Effect of Metabolic Reactions on Thermoregulation in Human Males and Females Body ()

Saraswati Acharya, D. B. Gurung, V. P. Saxena

Department of Natural Sciences (Mathematics), School of Science, Kathmandu University, Kathmandu, Nepal.

Sagar Institute of Research and Technology, Bhopal, India.

**DOI: **10.4236/am.2013.45A005
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Department of Natural Sciences (Mathematics), School of Science, Kathmandu University, Kathmandu, Nepal.

Sagar Institute of Research and Technology, Bhopal, India.

The paper describes the study of metabolic effect relying on dermal thicknesses of males and females for temperature distribution of the layers of dermal part at various atmospheric temperatures. The study has been carried out for one dimensional steady and unsteady cases using finite element method. Lower percentage of muscle mass and higher percentage of adipose tissue in subcutaneous part of females result lower metabolic rate compared to males. Metabolism is considered as a heat source within the body tissue. The appropriate physical and physiological parameters together with suitable boundary conditions that affect the heat regulations have been incorporated in the model.

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Acharya, S. , Gurung, D. and Saxena, V. (2013) Effect of Metabolic Reactions on Thermoregulation in Human Males and Females Body. *Applied Mathematics*, **4**, 39-48. doi: 10.4236/am.2013.45A005.

1. Introduction

The human thermoregulatory is more complicated and incorporates more control principles than any actual technical control system. It behaves mathematically in a high nonlinear manner and contains multiple sensors, multiple feedback loops and multiple outputs.

Human are homeotherms as well as endotherms. In hot or cold regions thermoregulation is an evident in the form of sweating and shivering. The principles of heat transfer can be applied to the human body in order to determine how the body transfers heat. Heat is produced in the body by the continuous metabolism of nutrients which provides energy for the systems of the body and exchange heat with the environment (mainly by radiation and convection) and loses heat by evaporation of body fluids. The human body must maintain a consistent internal temperature in order to maintain healthy bodily functions. Therefore, excess heat must be dissipated from the body to keep it from overheating. When a person engages in elevated levels of physical activity, the body requires additional fuel which increases the metabolic rate and the rate of heat production. The body must then use additional methods to remove the additional heat produced in order to keep the internal temperature at a healthy level.

Thermal sensations are different among people even in the same environment. Even though the sensors render the same result regardless to the geographical position where the measurement being taken. This is not the case for persons. Indeed persons staying in very similar spaces subjected to the same climate and belonging to the common culture, issue very different opinions on thermal behavior due to the combination of large number of factors that affect the perception of human beings. Subject’s diagnosis is therefore an indispensable tool to achieve an overall evaluation of the study parameters. There is really no absolute standard for temperature in human body. In general temperature occurs within narrow ranges. Temperature also depends on behavioral action such as altering clothing, altering activities posture or location, changing the thermostatic setting, opening windows, complaining or leaving a space.

When measuring metabolic rates, many factors have to be taken into account. Each person has a different metabolic rate, and these rates can fluctuate when a person is performing certain activities or under certain environmental conditions. Even people who are in the same room can feel significant temperature differences due to their metabolic rates, which makes it very hard to find an optimal temperature for everyone in a given location. Food and drink habits may have an influence on metabolic rates, which indirectly influences thermal preferences. These effects may change depending on food and drink intake. Body shape is another factor that affects thermal preference. Heat dissipation depends on body surface area. A tall and skinny person has a larger surface-to-volume ratio, can dissipate heat more easily and can tolerate higher temperatures than a more rounded body shape [1,2].

Females differ from males in thermal responses to exgenous heat load and heat loss as well as to endogenous heat load during exercise because they usually have a large ratio of body surface to body mass, a greater subcutaneous fat content and lower exercise capacity. Also females’ sweating response to heat load is smaller than that of males but they are able to maintain their core body temperature on a similar level to that of males as a result of greater evaporative efficiency of sweating. Also the changing rate of sex hormone release during the menstrual cycle and ovulation periods modifies thermoregulation in females. So there are differences in body temperature and thermal responses to positive or negative heat loads depending on the phase of cycle and pre and post ovulation period [3].

