Antiproliferative Properties of Vinyl Dipeptides: Synthesis and MCF-7 Cell Line Testing

DOI: 10.4236/ojmc.2012.24013   PDF   HTML   XML   3,348 Downloads   6,513 Views   Citations

Abstract

Peptide mimics derived with close structure to peptide have vast utility because they are expected to interfere with biological targets while having superior drug-like properties if compared to peptides. In this work, novel vinyl dipeptides which are different in a double bond between the α-carbon of peptide and C1 of its side chain. Added to that, suitable substituents were selected to harness drug-like properties. The compounds were found to have moderate activities when tested against MCF-7 breast cancer cell line. For instance, the adamantyl analogue 2-(benzoylamino)-3-(2-furyl)-N-(1-adamantyl) propenamide (1c) and the heterocyclic analogue 2-(Benzoylamino)-3-(2-furyl)-N-[2-(5-cyanothia-zol-2-yl)] propenamide (1o) exhibited inhibition potency at 27.4 and 37.8 μM, respectively.

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A. Bayoumi, "Antiproliferative Properties of Vinyl Dipeptides: Synthesis and MCF-7 Cell Line Testing," Open Journal of Medicinal Chemistry, Vol. 2 No. 4, 2012, pp. 105-111. doi: 10.4236/ojmc.2012.24013.

Conflicts of Interest

The authors declare no conflicts of interest.

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