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A Facile Synthesis of 2-Amino-5-Cyano-4, 6-Disubstitutedpyrimidines under MWI

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DOI: 10.4236/ijoc.2011.12009    4,739 Downloads   10,622 Views   Citations

ABSTRACT

Microwave Assisted Organic Synthesis (MAOS) is energy efficient and effective tool to speed up the synthesis for drug discovery process. In the present study we report a novel protocol for the rapid, high throughput synthesis of mononuclear 2-amino-5-cyano-4,6-disubstituted pyrimidines, adaptable to parallel synthesis for compound libraries. The overall reaction time in hrs has been reduced to 25 - 50 minutes with improved yields.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

K. Jain, S. Chaudhari, N. More, K. More, S. Wakedkar and M. Kathiravan, "A Facile Synthesis of 2-Amino-5-Cyano-4, 6-Disubstitutedpyrimidines under MWI," International Journal of Organic Chemistry, Vol. 1 No. 2, 2011, pp. 47-52. doi: 10.4236/ijoc.2011.12009.

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