Association of CALCA Genetic Polymorphism with Essential Hypertension

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Calcitonin gene-related peptide (CGRP) is the predominant neurotransmitter in capsaicin-sensitive sensory nerves. Participation of CGRP in hypertension is one of the most extensively studied topics in the field. There is growing evi-dence to the effect that CGRP is associated with essential hypertension (EH). The aims of this study were to pinpoint whether single nucleotide polymorphisms (SNPs) in the genes coding for CALCA were associated with EH susceptibil-ity in a Hunan Han population. A total of 293 subjects with EH and 208 controls were enrolled in the study. Genomic DNA was extracted from peripheral blood leucocytes by a phenol-chloroform method. The CALCA T-692C was geno-typed using a restriction fragment length polymorphism method. CALCA genetic polymorphism is associated with EH susceptibility. Carriers of at least one C allele at the polymorphic site CALCA T-692C showed increased risk for EH.

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"Association of CALCA Genetic Polymorphism with Essential Hypertension," Chinese Medicine, Vol. 1 No. 1, 2009, pp. 36-41.

Conflicts of Interest

The authors declare no conflicts of interest.

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