Conjugation of the Recombinant Third Domain of Human Alpha-fetoprotein with Doxorubicin Using Poly(amidoamine) Dendrimers and Study of Its Cytotoxic Activity

DOI: 10.4236/eng.2012.410B021   PDF   HTML     2,808 Downloads   3,909 Views   Citations

Abstract

The recombinant third domain of alpha-fetoprotein (AFP3D) is one of the promising vectors for targeted delivery of anticancer drugs to tumor cells. AFP3D-based conjugates with various anti-tumor agents have shown specific anti-tumor activity. The content of anti-tumor drugs in the preparation could be increased by including dendrimers - highly branched nanoparticles - into a targeted delivery system. In this study, we synthesized the AFP3D conjugate with doxorubicin-loaded poly(amidoamine) (PAMAM) dendrimer nanoparticles and investigated its cytotoxic activity. 

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S. Kisil, V. Chernikov, M. Danilevskiy, L. Savvateeva and N. Gorokhovets, "Conjugation of the Recombinant Third Domain of Human Alpha-fetoprotein with Doxorubicin Using Poly(amidoamine) Dendrimers and Study of Its Cytotoxic Activity," Engineering, Vol. 4 No. 10B, 2012, pp. 80-83. doi: 10.4236/eng.2012.410B021.

Conflicts of Interest

The authors declare no conflicts of interest.

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