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Production and Utilization of L-Arabinose in China

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DOI: 10.4236/wjet.2018.63B004    254 Downloads   635 Views  


L-arabinose is a newly developed low-caloric monosaccharide, which has many biomedical and health effects, especially intestinal sucrase inhibition effect. L-arabinose is mainly produced by chemical or enzymatic hydrolysis of hemicellulose. The taste of L-arabinose is quite similar to that of sucrose, with approximately 50% of the sweetness. As a functional additive, L-arabinose can be used in medical and pharmaceutical applications for the treatment of diseases such as diabetes, chronic constipation, mineral absorption disorder and secondary bile acid formation disorder. However, L-arabinose has not been widely used in functional foods due to high price and lack of publicity and guidance. A comprehensive review of L-arabinose physicochemical properties, production, applications field, market statue and development direction is presented in this paper.

1. Introduction

The main sweeteners in China’s food are sucrose, starch sugars, artificial or natural high-intensity sweeteners, glucose, fructose, and sugar alcohols at present. Among them, sucrose is the most used sweetener, with an annual sales volume of 10 million tons and a sales price of 6100 - 6500 yuan per ton [1]. Sucrose, glucose and other products have a high glycemic index. Excess intake of such sweeteners can easily lead to excess energy in the body, causing tooth decay, obesity, diabetes, and cardiovascular disease. Therefore, the development of new varieties of sweeteners can not only maintain a good sweetness of food, but also reduce the risk of high blood sugar, high blood lipids and other diseases, and is currently a hot issue in the nutrition, medicine, and food industries.

L-arabinose is a newly developed low-caloric monosaccharide, which has many biomedical and health effects, especially intestinal sucrase inhibition effect. As a low-calorie sweetener [2] [3], L-arabinose has been approved by the American Medical Society and Japanese Ministry of Health to be used as an anti-obesity agent, nutritional supplements or prescription drugs. L-arabinose has been approved as a new resource food by Ministry of Health of China in 2008, which can be used in all foods except infant foods [4]. However, L-arabinose has not been widely used in functional foods due to high price and lack of publicity. L-arabinose is also widely used in medical field, chemistry, and biological fields as a kind of important chemical products.

2. Physicochemical Property and Existence of L-Arabinose in the Nature

2.1. Physicochemical Property of L-Arabinose

L-arabinose (C5H10O5, Mr = 150.13), an aldopentose, is initially isolated from arabic gum via complex chemical and physical methods [5] [6]. L-arabinose is an odorless white needle-like crystalline at room temperature, and it is soluble in water, slightly soluble in alcohol, insoluble in ether, methanol and acetone. Some property of L-arabinose: Melting point: 154˚C - 158˚C, Specific rotation [α] 20D (H2O, 24 h) +100 ~ + 104˚, relative density 1.585 [4] [7]. The sweetness of L-arabinose is about half of sucrose.

Linear form of L-arabinose is having a carbonyl group (C1) at the top of the carbon chain. The C-5 linked oxygen atom of 1.1 carries out nucleophilic attack on the carbonyl to give a cyclic structure 1.2, which forms β-L-arabinose 1.3 and α-L-arabinose 1.4 epimers due to the different spatial arrangement of the newly formed chiral C-1 atom (Figure 1).

2.2. Existence of L-Arabinose in the Nature

Free L-arabinose rarely exists in the nature, it only been found in the core of coniferous trees [8]. As a component of heteropolysaccharides that is found in gum, hemicellulose, bacterial polysaccharides and some glycoside, L-arabinose exists in the form of β-L-arabinose. Figure 2(a) shows the presence of L-arabinose in corn cob hemicellulose: the backbone is β-1,4-conjugated D-xylan, which can be combined with the hemiacetal hydroxyl of L-arabinose in the side chain at both the 2 and 3 positions of the xylose residue. Typically, more than 61% of L-arabinose is present at the non-reducing end [9]. However, L-arabinose exists mostly in the form of L-arabinose-oligosaccharides in sugar beet pectin: L-arabinose oligosaccharides (with a degree of polymerization of 10 - 20 in multiple forms and shapes) combined with the backbone of the pectin

Figure 1. Transition of L-arabinose from linearity to circularity.

Figure 2. Structure of hemicellulose: (a) Structure of maize hemicellulose modified from L. saulnier; (b) Structure of sugar beet pectin modified from A. voragen.

that consisted by D-galacturonic acid and rhamnose both at the 3 or 4 positions of the rhamnoseresidue [10] [11] (Figure 2(b)).

3. L-Arabinose Production

3.1. Production Statue of L-Arabinose

As a newly developed functional sugar, L-arabinose generally produced by hydrolysis of biomass that rich in L-arabinose residue such as vegetable gums [5] [12], corncob [13] [14], beet pulp [15], bagasse [16] and other materials [17]. L-arabinose can also prepared by chemical or biological synthesis methods, but both methods have shortcomings of high costs, difficult to separate, so it is rarely used in commercial production [18].

