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The Effective Catalyst (Cobalt Salt/Lewis Acid) for Beckmann Rearrangement of Cycloalkanone Oximes to Lactams under Mild Conditions

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DOI: 10.4236/ijoc.2015.52007    3,214 Downloads   3,946 Views   Citations

ABSTRACT

The Beckmann rearrangement of cyclohexanone oxime was achieved by the combined use of cobalt salt and Lewis acids co-catalysts (each 10 mol%). Various combinations of cobalt salts and Lewis acids gave lactams in a satisfactory yield under mild conditions. This method makes it possible to reduce undesirable byproducts.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Komeda, M. , Ozaki, A. , Hayashi, K. , Sumimoto, M. , Hori, K. , Sugimoto, T. and Yamamoto, H. (2015) The Effective Catalyst (Cobalt Salt/Lewis Acid) for Beckmann Rearrangement of Cycloalkanone Oximes to Lactams under Mild Conditions. International Journal of Organic Chemistry, 5, 57-62. doi: 10.4236/ijoc.2015.52007.

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