A case of recurrent rhabdomyolysis associated with childhood Sjögren’s syndrome


We report a 9-year-old Japanese girl who presented with muscle weakness and elevated serum levels of muscle-derived enzymes following mycoplasma infection. Rhabdomyolysis or myositis was suggested by magnetic resonance imaging and repeated four times within 4 years. Each episode developed following respiratory infection and spontaneously recovered. The diagnosis of Sjogren’s syndrome was made by decreased salivary secretion, MR sialography, lip biopsy, and positive anti-SSA/Ro antibody. Given the rarity of rhabdomyolysis/myositis, recurrent episode could be induced by infectious disease on the basis of underlying Sjogren’s syndrome. Conclusion: Sjogren’s syndrome should be considered as an underlying disease of recurrent infection-induced rhabdomyolysis/ myositis.

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Morikawa, S. , Kobayashi, I. , Uzuki, Y. , Ueki, M. , Hattori, T. and Aoyagi, H. (2013) A case of recurrent rhabdomyolysis associated with childhood Sjögren’s syndrome. Open Journal of Pediatrics, 3, 276-278. doi: 10.4236/ojped.2013.33049.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Perreault, S., Birca, A., Piper, D., Nadeau, A., Gauvin, F. and Vanasse, M. (2011) Transient creatine phosphokinase elevation in children: A single-center experience. Journal of Pediatrics, 59, 682-685. doi:10.1016/j.jpeds.2011.03.045
[2] Anaya, J.M., Ogawa, N. and Talal, N. (1995) Sjogren’s syndrome in childhood. The Journal of Rheumatology, 22, 1152-1158.
[3] Kobayashi, I., Furuta, H., Tame, A., Kawamura, N., Kojima, K., Endoh, M., Okano, M. and Sakiyama, Y. (1996) Complications of childhood Sj?gren’s syndrome. European Journal of Pediatrics, 155, 890-894. doi:10.1007/BF02282840
[4] Aoki, A., Ono, S., Ueda, A., Hagiwara, E., Tsuji, T., Misumi, M., Ideguchi, H., Takeda, Y. and Ishigatsubo, Y. (2003) Myositis in primary Sj?gren’s syndrome: Clinical and pathological report. Modern Rheumatology, 13, 57-61. doi:10.1007/s101650300008
[5] Kraus, A., Cifuentes, M., Villa, A.R., Jakez, J., Reyes, E. and Alarcón-Segovia, D. (1994) Myositis in primary Sjogren’s syndrome. Report on three cases. The Journal of Rheumatology, 21, 649-653.
[6] Lindvall, B., Bengtsson, A., Ernerudh, J. and Eriksson, P. (2002) Subclinical myositis is common in primary Sjogren’s syndrome and is not related to muscle pain. The Journal of Rheumatology, 29, 717-725.
[7] Vitali, C., Bombardieri, S., Jonsson, R., Moutsopoulos, H.M., Alexander, E.L., Carsons, S.E., Daniels, T.E., Fox, P.C., Fox, R.I., Kassan, S.S., Pillemer, S.R., Talal, N. and Weisman, M.H. (2002) Classification criteria for Sjogren’s syndrome: A revised version of the European criteria proposed by the American-European Consensus Group. Annals of the Rheumatic Diseases, 61, 554-558. doi:10. 1136/ard.61.6.554
[8] Khan, F.Y. (2009) Rhabdomyolysis: A review of the literature. The Netherlands Journal of Medicine, 67, 272-283.
[9] Kobayashi, I., Ono, S., Kawamura, N., Okano, M. and Kobayashi, K. (2001) Elevated serum levels of soluble interleukin 2 receptor in juvenile dermatomyositis. Pediatrics International, 43, 109-111. doi:10.1046/j.1442-200x.2001.01367.x
[10] Berger, R.P. and Wadowsky, R.M. (2000) Rhabdomyolysis associated with infection by mycoplasma pneumonia: A case report. Pediatrics, 5, 433-436. doi:10.1542/peds.105.2.433

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