Domestic enterprises with a certain scale mainly include: Jinan healtang Biotech Co., Ltd., Xiamen Thomson Biotech Co., Ltd., Shandong Futase Co., Ltd., Jilin Huakang Pharmaceutical, Danisco (China) Co., Ltd., and Shandong Longlive Biotech Co., Ltd., Shandong Tanglikang Co., Ltd. Among them, Jinan Healtang Biotech Co., Ltd. is the largest producer of L-arabinose sugar in China which has the world’s first 1000 ton production device.

As a new functional sweetener, L-arabinose has huge market space in people with diabetes, obesity, and health care food products. With the improvement of people’s awareness, and deepening of research, L-arabinose will be more widely used in the fields of food industry, medicine and cosmetics, it will make a greater contribution in promoting human health and improving people’s life quality.

3.2. Problems Exist in L-Arabinose Production

L-arabinose can be prepared by enzymatic hydrolysis of hemicellulose, chemical synthesis, and biotransformation. However, certain problems exist in those methods.

1) Acid hydrolysis of corn bran, sugar cane pulp and other high L-arabinose content biomass: this method includes alkaline extraction and acid hydrolysis of Arabinoxylan. it is the most mature method with relative high yields, however obvious drawbacks also exists: ① harmful substances generates in high alkaline concentration and extraction temperature environment; ② a lot of salts generated in neutralization process makes subsequent crystallization process more complex, consumes more energy and time leading to higher production costs; ③ large-scale use of strong base and acid not only cause corrosion of equipment, but also has the potential of polluting the environment since a large amount of industrial waste is produced.

2) Acid hydrolysis of Arabic gum: the mixture of L-arabinose, xylose, rhamnose, galactose and other monosaccharides is obtained by acid hydrolysis of Gum Arabic. After the mixture is neutralized, yeast fermentation is used to remove fermented carbohydrates (such as galactose and glucose). It was then crystallized in methanol to give crude L-arabinose which was subsequently recrystallized from 90% ethanol to give pure L-arabinose crystal that approximately have a yield of 15.6% and 97.5% purity.

This way also exists some drawbacks: ① large-scale use of acid not only cause corrosion of equipment, but also has the potential of polluting the environment since a large amount of salts is produced. ② Yeast fermentation process is the most time and energy consuming step in the whole process as sterilization (consumes large amount of energy), yeast growth and consumes fermented carbohydrates (needs more than 24 h) is required, leading to lower productivity and higher production costs. ③ It is costly to use gum arabic to produce L-arabinose since gum arabic itself is in low production and high price.

3) Enzyme hydrolysis of high L-arabinose content biomass: this method effectively integrates the above two methods and avoids its’ disadvantages. It is a more practical, environmental protection and efficient way. This method uses cellulase and arabinoxylanse to hydrolyze high L-arabinose content biomass and the hydrolysate is then fermented by yeast to get rid of fermented carbohydrates. The method has the advantages of mild reaction conditions, strong specificity, and simple purification steps. The problem with this method is that the activity of cellulase or arabinoxylanase is not high and the hydrolysis time is relatively long, and the price of cellulase or arabinoxylanase is too high compared to hydrochloric acid and sulfuric acid, resulting in higher investment cost.

4) Chemical or biological synthesis of L-arabinose: L-arabinose can also be prepared by chemical synthesis or biotransformation. For example, through a series of addition reaction, ring opening, dehydrogenation and other steps, L-arabinose is obtained from dihydropyran. L-arabinose can also be obtained from L-ribose catalyzed by L-arabinose isomerase, while the L-ribose is obtained from L-ribitol catalyzed by acetobacter. A variety of optical isomers is produced no matter by chemical synthesis or biotransformation resulting in low production efficiency and high production costs, this is because separation and purification of optical isomers remains the bottleneck of global industrial crystallization separation.

4. Physiological Activity of L-Arabinose

As a newly developed functional sugar, L-arabinose mainly has the following features.

4.1. Specifically Inhibition Effect on Sucrase (α-Glucosidase) Activity

Compared with the other functional sugar, the representative physiological activity of L-arabinose is that it specifically inhibits intestine sucrase activity, thereby inhibiting the hydrolysis and sbsorption of sucrose, and reducing the magnitude of hyperglycemia. G. Semenza [19] found that the rabbit intestinal sucrase can be non-competitive inhibited by L-arabinose in both 10 mM and 50 mM concentration, with the inhibition rate 65% and 80%, respectively.

