Acute Toxicity and Antipyretic Activities of a Methanolic Extract of Alchornea cordifolia Leaves


Alchornea cordifolia (Euphorbiaceae) is a very prized plant among traditional healers in Africa. Its leaves are used for its antipyretic properties in traditional areas. The aim of our study is to determine the acute toxicity and the antipyretic activity of a methanolic extract of Alchornea cordifolia leaves. Acute toxicity was assessed by measuring mortality, changes in body weight, spontaneous movements, and normal rectal temperature in mice. Antipyretic activity was evaluated by brewer’s yeast-induced hyperpyrexia in rats according to Teotino method (1963). The antipyretic effect of methanolicextract of Alchornea cordifolia leaves was compared with paracetamol (100 mg/kg bw) orally. Groups of mice treated with doses of 6500; 3250; 1625 and 812.5mg/kg of the extract did not show any mortality, nor significant alteration of body weight, nor alteration of spontaneous movements. However, incomplete reversed dose-dependent hypothermic activity was observed with doses of 50.78; 101.56; 203.12; 406.25; and 812.5 mg/kg p.o. of the extract, showing acute toxicity of this plant. In the antipyretic assay, the extract with doses of 50.78; 101.56; 203.12; 406.25; and 812.5 mg/kg p.o. exhibited a significant dose-dependent antipyretic activity similar to paracetamol (100 mg/kg bw) in rats. Thus Alchornea cordifolia may inhibit prostaglandins-biosynthesis from hypothalamus. Our results support claims on its traditional uses in management of fever. However Alchornea cordifolia may affect hypothalamus not only during fever but also when body temperature is normal.

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K. Effo, G. Kouakou-Siransy, G. Irie-Nguessan, R. Sawadogo, I. Dally, A. Kamenan, L. Kouakou and J. Kablan-Brou, "Acute Toxicity and Antipyretic Activities of a Methanolic Extract of Alchornea cordifolia Leaves," Pharmacology & Pharmacy, Vol. 4 No. 7B, 2013, pp. 1-6. doi: 10.4236/pp.2013.47A2001.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] E. J. Adjanohoun, “Fiche Espèce: Alchornea cordifolia,” Bull Med Trad Pharm, Vol. 8, No. 2, 1994, pp. 203-213.
[2] A. O. Ajao, N.-O. Shonukan, B. FemiI-Onadeko, “Antibacterial Effect of Aqueous and Alcohol Extracts of Spondias mombin and Alchornea cordifolia, Two Local Antimicrobial Remedies,” International Journal of Crude Drug Research, Vol. 23, No. 2, 1985, pp. 67-72.
[3] A. Lamikanra, “Antimicrobial Spectrum of Alchornea cordifolia Leaf Extract,” Phytotherapy Research, Vol. 13, No. 1, 1999, pp. 67-69.<67::AID-PTR366>3.0.CO;2-F
[4] A. Lamikanra, A. O. Ogundani and F. O. Ogungbamila, “Antibacterial Constituents of Alchornea cordifolia Leaves,” Phytotherapy Research, Vol. 4, No. 5, 1990, pp. 198-200.
[5] L. Tona, K. Kambu, N. Ngimbi, N. Mesia, O. Penge, M. Lusakibanza, K. Cimanga, T. De Bruyne, S Apers, J Tooté, L. Pieters and A. J. Vlietinck, “Antiamoebic and Spasmolitic Activities of Extracts from Some Antidiarroeal Traditional Preparations Used in Kinshasa, Congo,” Phytomedicine, Vol. 4, No. 5, pp. 31-38.
[6] J. T. Banzouzi, R. Prado, H. Menan, A. Valentin, C. Roumestan, M. Mallie, Y. Pelissier and Y. Blache, “In Vitro Antiplasmodial Activity of Extracts of Alchornea cordifolia and Identification of an Active Constituent: Ellagic Acid,” Journal of Ethnopharmacology, Vol. 81, No. 3, 2002, pp. 399-401.
[7] M. H. Manga, D. Brkic, D. E. P. Marie and J. Quetin-Leclercq, “In Vivo Anti-Inflammatory Activity of Alchornea cordifolia (Schmach. & Thonn) Müll. Arg. (Euphorbiaceae), ” Journal of Ethnopharmacology, Vol. 92, No. 2-3, 2004, pp. 209-214.
[8] U. M. Teotino, L. P. Friz, A. Gandini and D. D. Bella, “Thio Derivatives of 2,3-Dihydro-4H-1,3-Benzoazin-4-one Synthesis and Pharmacological Properties,” Journal of Medicinal Chemistry, Vol. 6, No. 3, 1963, pp. 248-250.
[9] F. O. Ogungbamila and G. Samuelsson, “Smooth muscle relaxing flavonoids from Alchornea cordifolia,” Acta Pharmaceutica Nordica, Vol. 2, No. 6, 1990, pp. 421-422.
[10] R. Nia, D. H. Paper, G. Franz and E. E. Essien, “Anti-Angiogenic, Anti-Inflammatory and Anti-Oxidant Potential of an African Recipe: Alchornea cordifolia Seeds,” Acta Horticulturae, Vol. 678, 2005, pp. 91-96.
[11] G. A. Agbor, T. Leopold and N. Y. Jeanne, “The Antidiarrhoeal Activity of Alchornea cordifolia Leaf Extract,” Phytotherapy Research, Vol. 18, No. 11, 2004, pp. 873-876.
[12] S. Umukoro and A. C. Aladeokin, “Evaluation of the Anti-Stress and Anticonvulsant Activities of Leaf Extract of Alchornea cordifolia in Mice,” Journal of Ethnopharmacology, Vol. 127, No. 3, 2010, pp. 768-770.
[13] E. Makonnen, A. Debella, L. Zerihun, D. Abebe and F. Teka, “Antipyretic Properties of the Aqueous and Ethenol Extracts of the Leaves of Ocimum suave and Ocimum lamifolium in Mice,” Journal of Ethnopharmacology, Vol. 88, No. 1, 2003, pp. 85-91.
[14] N. Mascolo, R. Sharma, S. C. Jain and F. Capasso, “Ethnopharmacology of Calotropis procera Flowers,” Journal of Ethnopharmacology, Vol. 22, No. 2, 1988, pp. 211-221.
[15] M. Traoré, “Alchornea cordifolia. SCHMACH (Euphorbiaceae): Revue des activités Biologiques et L’etude de la Toxicité. Université de Bamako, Mali, 2004, 107 p.
[16] R. Howard, “Preoperative and Postoperative Pain Control,” Archives of Disease in Childhood, Vol. 69, No. 6, 1993, pp. 699-703.
[17] J. R. Vane, “The Evolution of Non-Steroidal Anti-Inflammatory Drugs and Their Mechanisms of Action,” Drugs, Vol. 33, Suppl. 1, 1987, pp. 18-27.
[18] A. S. Milton, “Prostaglandins and Fever,” Trends in Pharmacological Sciences, Vol. 3, 1982, pp. 490-492.
[19] M. D. Aronoff and E. G. Neilson, “Antipyretics: Mechanisms of Action and Clinical Use in Fever Suppression,” The American Journal of Medicine, Vol. 111, No. 4, 2001, pp. 304-315.
[20] A. Gepdiremen, V. Mshvildadze, H. Suleyman and R. Elias, “Acute and Chronic Anti-Inflammatory Effects of Hedera colchica in Rats,” Journal of Ethnopharmacology, Vol. 94, No. 1, 2004, pp. 191-195.

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