A case of Bruton’s disease presenting with recurrent pneumonia

Fatih Akin, Saltuk Bugra Boke, Ece Selma Solak, Cengizhan Kılıcaslan, Sukru Arslan

Department of Pediatric Nephrology, Konya Education and Research Hospital, Konya, Turkey.
Department of Pediatrics, Konya Education and Research Hospital, Konya, Turkey.
Department of Pediatrics, Konya Education and Research Hospital, Konya, Turkey;.

DOI: 10.4236/crcm.2013.26091                

Abstract

X-linked agammaglobulinemia also known as Bruton’s disease, is a humoral immunodeficiency disease characterized by recurrent bacterial infections due to low levels or absence of serum immunoglobulins. It has been shown to be caused by mutations in the gene encoding Bruton tyrosine kinase. Although bacterial infections typically begins 6-9 months after birth when maternal IgG is reduced below the protective level, the diagnosis is established before 5 years of age. Here we report a case with Bruton’s disease and recurrent pneumonia that is typical of the late diagnosed disease. This report suggests the importance of evaluating patients with recurrent infections for immunodeficiency diseases.

 

Keywords

X-Linked Agammaglobulinemia; Recurrent Pneumonia; Immunodeficiency

Conflicts of Interest

The authors declare no conflicts of interest.

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