, Vol. 10, 2007, pp. 1-662906.
[12] J. C. Schotland, J. C. Haselgrove and J. S. Leigh, “Photon Hitting Density,” Applied Optics, 32, 1993, pp. 448-453. doi:10.1364/AO.32.000448
[13] Y. Fawzy, A. Youssef, M. El-Batanony and Y. Kadah, “Determination of the Optical Properties of A Two-Layer Tissue Model by Detecting Photons Migrating at Progressively Increasing Depths,” Applied Optics, Vol. 42, No. 31, 2003, pp. 6398-6411. doi:10.1364/AO.42.006398
[14] M. Keijzer, S. L. Jacques, S. A. Prahl and A. J. Welch, “Light Distributions in Artery Tissue: Monte Carlo Simulations for Finite-Diameter Lasers Beams,” Lasers in Medicine and Surgery, Vol. 9, No. 2, 1989, pp. 148-154. doi:10.1002/lsm.1900090210
[15] B. Lin, C. Kong, D. Tarng, T. Huang and G. Tang, “Anatomical Variation of the Internal Jugular Vein and Its Impact on Temporary Haemodialysis Vascular Access: An Ultra-Sonographic Survey in Uraemic Patients,” Nephrology Dialysis Transplantation, Vol. 13, No. 1, 1998, pp. 134-138. doi:10.1093/ndt/13.1.134
[16] V. Zharov, S. Ferguson, J. Eidt, P. Howard, L. Fink and M. Waner, “Infrared Imaging of Subcutaneous Veins,” Laser in Surgery and Medicine, Vol. 34, No. 1, 2006, pp. 56-61. doi:10.1002/lsm.10248
[17] H. P. Brecht, D. S. Prough, Y. Y. Petrov, I. Patrikeev, I. Y. Petrova, D. J. Deyo, I. Cicenaite and R. O. Esenaliev, “In Vivo Monitoring of Blood Oxygenation in Large Veins with a Triple-Wavelength Optoacoustic System,” Optics Express, Vol. 15, No. 24, 2007, pp. 16261-16269. doi:10.1364/OE.15.016261

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