Analytical Expressions for Steady-State Concentrations of Substrate and Product in an Amperometric Biosensor with the Substrate Inhibition—The Adomian Decomposition Method

DOI: 10.4236/ajac.2012.38066   PDF   HTML   XML   3,131 Downloads   5,625 Views   Citations


A mathematical model of an amperometric biosensor with the substrate inhibition for steady-state condition is discussed. The model is based on the system of non-stationary diffusion equation containing a non-linear term related to non-Michaelis–Menten kinetics of the enzymatic reaction. This paper presents the analytical expression of concentrations and current for all values of parameters φ2s φ2s α and β . Here the Adomian decomposition method (ADM) is used to find the analytical expressions for substrate, product concentration and current. A comparison of the analytical approximation and numerical simulation is also presented. A good agreement between theoretical predictions and numerical results is observed.

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A. Anitha, S. Loghambal and L. Rajendran, "Analytical Expressions for Steady-State Concentrations of Substrate and Product in an Amperometric Biosensor with the Substrate Inhibition—The Adomian Decomposition Method," American Journal of Analytical Chemistry, Vol. 3 No. 8, 2012, pp. 495-502. doi: 10.4236/ajac.2012.38066.

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The authors declare no conflicts of interest.


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