The male sex hormone testosterone can increase the metabolic rate about 10% - 15%. But the female sex hormone estrogen may increase the metabolic rate a small amount but usually not enough to be significant. Males usually have higher metabolic rate than that of females of the same age because males tend to have a higher proportional of lean body mass than female of the same age. Conversely, females tend to have a higher proportional of fat cells and fat cells have a lower metabolic rate than lean muscle cells. But metabolic rate increases during pregnancy and lactation due to high energy requirement of producing fetal tissues than breast milk [4].

Metabolism is the total of all the chemical processes that occur in the cells of a body. It consists of anabolism in which molecules are built-up and catabolism in which enzymes break down the food consumed through hydrolysis and at the cellular level involves the process of phosphorolysis. Metabolism involves the chemical processes in the body in which energy is transferred between various chemical compounds and in which thermal energy is generated. If the rate of metabolic reactions increases, then the rate of energy generation also increases. In general females have a metabolic rate about 5% - 10% lower than males. The relationships for metabolic rate between human males and females dermal parts for two metabolic levels are shown in Figure 1.

Heat transfer problems are related in various discipline including biomedical sciences and have a role both in treatment and diagnosis. They can aid in predicting the time in the course of treatment or giving information on the temperature where thermometry is lacking. Though heat transfer in biological involves metabolic heat generation, conduction, convection, radiation, evaporation

Figure 1. Two metabolic levels (w/m^{3}) of human males and females [1,5].

and blood perfusion in human tissue but all physiological function generates heat by means of metabolic reaction in biological systems. The balance between the heat generation and loss from the body to the environment is very important to maintain body core temperature. Any physiological abnormality will disturb the homeostatic conditions for the temperature. Therefore the study of heat transfer under normal and abnormal conditions will be useful for various clinical conditions.

In this paper, we have developed a model with effect of metabolic reactions on thermoregulation in human males and females. For this we have assumed linear shape function for the temperature in each layer depending on the thickness of layers of dermal part. The thicknesses of layers have been measured perpendicularly from the outer surface towards the body core. Pennes bioheat equation is used considering the suitable physical and physiological parameters that affect the heat regulation in the layers. Computer simulation has been used for numerical results and graph of the temperatures profiles.

2. Mathematical Model

Skin membrane can be examined at various levels of complexity. In mathematical treatments of temperature distribution in dermal layers, the membrane can be regarded as a physical and physiological barrier with complex structure. Schematic diagram of temperature distribution model in the layers of dermal parts of human body is as shown in Figure 2.

The thickness of stratum corneum, stratum germinativum, papillary region, reticular region and subcutaneous tissue have been considered as respectively and _{ }and are the nodal temperatures at a distances and be the temperature function in the layers stratum corneum, stratum

Body core temperature = T_{b}

Figure 2. Schematic diagram of five layers of dermal part.

germinativum, papillary region, reticular region and subcutaneous tissue respectively.

Heat regulation in human body is characterized by blood flow in the blood vessels, metabolism and the conduction in tissue. The processes that govern the heat transfer in in-vivo tissue of human body at rest are perfusion, diffusion and metabolic heat generation. Thus the rate of change in total heat (Q) in a tissue element with respect to time t can be symbolically expressed as [6].

(1.1)

The rate of heat exchange in tissue element due to perfusion is based on Fick’s law of perfusion and it is given by

(1.2)

where, and _{ }are blood density, blood specific heat, blood flow per unit volume of tissue per second (blood perfusion rate), arteriole blood temperature, venular blood temperature respectively. We take, and then Equation (1.2) can be written as

(1.3)

The rate of heat exchange in tissue element due to diffusion is based on Fourier’s law of conduction and it is given by

(1.4)

where, K is the thermal conductivity of local tissue.

The rate of heat exchange in tissue element due to metabolic heat generation is given by

(1.5)

where, S is the metabolic heat generation rate per unit volume.

Now combining the Equations (1.3), (1.4) and (1.5) in the right of Equation (1.1), we get

(1.6)

where, and c are tissue density and tissue specific heat respectively.

The Equation (1.6) is the bio-heat equation suggested by Pennes’ in 1948.

