Clinical factors influencing the resting and stimulated salivary flow

Shigeo Yamachika, Ken Yamamoto, Yoshiaki Nomura, Hiroyuki Yamada, Ichiro Saito, Yoichi Nakagawa

Department of Clinical Pathophysiology, School of Dental Medicine, Tsurumi University, Yokohama, Japan.
Department of Geriatric Dentistry, School of Dental Medicine, Tsurumi University, Yokohama, Japan.
Department of Oral and Maxillofacial Surgery, School of Dental Medicine, Tsurumi University, Yokohama, Japan.
Department of Oral Medicine and Stomatology, School of Dental Medicine, Tsurumi University, Yokohama, Japan.
Department of Pathology, School of Dental Medicine, Tsurumi University, Yokohama, Japan.
Department of Translational Research, School of Dental Medicine, Tsurumi University, Yokohama, Japan.

DOI: 10.4236/ojst.2012.22019                

Abstract

Objective: The objective of this study was to examine the clinical and immunological factors influ encing sialometry in xerostomia patients. Method: The association between sialometry and other clinical examinations were investigated in a cross-sectional study. A total of 179 dry mouth patients showing hyposalivation who underwent a clinical examination were enrolled in this study. Multiple regression analyses were employed to examine the relative con-tributions of clinical and immunological factors including age, gender, parotid sialography, labial Salivary gland biopsy, anti-Ro/SS-A antibodies, and anti-La/SS-B antibodies to the resting (RSF) or stimulated saliva flow rate (SSF). Results: An increase of the stage of sialography, the grade of a labial biopsy, and the presence of anti-La/SS-B antibody had a significant correlation with a decrease of sialometry. Results of the multiple regression analysis showed that age (standardized coefficient = -0.244), grade of lip biopsy (-0.189), and anti-SS-B antibody (-0.171), were significantly associated with the RSF. The stage of sialography (?0.423) and age (-0.169) were significantly related to the sialometry in the SSF according to a multiple regression analysis. Conclusion: The results of this study suggest that the measurement of RSF reflects the immunological factors and SSF reflects the damage to the parotid gland.

Keywords

Xerostomia; Sialometry; Sialography; Labial Minor Salivary Gland Biopsy; Sjögren’s Syndrome

Conflicts of Interest

The authors declare no conflicts of interest.

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