Researches revealed that only L-arabinose can non-competitive inhibit intestinal mucosa sucrase activity, while the D-arabinose or L-arabinbiose had no such activity, and the binding constant of L-arabinose with sucrase is 12 times that of sucrose with sucrase. At the same time, L-Arabinose has no significant inhibition effect on pancreas amylase, intestinal mucosa maltase, isomaltase, trehalase, lactase [2] [20] [21].

4.2. Hypolipidemic and Hypoglycemic Effect

L-arabinose has hypolipidemic and hypoglycemic effect which can prevent effectively from some metabolic diseases, such as obesity, diabetes. The intervention experiment of L-arabinose on high fat and high fat feeding rats and mice shows that L-arabinose can significantly reduce the fasting blood glucose, enhance glucose tolerance, and can effectively slow the growth of weight, compared with the control group [22] [23].

Han [24] confirmed that L-arabinose can reduce the fat index, inhibit and eliminate the accumulation of fat, thus to achieve the effect of weight loss on high fat and high fat feeding rabbits. Liu [3] and Shibanuma [25] tested the effects of L-arabinose on adults postprandial glucose levels and body weight index. Results shown that 1) the postprandial glycemic index of the experimental group supplemented with ≥3% of L-arabinose were significantly lower than that of the control group after 30 days in the postprandial blood glucose test; 2) compared with the normal diet obese group, the intervention group supplemented with ≥ 5% of L-arabinose (20 obese subjects) average decreased 5.5 kg after 6 months, indicating that L-arabinose significantly reduce postprandial glycemic index and has a slimming effect.

4.3. Promote Bifidobacterium Proliferation and Regulate Intestinal Balance

Research shows that the L-arabinose content in the various dietary fiber residue decreases significantly when it go through rat or human digestive tract, in where L-arabinose is dissolved and absorbed as a monosaccharide or oligosaccharide and then used by intestinal bacteria [26].

This is because L-arabinose residue is mainly present at the non-reducing end of the side chain (Figure 2(a)), which easily hydrolysis to free sugars in the acid environment of the stomach and then implement the functional characteristics of inhibition of blood glucose elevation, reduction of serum neutral fat and cholesterol concentration, proliferation of intestinal bifidobacteria, and so on. Studies show that L-arabinose promotes the growth of bifidobacteria thereby enhancing the body’s immune system and control weight gain in mice [27]. To the other hand, L-arabinose itself is difficult to be absorbed and utilized to generate energy in the body and the non-utilized part can be excreted from the urine so it will not lead to obesity.

4.4. Change of Skeletal Muscle Composition

Skeletal muscle is the place using sugar and insulin, change of skeletal muscle composition affects the insulin sensitivity. Research shows that the number of type I muscle fibers increases significantly while type II muscle fibers decreases after long-term utilization of L-arabinose, so taking L-arabinose can ameliorate type 2 diabetes mellitus symptoms since type I muscle fibers effectively improve insulin resistance [23] [28] [29].

5. Applications of L-Arabinose

Having the effects of low calorie value, specifically inhibit intestine sucrase activity, proliferation of intestinal bifidobacteria and other characteristics, L-arabinose is widely used in the food processing industry, chemistry, and biological fields as an important chemical products (Table 1).

L-arabinose is white powdery crystal under normal temperature and pressure, it is odorless and easily soluble in water. L-arabinose’s taste is similar to that of sucrose with about 50% of sucrose sweetness, it can be used as a sucrose alternatives. As it can specifically inhibit sucrose activity and regulate intestinal balance,

Table 1. Overview of the L-arabinose applications.

L-arabinose can be used as a functional food addictive for alleviating hypertension, hyperglycemia, hyperlipemia. As L-arabinose has fine food compatibility, it can be used in beverage products, candy, baked foods. L-arabinose can help solve “frosting” of chocolate and “sandy” of candy. As a reducing monosaccharide, L-arabinose contains an aldehyde group, which reacts with the amino acids, proteins and other substances (Maillard browning reaction) to form unique flavor and more bright color in the preparation of baked foods.

L-arabinose can be used as a non-prescription drugs as an anti-obesity nutritional supplements, or as a medicine pharmaceutical excipients and filling agents for syrups and tablets since it is difficult to be absorbed and utilized to generate energy in the body and the non-utilized part can be excreted from the urine.

L-arabinose can also be used for the synthesis of important pharmaceutical intermediates. Five anti-hepatitis B drugs entered into the Phase three clinical trials globally in 2010-2014, two of which uses L-arabinose as raw material, namely Clevudine (L-FMAU) of the Korean Bukwang Pharmaceuticals and Telbivudine of the United States Idenix Pharmaceuticals. These two drugs able to specifically inhibit the hepatotropic DNA viruses without an impact on the DNA polymerase and mitochondrial function, currently it has been widely used in the clinical treatment of hepatitis B.

L-arabinose is an ideal synthesis intermediates for flavors: study shown that flavor synthesized from L-arabinose has a soft, rich aroma, which is more natural and plump aroma. An increasing number of foreign flavor companies are trying to use L-arabinose in the production of Synthetic essence.

