The Functions of the Amyloid Precursor Protein Gene and Its Derivative Peptides: III Pharmacological Studies
Peter K. Panegyres, Emily R. Atkins
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DOI: 10.4236/nm.2011.24053   PDF    HTML   XML   3,908 Downloads   7,194 Views  

Abstract

Pharmacological studies reveal APP and Aβ have interactions with glutamate and calcium, cytokines, copper/zinc chelators, secretases and presenilins, nicotinic receptors, acetycholinesterase, neurotrophins, non-steroidal anti-inflame-matory drugs, monoclonal antibodies to Aβ, protease inhibitors, oestrogen, homocysteine, immediate early genes such as c-fos or c-jun and cholesterol. These functional and pharmacological observations highlight the need for greater understanding of APP and Aβ in brain function and have implications for clinical trials.

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P. Panegyres and E. Atkins, "The Functions of the Amyloid Precursor Protein Gene and Its Derivative Peptides: III Pharmacological Studies," Neuroscience and Medicine, Vol. 2 No. 4, 2011, pp. 397-409. doi: 10.4236/nm.2011.24053.

Conflicts of Interest

The authors declare no conflicts of interest.

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