Migraine History and Breast Cancer Risk: A Systematic Review and Meta-Analysis

Shahab Rezaeian¹, Yousef Veisani^2*, Mohammad Ghorbani³, Ali Delpisheh⁴, Hedayat Abbastabar³

¹Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
²Student Research Committee, Ilam University of Medical Sciences, Ilam, Iran.
³Department of Epidemiology, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran.
⁴Department of Clinical Epidemiology, Ilam University of Medical Sciences, Ilam, Iran.

DOI: 10.4236/abcr.2015.43007                

Abstract

Objective: The relationship between migraine and breast cancer risk has been reported inconsistently across different epidemiological studies. This meta-analysis was performed to explore the overall effect of migraine on breast cancer risk. Method: An electronic search of different major databases was conducted, including PubMed, Scopus, ScienceDirect, and the Cochrane library until February 1^st, 2015. Of 652 retrieved studies, six population-based studies including two cohort studies with 130,812 and four case-control studies with 14,396 people were included in the analysis. Results: There was an inverse relationship between migraine and breast cancer risk (OR = 0.77; 95% CI: 0.64, 0.92). Conclusion: The results of this meta-analysis showed that women with migraine history have a decreased risk of breast cancer. Further biological studies are needed to address the association.

Keywords

Migraine, Breast cancer, Meta-Analysis

Conflicts of Interest

The authors declare no conflicts of interest.

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