Spontaneous Uterine Perforation Secondary to Leiomyosarcoma Arising in a Uterine Leiomyoma

Abstract

Histogenesis of uterine leiomyosarcoma has been controversial. It is generally believed that uterine leiomyosarcomas arise de novo, rather than from any precursor lesions. We report an unusual case of spontaneous rupture of leiomyosarcoma arising in pre-existing calcified uterine leiomyoma, which has been monitored over the years after menopause. This case also suggests that spontaneous intraperitoneal hemorrhage associated with malignant transformation of uterine leiomyoma, although rare, should be considered in postmenopausal women presenting with rapid growing uterine mass.

Share and Cite:

Takeuchi, K. , Sugimoto, M. , Yoshida, A. , Yamashita, S. , Tsujino, T. and Nishino, R. (2014) Spontaneous Uterine Perforation Secondary to Leiomyosarcoma Arising in a Uterine Leiomyoma. Open Journal of Obstetrics and Gynecology, 4, 186-189. doi: 10.4236/ojog.2014.44031.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1] Hicks, G., McCallum, I.J., Ogah, K., Guirguis, M. and Kasaraneni, R. (2010) Spontaneous Uterine Perforation Secondary to Uterine Leiomyosarcoma Presenting as Acute Abdomen with Haemoperitoneum. Journal of Obstetrics & Gynaecology, 30, 211-212. http://dx.doi.org/10.3109/ 01443610903477523
[2] Farhi, J., Dicker, D. and Ben-Rafael, Z. (1993) Leiomyosarcoma Presenting as Spontaneous Hemoperitoneum. International Journal of Obstetrics & Gynaecology, 40, 249-450.
http://dx.doi.org/10.1016/0020-7292(93)90839-O
[3] Yanai, H., Wani, Y., Notohara, K., Takada, S. and Yoshino, T. (2010) Uterineleiomyosarcoma Arising in Leiomyoma: Clinicopathological Study of Four Cases and Literature Review. Pathology International, 60, 506-509. http://dx.doi.org/10.1111/j.1440-1827.2010.02549.x
[4] Indraccolo, U., Luchetti, G. and Indraccolo, S.R. (2008) Malignant Transformation of Uterine Leiomyomata. European Journal of Gynaecological Oncology, 29, 543-544.
[5] Mittal, K. and Joutovsky, A. (2007) Areas with Benign Morphologic and Immunohistochemical Features Are Associated with Some Uterine Leiomyosarcomas. Gynecologic Oncology, 104, 362-365.
http://dx.doi.org/10.1016/j.ygyno.2006.08.034
[6] Zaloudek, C. and Hendrickson, M.R. (2001) Mesenchymal Tumors of the Uterus. In: Kuman, R.J., Ed., Blaustein’s Pathology of Female Genital Tract. 5th Edition, Springer-Verlag, New York, 561-615.
[7] Major, F.J., Blessing, J.A., Silverberg, S.G., Morrow, C.P., Creasman, W.T., Currie, J.L., Yordan, E. and Brady, M.F. (1993) Prognostic Factors in Early Stage Uterine Sarcoma: A Gynecologic Oncology Group Study. Cancer, 71, 1702-1709. http://dx.doi.org/10.1002/cncr.2820710440

Copyright © 2021 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.