CIMAvax®EGF vaccine therapy for non-small cell lung cancer: A weighted log-rank tests-based evaluation ()
Carmen Viada Gonzalez,
Jean-François Dupuy,
Martha Fors López,
Patricia Lorenzo Luaces,
Gisela González Marinello,
Elia Neninger Vinagera,
Beatriz García Verdecia,
Tania Crombet-Ramos
Clinical Trials Department, Center of Molecular Immunology, Havana, Cuba.
Clinical Trials Department, Center of Molecular Immunology, Havana, Cuba;.
Hermanos Ameijeiras Hospital, Havana, Cuba.
National Coordinator Center of Clinical Trial, Havana, Cuba.
National Institute of Applied Sciences of Rennes, Rennes, France.
DOI: 10.4236/mc.2013.23006
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Abstract
Time-to-event
has become one of the primary endpoints of many clinical trials. Comparing treatments
and therapies using time-to-event (or “survival”) data requires some care, since
survival differences may occur either early or late in the follow-up period, depending
on various factors such as the initial potency or the duration of efficacy of
the drugs. In this work, we investigate the effect of the CIMAvax?EGF
vaccine therapy on the survival of patients with non-small cell lung cancer, using
stratified and unstratified weighted log-rank tests. Weighted log-rank tests are
designed to identify early and late survival differences
between treatments. Using these tests, we conclude that the vaccine is more
efficient than the standard therapy among patients less than 60 years of age.
Share and Cite:
Gonzalez, C. , Dupuy, J. , López, M. , Luaces, P. , Marinello, G. , Vinagera, E. , Verdecia, B. and Crombet-Ramos, T. (2013) CIMAvax
®EGF vaccine therapy for non-small cell lung cancer: A weighted log-rank tests-based evaluation.
Modern Chemotherapy,
2, 51-56. doi:
10.4236/mc.2013.23006.
Conflicts of Interest
The authors declare no conflicts of interest.
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