If the body is exposed to the environment then the transfer of heat between the skin surface and environment is due to conduction, convection, radiation and evaporation. So the mixed boundary condition under study is given by

(1.7)

where are combined heat transfer coefficient due to convection and radiation, atmospheric temperature, latent heat of evaporation, rate of sweat evaporation and

is the partial derivative of T along the normal to the skin surface. Also the human body maintains its core temperature at a uniform temperature at 37˚C. Therefore, the boundary condition at the inner boundary is generally taken as

(1.8)

where, T_{b}_{ } is the body core temperature and l_{5} is the total thickness of skin and subcutaneous tissue.

3. Solution of the Problem

Using Euler-Lagrange formula in Equations (1.6) and (1.7), we get, following variational integral form of bioheat Equation [7,8]

(1.9)

where, is the thickness of the skin and subcutaneous tissue and.

The anatomical structure of human dermal part makes it reasonable to consider M and S zero in stratum corneum. In the model, the thermal conductivity in the layers of dermal part is considered as constant. All the assumptions for parameters in the layers of dermal part can be summed up as:

We write I separately for the five layers: I_{1 }for stratum corneum, I_{2 }for stratum germinativum, I_{3} for papillary region, I_{4} for reticular region and I_{5} for subcutaneous tissue as

(1.10)

Evaluating the integral with the help of layers wise assumptions, we get the following system of equations given below

where and are all constants depending upon the value of physical and physiological parameters of dermal layers.

We differentiate systems of linear equations with regard to the nodal temperatures and

and set Since (the body core temperature), we get the system of equations in matrix form:

(1.11)

where,

4. Numerical Results and Discussion

The following values of physical and physiological parameters have been used as prescribed by [1,4,5,9-11] to compute the numerical results. They are tabulated as Tables 1 and 2.

And, for nodal temperatures at, we are taking the equation with initial skin surface temperature 22˚C because at normal atmospheric temperatures skin surface temperature is considered 22˚C.

Table 1. Parameter values used in model.

Table 2. Thicknesses of dermal layers.

To solve the system of ordinary differential Equation (1.11) we use Crank-Nicolson method. According to the method, the system of Equation (1.11) can be written as [12].

(1.12)

where, is the time interval and is the matrix for initial nodal temperatures.

The results of the analysis for temperature distribution are presented through the graphs in the Figures 3-8 for steady state case and Figures 9-16 for unsteady state case.

The various temperature profiles have been studied. From Figures 3 and 4 we observe that males have slightly higher tissue temperature than females at each metabolic level at T_{∞} = 25˚C and E = 0 kg/m^{2}/sec. This is because males have higher metabolic rate in comparison to females. The results also suggest that there is less metabolic effect between temperature profiles (i) and (ii) at two metabolic levels in case of males due to relatively low percentage of subcutaneous fat than females. Same results we observe from Figures 5 and 6 at two metabolic levels at T_{∞} = 37˚C, E = 0.00004 kg/m^{2}/sec and Figures 7 and 8 at two metabolic levels at T_{∞} = 45˚C, E = 0.00008 kg/m^{2}/sec in human males and females body.

Moreover, we observe that in case of higher atmospheric temperatures, the effect of metabolic rate in temperature distribution is less in comparison to low

Figure 3. Temperature distribution of males at two metabolic level at T_{∞} = 25˚C & E = 0 kg/m^{2}/sec.

Figure 4. Temperature distribution of females at two metabolic level at T_{∞} = 25˚C & E = 0 kg/m^{2}/sec.

Figure 5. Temperature distribution of males at two metabolic level at T_{∞} = 37˚C & E = 0.00004 kg/m^{2}/sec.

Figure 6. Temperature distribution of females at two metabolic level at T_{∞ }= 37˚C & E = 0.00004 kg/m^{2}/sec.

Figure 7. Temperature distribution of males at two metabolic level at T_{∞} = 45˚C & E = 0.00008 kg/m^{2}/sec.

Figure 8. Temperature distribution of females at two metabolic level at T_{∞} = 45˚C & E = 0.00008 kg/m^{2}/sec.

Figure 9. Nodal Temperature of males at low metabolic rate at T_{∞} = 25˚C & E = 0 kg/m^{2}/sec.

Figure 10. Nodal Temperature of females at low metabolic rate at T_{∞} = 25˚C & E = 0 kg/m^{2}/sec.