A new metal-organic frame thus calcium-L-arabinose complexes has been synthesized and characterized using L-arabinose as a raw material. Results show that the compound is not a halide, and the water and methanol molecules are not coordinated with the calcium ion. Calcium(II) is eight-coordinated, binding to four sugar moieties via O(1), O(2) of two molecules and O(3), O(4) of the other two, with O(4) being deprotonated (Figure 3).

Problems in Utilization of L-Arabinose

L-arabinose monomers are rarely present in nature. It is difficult to separate L-arabinose crystal from L-arabinose-xylose liquor resulting in lower product yield and higher price, which limits the L-arabinose applications in various fields.

With the continuous promotion of L-arabinose used in food additives, health products, medicine, biotransformation and organic synthesis, L-arabinose demand and production is growing rapidly since 2002. The global L-arabinose production has increased fourfold, from the initial 375 t to 9000 t, with an average annual growth rate of 30% during 2002 to 2014. With the progress of L-arabinose isolation technology, the production costs and selling prices are further reduced. In 2014-2018, the global demand for L-arabinose stabilized at more than 8000 tons. Although the selling prices is reduced from 0.30 million Yuan/Ton of 2002 to 0.15 million Yuan/Ton of 2017, it is still too high for food fields or daily usage since it is 25 times higher than that of sucrose(about 6500 Yuan/Ton).

Unscientific consumption of L-arabinose can cause adverse reactions: excessive

Figure 3. Molecular structure of calcium arabinose complexes.

consumption of L-arabinose can cause abdominal distension, diarrhea and other intestinal disorders. This is because a large amount of carbohydrates, which is not digested and absorbed in the small intestine, enter the large intestine and promote the proliferation of beneficial bacteria (such as Bifidobacterium and acidophilus), resulting in excessive intestinal gas production. Therefore, patients with severe digestive and absorption disorders, intestinal inflammation, chronic intestinal diseases, partial intestinal obstruction, colonic ulcers, and flatulence are not suitable to use L-arabinose as food addictive.

6. Conclusions

Although L-arabinose demand and production is growing rapidly since 2002, most people don’t know this new functional sweetener very much. It’s urgent to increase the scientific propaganda and market promotion of L-arabinose. The L-arabinose required for different purposes is different: dosage for auxiliary hypoglycemic is 3% - 5% of the sucrose content; dosage for weight loss is 10-15 grams TID; dosage for adjusting the intestinal flora is 3 - 5 grams TID. In order to achieve better results and avoid problems such as diarrhea and abdominal distension, it is recommended to take the prescribed dosage of L-arabinose before or during meals.

Although L-arabinose is widely exists in the nature, its relatively low in content and is difficult to separate from other monosaccharides which combine with L-arabinose to form hemicellulose. Acid hydrolysis of biomass contains alkaline extraction and acid hydrolysis of arabinoxylan, this method exists obvious drawbacks such as corrosion of equipment, potential of polluting the environment, and complex of procedures. Chemical synthesis or biotransformation method is not yet mature, since separation and purification of optical isomers remains the bottleneck of global industrial crystallization separation.

Research on enzyme hydrolysis of biomass to produce L-arabinose is the hotspot in recent years, a number of domestic and foreign companies have successfully developed the enzymatic production of L-arabinose, but production costs are still high since the activity of cellulase or arabinoxylanase is not high and the hydrolysis process is time consuming. However, Shandong Futase, Jinan Healtang use xylose mother liquor to produce L-arabinose, which significantly reduces the production costs. For now, the enzyme (microbial fermentation) is the most advanced technology in L-arabinose. To improve downstream industries (separation, purification and crystallization) of L-arabinose is the key in reducing manufacturing costs and increasing the production scale.

As an emerging healthy sugar, L-arabinose is expected to be widely used in household foods such as table sucrose, dairy products, cakes, bread, children’s food, ice cream, beverages, desserts, and chocolate. The main factor that restricts the large-scale application of L-arabinose is that the price is too high, so the development of lower-cost L-arabinose syrup and L-arabinose-xylose syrup will effectively promote its application scope and scale.


This project was supported by the National Natural Science Foundation of China Youth Science Foundation (81701171), Science and Technology Program of Guangdong (2017B030314123) and the Program of Guangdong Academy of Sciences (2016GDASPT-0108, 2017GDASCX-0105).

Conflicts of Interest

The authors declare no conflicts of interest regarding the publication of this paper.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Hu, B. , Li, H. , Wang, Q. , Tan, Y. , Chen, R. , Li, J. , Ban, W. and Liang, L. (2018) Production and Utilization of L-Arabinose in China. World Journal of Engineering and Technology, 6, 24-36. doi: 10.4236/wjet.2018.63B004.


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