Effective treatment of resistant Escherichia coli infection, with sulphadimidine stabilized in a synthetic Aluminium-Magnesium Silicate

Maduike C. O. Ezeibe, Uchenna M. Chima, Augustine A. Ngene, Obianuju N. Okoroafor, Idika I. Kalu, Mfon E. Esen

Department of Veterinary Medicine, University of Nigeria, Nsukka, Nigeria.
Department of Veterinary Medicine, University of Nigeria, Nsukka, Nigeria;.
Department of Veterinary Parasitology and Entomology, University of Nigeria, Nsukka, Nigeria.

DOI: 10.4236/health.2012.412190                

Abstract

To investigate if Aluminium-Magnesium Silicate (AMS) could make drugs regain effects against resistant pathogens, its effect was tested on sulphadimidine against sulphadimidine-resistant Escherichia coli. Two groups of chicks infected with sulphadimidine-resistant E. coli were treated at sulphadimidine dose rate of 1 g/litre of drinking water, with sulphadimidine and with an AMS-sulphadimidine drug formulation, respectively. Two other groups were similarly treated at sulphadimidine dose rate of 0.75 g/litre, while the fifth group served as control. Mean titres of the bacterium in bile of the chicks were compared. Titres, 119,200 ± 55,800 CFU/mL of the group treated with sulphadimidine at rate of 1 g/ litre and 14,800 ± 1700 CFU/mL of the group treated at rate of 0.75 g/litre, did not vary from 33,200 ± 5200 CFU/mL of the control (P > 0.05) but 295,200 ± 106,400 CFU/ml of the group treated at rate of 1 g/litre, with the AMS-sulpha- dimidine drug was significantly (P < 0.05) higher than that of the control while 5200 ± 1400 CFU/mL of the group treated at dose of 0.75 g/litre, with the AMS-sulphadimidine drug, reduced significantly (P < 0.05).

Keywords

Resistant Pathogens; Escherichia coli; Sulphadimidine; Aluminium-Magnesium Silicate;Nanoparticles

Conflicts of Interest

The authors declare no conflicts of interest.

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