Figure 11. Nodal Temperature of males at average metabolic rate at T_{∞} = 25˚C & E = 0 kg/m^{2}/sec.

Figure 12. Nodal Temperature of females at average metabolic rate at T_{∞} = 25˚C & E = 0 kg/m^{2}/sec.

Figure 13. Nodal Temperature of males at low metabolic rate at T∞ = 37˚C & E = 0.00004 kg/m^{2}/sec.

Figure 14. Nodal Temperature of females at low metabolic rate at T_{∞} = 37˚C & E = 0.00004 kg/m^{2}/sec.

Figure 15. Nodal Temperature of males at average metabolic rate at T_{∞} = 37˚C & E = 0.00004 kg/m^{2}/sec.

Figure 16. Nodal Temperature of females at average metabolic rate at T_{∞} = 37˚C & E = 0.00004 kg/m^{2}/sec.

atmospheric temperature. Shivering is the main source of internal heat production when T_{∞} falls below 37˚C. An increase in oxygen consumption is usually indicative of a rise in metabolic rate. Since shivering is a rapid involuntary contraction of muscle, oxygen consumption is used as an indicator for shivering. As well we observe that at T_{¥ }= 25˚C, E = 0 kg/m^{2}/sec the tissue temperature is higher than at T_{¥ }= 37˚C, E = 0.00004 kg/m^{2}/sec and T_{∞} = 45˚, E = 0.00008 kg/m^{2}/sec due to excessive sweating in the body.

Figures 9 and 10 reveal that temperature distribution profiles for nodal temperatures T_{i} (i = 0, 1, 2, 3, 4) of males are higher than that of females at metabolic rates S = 58 w/m^{3} and 52w/m^{3} at T_{∞} = 25˚C, E = 0 kg/m^{2}/sec. This is due to the fact that low percentage of subcutaneous fat of males result high metabolic rate. Same results are exhibited from Figures 11 and 12 at average metabolic rates at T_{∞} = 25˚C and E = 0 kg/m^{2}/sec. Figures 13 and 14, 15 and 16 at each metabolic levels at T_{∞} = 37˚C and E = 0.00004 kg/m^{2}/sec represent the same behaviors.

The significance effects of metabolism are observed at low atmospheric temperatures. At low temperature the blood vessels constrict, which in turn decrease heat carried by the blood to the surface, causing increase the metabolic heat effect to keep the body core temperature constant These figures show that the tissue temperatures at high atmospheric temperatures are higher as compared to lower atmospheric temperatures. This is because the heat gain is more from the surrounding at high atmospheric temperature due to increase in temperature gradient in skin surface.

5. Conclusions

The results are comparable with those obtained in [10,11] who considered only three layers of skin epidermis, dermis and subcutaneous tissue. The differences in the results whatsoever may be due to the extension up to five layers of dermal part having various thicknesses in males and females. The other reason may be the consideration of different metabolic rates at subcutaneous part of males and females.

Our model gives better profiles for temperature distribution in dermal layers. This is because the model has incorporated more feasible layers and has taken significant biophysical parameters in case of human males and females. After considering differences in metabolic heat production between sexes, males and females would differ in their physiological responses in temperature distribution. Furthermore, we observed that the thicknesses play significant role for temperatures distribution in human males and females body. The thinner layers lead to higher values of skin temperature than thicker layer. Also the significant effect in temperature distribution in males and females due to metabolism is seen being thicker skin layer of females. The subcutaneous fat in females contribute thicker skin layers than males. But in case of same thickness of skin layers in males and females, the metabolic effect does not alter significantly in temperature distribution in males and females body. So the purpose of the study is to determine heat responses in body tissue due to metabolic heat production according to gender differences. The results of the above figures clearly establish that such difference exists.

All of the previous developed models have not studied the gender wise temperature distribution in human dermal part. So it is still necessary for micro level study for temperature distribution model on the dermal layers of males and females. This study will help for further investigation in thermal disturbances recurring in the layers of dermal part due to external thermal loads to obtain a more accurate model for further applications. The study is important for the conceptual development for thermal behaviors of skin layers practically used in bio-thermo mechanic. The work will be useful to the researcher to study the gender wise thermoregulation.

Appendix 1

NOTES

Conflicts of Interest

The authors declare no conflicts of interest.

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