Gastric Neuroendocrine Carcinoma in a Dog


A gastric biopsy specimen from a 14-year-old Yorkshire terrier was analysed using light microscopy, immunohistochemistry and transmission electron microscopy. The biopsies were obtained from a 3 × 3 × 4 cm mass located at the gastric cardia. Light microscopy revealed solid nests and sheets of tumour cells separated by abundant fibrovascular stroma in all gastric layers. The tumour cells were monomorphic, with eosinophilic cytoplasm and demonstrated palisading at the periphery. Nuclei were round to oval with densely packed chromatin and inconspicuous nucleoli. The tumour cells immunohistochemically stained strongly positive for chromogranin A, synaptophysin, and pan-cytokeratin. Electron microscopy revealed electron dense neurosecretory granules of 100 - 150 nm in diameter. Metastases were found in regional lymph nodes. Gastric neuroendocrine carcinoma was diagnosed, according to the histological, immunohistochemical and electron microscopic features.

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N. Herbach, S. Unterer and W. Hermanns, "Gastric Neuroendocrine Carcinoma in a Dog," Open Journal of Pathology, Vol. 2 No. 4, 2012, pp. 162-165. doi: 10.4236/ojpathology.2012.24031.

Conflicts of Interest

The authors declare no conflicts of interest.


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