Effects of a New Human Recombinant MnSOD in the Treatment of Photoaging and Actinic Keratosis

Maria Grazia Ruggiero, Maria Laura Pollio, Antonietta Schiattarella, Antonella Borrelli, Aldo Mancini, Alessandra Pica, Patrizia Forgione

Department of Biology, University of Naples Federico II, Naples, Italy.
National Cancer Institute “G. Pascale”, Naples, Italy.
Unit of Dermatology, “Ascalesi” Hospital, Naples, Italy.

DOI: 10.4236/jct.2013.46A1009                

Abstract

Physiological processes, as aerobic metabolism and inflammatory response, generate reactive oxygen species (ROS) that may induce cellular injury when their amount is increased and antioxidant defense mechanisms are overwhelmed. Also, ROS are generated following UV skin irradiation able to deplete the natural antioxidant defenses in the skin. The increase in exposure to UV may lead to photoaging and precancerous skin lesions (actinic keratosis). New antioxidant strategies in the prevention and therapy of skin lesions are urgently needed. In this study, we evaluated the antioxidant efficacy of a recombinant form of human manganese superoxide dismutase able to inhibit reactive oxygen species production in some patients affected by severe photoaging and actinic keratosis.

Keywords

Photoaging; Actinic Keratosis; MnSOD; Skin Cancer Lesions

Conflicts of Interest

The authors declare no conflicts of interest.

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