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Two Flavones from Acanthospermum hispidum DC and Their Antibacterial Activity

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DOI: 10.4236/ijoc.2011.13020    4,917 Downloads   9,772 Views   Citations


Two new flavones, namely 5,7,2’,5’-tetrahydroxy-3,4’-dimethoxyflavone and 5’-acetoxy-5,7,2’-trihydroxy-3, 4’-dimethoxyflavone were successfuly isolated from the leaves of Acanthospermum hispidum DC and identified by UV-Vis, IR, 1H-NMR and EI-MS techniques. Both compounds exhibited antibacterial activity against Salmonella typii, Staphylococcus aureus, Klebsiella pneumoniae, Proteus mirabilis, Bacillus subtilis, Pseudomonas aeruginosa and Shigella dysenteriae with minimum inhibition concentration (MIC) ranging from 0.001 - 0.20 but was inactive against Escherichia coli, Corybacterium pyogenes and Proteus vulgaris.

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T. Edewor and A. Olajire, "Two Flavones from Acanthospermum hispidum DC and Their Antibacterial Activity," International Journal of Organic Chemistry, Vol. 1 No. 3, 2011, pp. 132-141. doi: 10.4236/ijoc.2011.13020.


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