Serum 17β-estradiol and oral dryness feeling in menopause

Farzaneh Agha-Hosseini, Iraj Mirzaii-Dizgah

.

DOI: 10.4236/health.2011.35046                

Abstract

The aim of this study was to compare serum 17β-estradiol of menopausal women with/without Oral Dryness (OD) feeling, and evaluate the re-lationship between serum 17β-estradiol and severity of OD feeling. A case-control study was carried out on 70 selected menopausal women aged 40 - 77 years with or without OD feeling (35 as case, 35 as control) conducted at the Clinic of Oral Medicine, Tehran University of Medical Sciences. Xerostomia inventory (XI) score was used as an index of OD feeling severity. The serum 17β-estradiol concentration was measured by an enzyme immunoassay kit (ELISA). Statistical analysis of Student’s t-test and Spearman correlation coefficient was used. The mean serum concentration of 17β-estradiol was significantly lower in case than control. There was a significant negative correlation between XI score and concentration of 17β-estradiol in menopausal women (r = –0.311, P = 0.004). It seems that there is a negatively slight correlation between OD feeling severity and serum 17β-estradiol in menopausal women.

Keywords

Menopause; Oral Dryness Feeling; 17β-Estradiol; Serum

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	Frutos, R., Rodríguez, S.S., Miralles-Jorda, L. and Machuca, G. (2002) Oral manifestations and dental treatment in menopause. Oral Medicine, 7, 31-35.
[2]	Bruce, D. and Rymer, J. (2009) Symptoms of the menopause. Best Practice & Research Clinical Obstetrics & Gynaecology, 23, 25-32. doi:10.1016/j.bpobgyn.2008.10.002
[3]	Zachariasen, R.D. (1993) Oral manifestations of menopause. Compendium, 14, 1586-1591.
[4]	Nederfors, T. (2000). Xerostomia and hyposalivation. Advances in Dental Research, 14: 48-56. doi:10.1177/08959374000140010701
[5]	Agha-Hosseini, F., Mirzaii-Dizgah, I., Mansourian, A. and Khayamzadeh, M. (2009) Relationship of stimulated saliva 17beta-estradiol and oral dryness feeling in menopause. Maturitas, 62, 197-199. doi:10.1016/j.maturitas.2008.10.016
[6]	Agha-Hosseini, F., Mirzaii-Dizgah, I., Mansourian, A. and Zabihi-Akhtechi, G. (2009) Serum and stimulated whole saliva parathyroid hormone in menopausal women with oral dry feeling. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology & Endodontics, 107, 806-810. doi:10.1016/j.tripleo.2009.01.024
[7]	Narhi, T.O. (1994) Prevalence of subjective feelings of dry mouth in the elderly. Journal of Dental Research, 73, 20-25. doi:10.1177/00220345940730010301
[8]	Ben, A.H., Gottlieb, I., Ish-Shalom S., David, A., Szargel, H. and Laufer, D. (1996) Oral complaints related to menopause. Maturitas, 24,185-189.
[9]	Agha-Hosseini, F., Tirgari, F. and Shaigan, S. (2006) Immunohistochemical analysis of estrogen and progesterone receptor expression in gingival lesions. Iranian Journal of Public Health, 35, 38-41.
[10]	Forabosco, A., Criscuolo, M., Coukos, G., et al., (1992) Efficacy of hormone replacement therapy in postmenopausal women with oral discomfort. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology & Endodontics, 73, 570-574.
[11]	Eliasson, L., Carlén, A., Lainec, M. and Birkhe, D. (2003) Minor gland and whole saliva in menopausal women using a low potency oestrogen (oestriol). Archives of Oral Biology, 48, 511-517. doi:10.1016/S0003-9969(03)00094-3
[12]	Agha-Hosseini, F., Mirzaii-Dizgah, I., Moghaddam, P.P. and Akrad, Z.T. (2007) Stimulated whole salivary flow rate and composition in menopausal women with oral dryness feeling. Oral Diseases, 13, 320-323. doi:10.1111/j.1601-0825.2006.01288.x
[13]	Thomson, W.M. and Williams, S.M. (2000) Further testing of the xerostomia inventory. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology & Endodontic, 89, 46-50. doi:10.1016/S1079-2104(00)80013-X
[14]	Torres, S.R., Peixoto, C.B., Caldas, D.M., et al. (2000) Relationship between salivary flow rates and Candida counts in subjects with xerostomia. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology & Endodontic, 93,149-154. doi:10.1067/moe.2002.119738
[15]	Ship, J.A., Pillemer, S.R. and Baum, B.J. (2002) Xerostomia and the geriatric patient. Journal of the American Geriatrics Society, 50, 535-543. doi:10.1046/j.1532-5415.2002.50123.x
[16]	Asplund, R. and Aberg, H.E. (2005) Oral dryness, nocturia and the menopause. Maturitas, 50, 86-90. doi:10.1016/j.maturitas.2004.04.009
[17]	Leimola-Virtanen, R., Helenius, H. and Laine, M. (1997) Hormone replacement therapy and some salivary antimicrobial factors in post- and perimenopausal women. Maturitas, 27, 145-151. doi:10.1016/S0378-5122(97)00024-8
[18]	Wardrop, R.W., Hailes, J., Burger, H. and Reade, P.C. (1989) Oral discomfort at menopause. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology & Endodontic, 67, 535-540.
[19]	Yalcin, F., Gurgan, S. and Gurgan, T. (2005) The effect of menopause, hormone replacement therapy (HRT), alendronate (ALN), and calcium supplements on saliva. Journal of Contemporary Dental Practice, 6, 10-17.
[20]	Whitaker, S.B., Bouquot, J.E., Alimari, A.E. and Whitaker, T.J.Jr. (1994) Identification and semiquantification of estrogen and progesterone receptors in pyogenic granulomas of pregnancy. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology & Endodontic, 78, 755-760.
[21]	Yih, W.Y., Richardson, L., Kratochvil, F.J., Avera, S.P. and Zieper, M.B. (2000) Expression of estrogen receptors in desquamative gingivitis. Journal of Periodontology, 71, 482-487. doi:10.1902/jop.2000.71.3.482
[22]	Agha-Hosseini, F., Mirzaii-Dizgah, I. and Mirjalili, N. (2010) Relationship of stimulated whole saliva cortisol level with the severity of a feeling of dry mouth in menopausal women. Gerodontology, in press. doi:10.1111/j.1741-2358.2010.00403.x
[23]	Mirzaii-Dizgah, I. and Agha-Hosseini, F. (2010) Stimulated and unstimulated saliva progesterone in menopausal women with oral dryness feeling. Clinical Oral Investigations, in press. doi:10.1007/s00784-010-0449-z