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Maternal PAPP-A Levels at 11 - 13 Weeks of Gestation Predict Foetal and Neonatal Growth

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DOI: 10.4236/ojog.2015.56053    3,553 Downloads   4,272 Views   Citations

ABSTRACT

Recent reports suggest that maternal serum levels of pregnancy-associated plasma protein A (PAPP-A) may predict perinatal outcome. PAPP-A is a syncytiotrophoblast derived protease for insulin-like growth factor binding protein (IGFBP4); its protease activity cleaves complexed growth factor binding protein increasing insulin-like growth factor I (IGF-I) bioavailability. The aim of our study was to evaluate the correlation between maternal PAPP-A serum levels and neonatal growth. We analysed 100 full term and preterm (30 - 36 weeks) small for gestational age (SGA) and adequate for gestational age (AGA) babies whose mothers had been tested for serum PAPP-A at 11 - 13 weeks of gestation. We found a significant positive correlation between maternal PAPP-A and neonatal weight, length, and head circumference at birth in both term and preterm infants. Low maternal PAPP-A serum levels (maternal PAPP-A < 0.5) were associated with small for gestational age neonates. A significant positive correlation was also evident between maternal PAPP-A and babies’ growth parameters at 6 months of age. Our results suggest that maternal levels of PAPP-A in early pregnancy affect growth during both foetal and early postnatal life.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Gentile, M. , Schifano, M. , Lunardi, S. , Nanini, C. , Moscuzza, F. , Sergiampietri, C. , Ciantelli, M. , Monacci, F. , Boldrini, A. , Luchi, C. and Ghirri, P. (2015) Maternal PAPP-A Levels at 11 - 13 Weeks of Gestation Predict Foetal and Neonatal Growth. Open Journal of Obstetrics and Gynecology, 5, 365-372. doi: 10.4236/ojog.2015.56053.

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