Application of on-line quality control for salvianolic acid B by near infrared spectroscopy
Jin-Wei Zhang, Yan Liu, Wei-Wei Liu, Yan-Ying Zhang
DOI: 10.4236/health.2009.13040   PDF    HTML     5,450 Downloads   9,549 Views  


OBJECTIVE: To study and establish quality con-trol model of the Salvianolic Acid B by Near In-frared Spectroscopy (NIRS), and to realize on-line quality control of extracting and purifying proc-esses of industrial scale herbal product manu-facturing. METHOD: NIR chromatography was obtained from on-line NIR detection of extract-ing process and purifying process. HPLC analysis was carried out to determine the con-tents of salvianolic acid B. Partial Least Squares Regression (PLS) was used to establish the model between the information between NIRS and HPLC. RESULTS: For extracting model: the optimum Near Infrared (NIR) wavelength range was 9815- 5430cm-1, R=0.9784, RMSEC=0.258; for puri-fying model: the optimum NIR wavelength range was 9815-5430cm-1, R=0.9776, RMSEC=4.02. The average relative error was <5%. CONCLUSION: NIR technique is applicable for on-line quality control in production of salvianolic acid B.

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Zhang, J. , Liu, Y. , Liu, W. and Zhang, Y. (2009) Application of on-line quality control for salvianolic acid B by near infrared spectroscopy. Health, 1, 244-248. doi: 10.4236/health.2009.13040.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] L. G. Weyer, (1985) Applied spectroscopy. [J]. Reviews, 21 (1-2), 1-8.
[2] G. A. Lang, (1994) NIRs monitor critical gasoline pa-rameters. [J]. Hydrocarbon Process, 72(2), 69-72.
[3] N. Wang and H. Wei, (2007) Application potentials of on-line near infrared spectroscopy technology in manu-facturing of traditional Chinese medicine. [J]. Journal of Shandong University of Traditional Chinese Medicine, 31(4), 350-353.
[4] L. J. Ni, X. H. Shi, X. J. Gao, etc. (2004) Research on the application of on-line detection and analytical technique by NIR in quality control of water extracting process of Salvia miltiorrhiza. [J]. Chinese Pharmaceutical Journal, 39(8), 628-630.
[5] S. K. Yan, L. A. Luo, Y. M. Wang, etc. (2006) Study on real-time control of extraction procedure of furitus gar-denia by near infrared spectroscopy. [J]. Spectroscopy and Spectral Analysis, 26(6), 1026-1030.
[6] N. L. Yang, H. B. Qu, Y. Y. Cheng, (2002) Rapid quanti-fication of total saponins of Panax notoginseng by near infrared spectroscopy. [J]. Journal of Zhejiang University (Engineering Science), 36(4), 463-466.
[7] N. L. Yang, H. B. Qu, Y. Y. Cheng, (2003) An approach to purifying process analysis of chinese herbal extracts using NIRS. [J]. Acta Chimica Sinica., 61(5), 742-747.
[8] Z. B. Yang, L. J. Luan, (2005) Rapid determination of purifying process of Fructus Aurantii extracts by NIR transmission spectroscopy. [J]. Chinese Pharmaceutical Journal, 40(8), 615-618.
[9] Z. L. Jiang, P. Zhu, X. Qin, (2007) The new advance on pharmaceutical and clinical application of near infrared spectroscopy. [J]. Strait Pharmaceutical Journal, 19(8), 118-120.
[10] W. Z. Lu, H. F. Yuan, G. T. Xu, etc., (2000) Modern NIR technology. [M]. Bei Jing: China Petrochemical Press, 6-26.
[11] X. L. Chu, H. F. Yuan, W. Z. Lu, (2006) Research and applications of near infrared spectroscopy in China in recent years. [J]. Analytical Instrumentation, (2), 1-9.

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